Patents by Inventor Domenico Magrone

Domenico Magrone has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Chemical process for opening ring compounds
    Patent number: 9067868
    Abstract: It is described a process for the opening of lactone or lactam rings useful in the synthesis of pharmaceutically active compounds and the intermediates thereof, particularly Aliskiren. It has found that by selecting a type of solvent it is possible to obtain excellent yields and high optical and chemical purity of the isolated products.
    Type: Grant
    Filed: July 25, 2012
    Date of Patent: June 30, 2015
    Assignee: Chemo Iberica, S.A.
    Inventors: Luca Carcone, Domenico Magrone, Giuseppe Barreca, Marcello Rasparini, Huang Liming
  • Polymorphic forms of asenapine maleate and processes for their preparation
    Patent number: 8933114
    Abstract: Are disclosed new crystalline forms of asenapine maleate, useful in the production of pharmaceutical formulations for the treatment of diseases of the central nervous system, in particular schizophrenia; processes for the production of these new crystalline forms are also disclosed.
    Type: Grant
    Filed: December 12, 2011
    Date of Patent: January 13, 2015
    Assignee: Chemo Iberica, S.A.
    Inventors: Gianpiero Ventimiglia, Giuseppe Barreca, Domenico Magrone
  • CHEMICAL PROCESS FOR OPENING RING COMPOUNDS
    Publication number: 20140213821
    Abstract: It is described a process for the opening of lactone or lactam rings useful in the synthesis of pharmaceutically active compounds and the intermediates thereof, particularly Aliskiren. It has found that by selecting a type of solvent it is possible to obtain excellent yields and high optical and chemical purity of the isolated products.
    Type: Application
    Filed: July 25, 2012
    Publication date: July 31, 2014
    Applicant: CHEMO IBERICA, S. A.
    Inventors: Luca Carcone, Domenico Magrone, Giuseppe Barreca, Marcello Rasparini, Huang Liming
  • Polymorphic Forms of Asenapine Maleate and Processes for their Preparation
    Publication number: 20130267574
    Abstract: Are disclosed new crystalline forms of asenapine maleate, useful in the production of pharmaceutical formulations for the treatment of diseases of the central nervous system, in particular schizophrenia; processes for the production of these new crystalline forms are also disclosed.
    Type: Application
    Filed: December 12, 2011
    Publication date: October 10, 2013
    Inventors: Gianpiero Ventimiglia, Giuseppe Barreca, Domenico Magrone
  • ZIPRASIDONE FREE FROM COLORED IMPURITIES AND A PROCESS FOR ITS PREPARATION
    Publication number: 20090312550
    Abstract: Ziprasidone base or a pharmaceutically acceptable salt thereof free from colored impurities, in particular those giving the product a “slightly pink to pink” coloration.
    Type: Application
    Filed: June 17, 2009
    Publication date: December 17, 2009
    Applicant: DIPHARMA FRANCIS SRL
    Inventors: Gianpiero Ventimiglia, Pietro Allegrini, Gabriele Razzetti, Domenico Magrone, Alberto Bologna
  • Ziprasidone free from colored impurities and a process for its preparation
    Patent number: 7563794
    Abstract: Ziprasidone base or a pharmaceutically acceptable salt thereof free from colored impurities, in particular those giving the product a “slightly pink to pink” coloration.
    Type: Grant
    Filed: March 7, 2006
    Date of Patent: July 21, 2009
    Assignee: Dipharma Francis S.r.l.
    Inventors: Gianpiero Ventimiglia, Pietro Allegrini, Gabriele Razzetti, Domenico Magrone, Alberto Bologna
  • PHENYLTETRAZOLE COMPOUNDS
    Publication number: 20080119657
    Abstract: Novel phenyltetrazole compounds useful as intermediates in the preparation of angiotensin II antagonists and the processes for the conversion thereof to biologically active molecules.
    Type: Application
    Filed: January 29, 2008
    Publication date: May 22, 2008
    Applicant: DIPHARMA S. P. A.
    Inventors: Gabriele RAZZETTI, Domenico Magrone, Mauro Ercoli
  • Phenyltetrazole compounds
    Patent number: 7345072
    Abstract: Novel phenyltetrazole compounds useful as intermediates in the preparation of angiotensin II antagonists and the processes for the conversion thereof to biologically active molecules.
    Type: Grant
    Filed: November 24, 2004
    Date of Patent: March 18, 2008
    Assignee: Dipharma S.p.A.
    Inventors: Gabriele Razzetti, Domenico Magrone, Mauro Ercoli
  • Protriptyline hydrochloride crystalline form
    Publication number: 20070112073
    Abstract: Protriptyline hydrochloride crystalline Form B, a process for its preparation, a pharmaceutical composition containing it the use thereof.
    Type: Application
    Filed: November 14, 2006
    Publication date: May 17, 2007
    Applicant: DIPHARMA S.p.A.
    Inventors: Gianpiero Ventimiglia, Domenico Magrone, Pietro Allegrini, Gabriele Razzetti
  • Process for the purification of imiquimod
    Publication number: 20070010675
    Abstract: Crystalline forms of imiquimod, a process for the preparation thereof and the use thereof in the purification of imiquimod.
    Type: Application
    Filed: July 7, 2006
    Publication date: January 11, 2007
    Applicant: DIPHARMA S.p.A.
