Patents by Inventor Domenico Mastroianni

Domenico Mastroianni has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • FGF2-binding peptides and uses thereof
    Patent number: 8076300
    Abstract: FGF2-binding peptides are here described, which have been designed starting from the N-terminal region of PTX3, in particular spanning the PTX3(82-11O) region. Synthetic peptides related to this sequence are able to bind FGF2 and to inhibit its pro-angiogenic activity in vitro and in vivo with no anticipated impact on innate immunity.
    Type: Grant
    Filed: January 23, 2007
    Date of Patent: December 13, 2011
    Assignee: Tecnogen S.p.A.
    Inventors: Marco Presta, Maura Camozzi, Marco Rusnati, Maurizio Colombo, Domenico Mastroianni
  • FGF2-BINDING PEPTIDES AND USES THEREOF
    Publication number: 20090215689
    Abstract: FGF2-binding peptides are here described, which have been designed starting from the N-terminal region of PTX3, in particular spanning the PTX3(82-110) region. Synthetic peptides related to this sequence are able to bind FGF2 and to inhibit its pro-angiogenic activity in vitro and in vivo with no anticipated impact on innate immunity.
    Type: Application
    Filed: January 23, 2007
    Publication date: August 27, 2009
    Inventors: Marco Presta, Maura Camozzi, Marco Rusnati, Maurizio Colombo, Domenico Mastroianni
  • Myd88 Homodimerization Inhibitors
    Publication number: 20080064643
    Abstract: The present invention relates to peptidic and peptidomimetic compounds with the formula (X?)AA1-AA2-AA3-AA4-AA5-AA6-AA7 in which the various groups are defined in the description here below, which mimic a particular protein portion of MyD88, preventing its homodimerisation and interfering with its interaction with the TIR domain. The present invention also provides procedures for the preparation of said compounds, pharmaceutical compositions containing them and their use as medicaments, particularly for the treatment of inflammatory and autoimmune diseases.
    Type: Application
    Filed: December 16, 2005
    Publication date: March 13, 2008
    Inventors: Paolo Carminati, Grazia Gallo, Nicola Fanto, Vito Ruggiero, Marica Sassano, Domenico Mastroianni
  • Pyrrolo[2,1-B][3,1] benzothiazepines and their use for the preparation of medicaments with antipsychotic activity
    Patent number: 6710041
    Abstract: A compound of formula (I): where: R=H, Cl, Br, F, I, C1-C4 alkoxy, C1-C4 alkylthio, C1-C4 alkyl, or C5-C6 cycloalkyl; R1 =C1-C4 dialkylamine, where the alkyl groups are the same or different from one another, 4-alkyl-1-piperazinyl, 4-hydroxyalkyl-1-piperazinyl, 1-imidazolyl, 4-alkyl-1-piperidinyl, or 4-alkyl-1-homopiperazinyl; R2 =H, C1-C4 alkoxy, C1-C4 alkylthio, C1-C4 alkyl, CHO, or CH=NOH; R3 =H, CHO; or the pharmaceutically acceptable salts thereof.
    Type: Grant
    Filed: February 3, 2003
    Date of Patent: March 23, 2004
    Assignee: Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.
    Inventors: Patrizia Minetti, Assunta Di Cesare, Domenico Mastroianni, Giuseppe Campiani, Vito Nacci
  • Pyrrolo[2,1-b][3,1] benzothiazepines and their use for the preparation of medicaments with antipsychotic activity
    Publication number: 20030186959
    Abstract: Compounds with formula (I) are described where the groups are as defined here below, as well as processes for their preparation, pharmaceutical compositions containing them and their use for the preparation of medicaments with antipsychotic activity.
    Type: Application
    Filed: February 3, 2003
    Publication date: October 2, 2003
    Inventors: Patrizia Minetti, Assunta Di Cesare, Domenico Mastroianni, Giuseppe Campiani, Vito Nacci