Patents by Inventor Domenick J. Falcone

Domenick J. Falcone has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Affinity purified heparin
    Patent number: 5807982
    Abstract: The present invention relates to a method for purifying heparin into two subspecies of molecules, one which binds transforming growth factor-.beta. (TGF-.beta.), and another which does not. The method involves using a peptide, immobilized on a chromatography substrate, that is homologous to the heparin-binding region of TGF-.beta. and allowing the heparin to contact the immobilized peptide for a sufficient time to cause binding. The fraction of heparin which does not bind to the peptide retains its activity as an anticoagulant but is devoid of the ability to bind TGF-.beta..
    Type: Grant
    Filed: April 29, 1991
    Date of Patent: September 15, 1998
    Assignee: Cornell Research Foundation, Inc.
    Inventors: Timothy A. McCaffrey, Domenick J. Falcone