    Inventors: Pietro Allegrini, Gabriele Razzetti, Alberto Bologna, Domenico Magrone, Gianpiero Ventimiglia
  • Ziprasidone free from colored impurities and a process for its preparation
    Publication number: 20060211708
    Abstract: Ziprasidone base or a pharmaceutically acceptable salt thereof free from colored impurities, in particular those giving the product a “slightly pink to pink” coloration.
    Type: Application
    Filed: March 7, 2006
    Publication date: September 21, 2006
    Inventors: Gianpiero Ventimiglia, Pietro Allegrini, Gabriele Razzetti, Domenico Magrone, Alberto Bologna
  • Process for the preparation of crystalline losartan potassium
    Publication number: 20050131040
    Abstract: A process for the preparation of crystalline losartan potassium and crystalline hydrate losartan potassium.
    Type: Application
    Filed: December 14, 2004
    Publication date: June 16, 2005
    Applicant: DIPHARMA S.P.A.
    Inventors: Gabriele Razzetti, Domenico Magrone, Mauro Ercoli, Pietro Allegrini, Graziano Castaldi
  • Phenyltetrazole compounds
    Publication number: 20050119488
    Abstract: Novel phenyltetrazole compounds useful as intermediates in the preparation of angiotensin II antagonists and the processes for the conversion thereof to biologically active molecules.
    Type: Application
    Filed: November 24, 2004
    Publication date: June 2, 2005
    Applicant: DIPHARMA S.P.A.
    Inventors: Gabriele Razzetti, Domenico Magrone, Mauro Ercoli
  • Process for the preparation of 4-[1-hydroxy -4-[4-(hydroxydiphenylmethly)-1-piperidinyl]-butyl]-&agr;, &agr;-dimethylbenzeneacetic acid
    Patent number: 6815549
    Abstract: A process for the preparation of 4-[1-hydroxy-4-[4-(hydroxydiphenylmethyl)-1-piperidinyl]-butyl]-&agr;,&agr;-dimethylbenzeneacetic acid (Fexofenadine) of formula
    Type: Grant
    Filed: May 16, 2002
    Date of Patent: November 9, 2004
    Assignee: Dinamite Dipharma S.p.A.
    Inventors: Graziano Castaldi, Giuseppe Barreca, Domenico Magrone
  • Clopidogrel salts with alkyl-sulphuric acids
    Publication number: 20040132765
    Abstract: Clopidogrel salts with alkyl-sulphuric acids, having the following formula (I) 1
    Type: Application
    Filed: October 17, 2003
    Publication date: July 8, 2004
    Applicants: DINAMITE DIPHARMA S.P.A., ABBREVIATED DIPHARMA S.P.A.
    Inventors: Graziano Castaldi, Alberto Bologna, Domenico Magrone
  • Process for the preparation of 4-[1-hydroxy-4-[4-(hydroxydiphenylmethly)-1-piperidinyl]-butyl]-alpha,alpha-dimethylbenzeneacetic acid
    Publication number: 20020198233
    Abstract: A process for the preparation of 4-[1-hydroxy-4-[4-(hydroxydiphenylmethyl)-1-piperidinyl]-butyl]-&agr;,&agr;-dimethylbenzeneacetic acid (Fexofenadine) of formula 1
    Type: Application
    Filed: May 16, 2002
    Publication date: December 26, 2002
    Inventors: Graziano Castaldi, Giuseppe Barreca, Domenico Magrone
  • Process for the purification of (RR,SS)-2-(dimethylamino) methyl-1-(3-methoxyphenyl)-cyclohexanol from (RS,SR)-2-(dimethylamino)methyl-1-(3-methoxyphenyl) cyclohexanol
    Patent number: 6169205
    Abstract: A process for the purification of (RR,SS)-2-(dimethylamino)methyl-1-(3-methoxyphenyl)cyclohexanol, which comprises the selective precipitation of (RR,SS)-2-(dimethylamino)methyl-1-(3-methoxyphenyl)cyclohexanol in the presence of (RS,SR)-2-(dimethylamino)methyl-1-(3-methoxyphenyl)cyclohexanol from a solvent consisting of water and a water-miscible organic solvent.
    Type: Grant
    Filed: March 4, 1999
    Date of Patent: January 2, 2001
    Assignee: Dipharma S.p.A.
    Inventors: Walter Cabri, Domenico Magrone
  • Process for the preparation of 4-(6'-methoxy-2'-naphthyl) butan-2-one
    Patent number: 5955635
    Abstract: An improved process for the preparation of Nabumetone, which comprises the following steps:a) condensation between 6-methoxy-naphthaldehyde I and t-butyl acetoacetate II, to give 3-t-butoxycarbonyl-4-(6'-methoxy-2'-naphthyl)-but-3-en-2-one III as an E/Z mixture;b) hydrogenation of III in the presence of a palladium catalyst, to give 3-t-butoxycarbonyl-4-(6'-methoxy-2-naphthyl)-butan-2-one IV;c) cleavage of the t-butyl ester by acid catalysis; andd) recrystallization of the crude with methanol.
    Type: Grant
    Filed: April 24, 1998
    Date of Patent: September 21, 1999
    Assignee: Secifarma S.P.A.
    Inventors: Walter Cabri, Domenico Magrone, Roberto Angelini, Erminio Oldani