Patents by Inventor Domenico G. Barone

Domenico G. Barone has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • HMGB1 high affinity binding domain Box-A mutants
    Patent number: 8058232
    Abstract: The present invention relates to polypeptide variants of the HMGB-1 high affinity binding domain Box-A (HMGB1 Box-A) or to a biologically active fragment of HMGB1 Box-A, which are obtained through systematic mutations of single amino acids of the wild-type HMGB1 Box-A protein and which show an increased resistance to proteases and which are therefore characterized by more favorable pharmacokinetic and pharmacodynamic profiles. Moreover, the present invention concerns the use of said polypeptide molecules of HMGB1 Box-A to diagnose, prevent, alleviate and/or treat pathologies associated with extracellular HMGB1 and associated with RAGE.
    Type: Grant
    Filed: November 9, 2009
    Date of Patent: November 15, 2011
    Assignee: Creabilis Therapeutics S.p.A.
    Inventors: Silvano Fumero, Luisa Bertarione Rava Rossa, Domenico G. Barone, Lila Drittanti, Thierry Guyon, Gilles Borrelly, Barbara Canepa, Chiara Lorenzetto
  • USE OF POLYPEPTIDES OBTAINED THROUGH SYSTEMATIC MUTATIONS OF SINGLE AMINO ACIDS OF HUMAN AND NON-HUMAN BOX-A OF HMGB1 TO PREVENT AND/OR ANTAGONIZE PATHOLOGIES INDUCED BY HMGB1
    Publication number: 20110052493
    Abstract: The present invention relates to polypeptide variants of the HMGB-1 high affinity binding domain Box-A (HMGB1 Box-A) or to a biologically active fragment of HMGB1 Box-A, which are obtained through systematic mutations of single amino acids of the wild-type HMGB1 Box-A protein and which show an increased resistance to proteases and which are therefore characterized by more favourable pharmacokinetic and pharmacodynamic profiles. Moreover, the present invention concerns the use of said polypeptide molecules of HMGB1 Box-A to diagnose, prevent, alleviate and/or treat pathologies associated with extracellular HMGB1 and associated with RAGE.
    Type: Application
    Filed: November 9, 2009
    Publication date: March 3, 2011
    Applicant: CREABILIS THERAPEUTICS S.P.A.
    Inventors: Silvano FUMERO, Luisa Bertarione Rava Rossa, Domenico G. Barone, Lila Drittanti, Thierry Guyon, Gilles Borrelly, Barbara Canepa, Chiara Lorenzetto
  • Protease resistant mutant of human HMGB1 high affinity binding domain Box-A (HMGB1 Box-A)
    Patent number: 7635679
    Abstract: The present invention relates to polypeptide variants of the HMGB-1 high affinity binding domain Box-A (HMGB1 Box-A) or to a biologically active fragment of HMGB1 Box-A, which are obtained through systematic mutations of single amino acids of the wild-type HMGB1 Box-A protein and which show an increased resistance to proteases and which are therefore characterized by more favorable pharmacokinetic and pharmacodynamic profiles. Moreover, the present invention concerns the use of said polypeptide molecules of HMGB1 Box-A to diagnose, prevent, alleviate and/or treat pathologies associated with extracellular HMGB1 and associated with RAGE.
    Type: Grant
    Filed: March 5, 2007
    Date of Patent: December 22, 2009
    Assignee: Creabilis Therapeutics S.p.A.
    Inventors: Silvano Fumero, Luisa Bertarione Rava Rossa, Domenico G. Barone, Lila Drittanti, Thierry Guyon, Gilles Borrelly, Barbara Canepa, Chiara Lorenzetto
  • Therapeutic Agents for the Treatment of Hmgb1-Related Pathologies
    Publication number: 20080305073
    Abstract: The present invention relates to the use of synthetic double-stranded nucleic acid or nucleic acid analogue molecules with a bent shape structure for the prevention and treatment of pathologies induced directly or indirectly by the HMGB1 protein.
    Type: Application
    Filed: July 4, 2005
    Publication date: December 11, 2008
    Inventors: Domenico G. Barone, Marco E. Bianchi, Enrico M. Bucci, Silvano Fumero, Margherita Valente, Roberto Sapio, Domenica Musumeci