Patents by Inventor Domenico Maglione

Domenico Maglione has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Production process of recombinant placental growth factor
    Patent number: 7744862
    Abstract: Process for extracting and purifying the recombinant Placental Growth Factor (PLGF) expressed in inducible prokaryotic expression systems comprising the following steps: I) fermentation of the bacterial cells, II) extraction and purification of the inclusion bodies, III) renaturation of the expressed protein, IV) ion-exchange chromatography, V) reverse-phase chromatography.
    Type: Grant
    Filed: February 5, 2002
    Date of Patent: June 29, 2010
    Assignee: Geymonat S.p.A.
    Inventors: Domenico Maglione, Mauro Battisti, Ettore Conti, Giuseppe Salvia, Marina Tucci
  • Pharmaceutical and cosmetic compositions comprising plgf-1
    Patent number: 7364722
    Abstract: The invention relates to the preparation of placental growth factor (PLGF)-comprising therapeutic and cosmetic compositions capable of increasing angiogenesis of the cutaneous, subcutaneous and internal organ connective tissue. Such compositions are suitable for the treatment of pathological or natural states benefiting from the formation or regeneration of new vessels of the cutaneous compartment, such as scleroderma, its various manifestations, skin aging or loss of hair.
    Type: Grant
    Filed: March 5, 2003
    Date of Patent: April 29, 2008
    Assignee: Geymonat S.p.A.
    Inventors: Domenico Maglione, Mauro Battisti, Ettore Conti, Giuseppe Salvia, Marina Tucci
  • Muteins of placental growth factor type 1, preparation method and application thereof
    Patent number: 7314734
    Abstract: The present invention relates to chemically stable muteins of type 1 Placental Growth Factor (PLGF-1) bearing the substitution or elimination of a cysteine residue from the wild type protein amino acid sequence, their preparation, their therapeutic and cosmetic uses, and pharmaceutical and cosmetic compositions containing said derivatives. The invention likewise relates to the production of antibodies for said derivatives and their use in the diagnosis and treatment of tumoral and non-tumoral pathologies.
    Type: Grant
    Filed: May 19, 2003
    Date of Patent: January 1, 2008
    Inventors: Domenico Maglione, Mauro Battisti, Ettore Conti, Giuseppe Salvia, Marina Tucci, Alberto Mion
  • Pharmaceutical and Cosmetic Compositions Comprising PLGF-1
    Publication number: 20050239698
    Abstract: Abstract of the Disclosure The invention relates to the preparation of placental growth factor (PLGF)-comprising therapeutic and cosmetic compositions capable of increasing angiogenesis of the cutaneous, subcutaneous and internal organ connective tissue. Such compositions are suitable for the treatment of pathological or natural states benefiting from the formation or regeneration of new vessels of the cutaneous compartment, such as seleroderma, its various manifestations, skin ageing or loss of hair.
    Type: Application
    Filed: November 22, 2004
    Publication date: October 27, 2005
    Applicant: Geymonat S.p.A.
    Inventors: Domenico Maglione, Mauro Battisti, Ettore Conti, Giuseppe Salvia, Marina Tucci
  • Muteins of placental growth factor type 1, preparation method and application thereof
    Publication number: 20050176634
    Abstract: The present invention relates to chemically stable muteins of type 1 Placental Growth Factor (PLGF-1) bearing the substitution or elimination of a cysteine residue from the wild type protein amino acid sequence, their preparation, their therapeutic and cosmetic uses, and pharmaceutical and cosmetic compositions containing said derivatives. The invention likewise relates to the production of antibodies for said derivatives and their use in the diagnosis and treatment of tumoral and non-tumoral pathologies.
    Type: Application
    Filed: May 19, 2003
    Publication date: August 11, 2005
    Applicant: GEYMONAT S.p.A.
    Inventors: Domenico Maglione, Mauro Battisti, Ettore Conti, Giuseppe Salvia, Marina Tucci, Alberto Mion
  • Pharmaceutical and cosmetic compositions comprising plgf-1
    Publication number: 20050075288
    Abstract: The invention relates to the preparation of placental growth factor (PLGF)-comprising therapeutic and cosmetic compositions capable of increasing angiogenesis of the cutaneous, subcutaneous and internal organ connective tissue. Such compositions are suitable for the treatment of pathological or natural states benefiting from the formation or regeneration of new vessels of the cutaneous compartment, such as seleroderma, its various manifestations, skin ageing or loss of hair.
    Type: Application
    Filed: March 5, 2003
    Publication date: April 7, 2005
    Inventors: Domenico Maglione, Mauro Battisti, Ettore Conti
  • Production process of recombinant placental growth factor
    Publication number: 20050070696
    Abstract: Process for extracting and purifying the recombinant Placental Growth Factor (PLGF) expressed in inducible prokaryotic expression systems comprising the following steps: I) fermentation of the bacterial cells, II) extraction and purification of the inclusion bodies, III) renaturation of the expressed protein, IV) ion-exchange chromatography, V) reverse-phase chromatography.
    Type: Application
    Filed: February 5, 2002
    Publication date: March 31, 2005
    Inventors: Domenico Maglione, Mauro Battisti, Ettore Conti, Giuseppe Salvia, Marina Tucci
  • Human protein with angiogenesis regulative properties
    Patent number: 5919899
    Abstract: Disclosed are an isolated and purified protein acting as an angiogenic factor and nucleotide sequences encoding for such a protein, vectors containing such sequences and cells transformed by such vectors.
    Type: Grant
    Filed: April 19, 1993
    Date of Patent: July 6, 1999
    Assignee: Consiglio Nazionale Delle Ricerche
    Inventors: Maria Persico, Domenico Maglione