Abstract: A device and system for non-invasively measuring wavelength-dependent changes in optical absorption of brain tissue damaged by CTE, TBI, concussion, repetitive trauma, and/or Lou Gehrig’s disease in comparison to signals from healthy normal tissue for a subject in vivo. The brain, tissues, and fluids superficial to the brain are trans-cranially illuminated by light source(s) in low-absorption spectral windows for tissue in the visible and/or near-infrared parts of the spectrum. Optode(s) are disposed at predetermined radial distance(s) from a light output to collect the scattered and/or deflected signal from the surface of the head. The predetermined radial distance from the light output to the optode is correlated with the depth of tissue penetration for the light collected by the optode. A spectrometer and computer analyze the collected light for characteristic optical signatures of the brain tissue damage utilizing the absorbance and/or reflectance and/or transmission spectra generated as a result.

Abstract: A device and system for non-invasively measuring wavelength-dependent changes in optical absorption of brain tissue damaged by CTE, TBI, concussion, repetitive trauma, and/or Lou Gehrig's disease in comparison to signals from healthy normal tissue for a subject in vivo. The brain, tissues, and fluids superficial to the brain are trans-cranially illuminated by light source(s) in low-absorption spectral windows for tissue in the visible and/or near-infrared parts of the spectrum. Optode(s) are disposed at predetermined radial distance(s) from a light output to collect the scattered and/or deflected signal from the surface of the head. The predetermined radial distance from the light output to the optode is correlated with the depth of tissue penetration for the light collected by the optode. A spectrometer and computer analyze the collected light for characteristic optical signatures of the brain tissue damage utilizing the absorbance and/or reflectance and/or transmission spectra generated as a result.

Abstract: A device and system for non-invasively measuring wavelength-dependent changes in optical absorption of brain tissue damaged by CTE, TBI, concussion, repetitive trauma, and/or Lou Gehrig's disease in comparison to signals from healthy normal tissue for a subject in vivo. The brain, tissues, and fluids superficial to the brain are trans-cranially illuminated by light source(s) in low-absorption spectral windows for tissue in the visible and/or near-infrared parts of the spectrum. Optode(s) are disposed at predetermined radial distance(s) from a light output to collect the scattered and/or deflected signal from the surface of the head. The predetermined radial distance from the light output to the optode is correlated with the depth of tissue penetration for the light collected by the optode. A spectrometer and computer analyze the collected light for characteristic optical signatures of the brain tissue damage utilizing the absorbance and/or reflectance and/or transmission spectra generated as a result.

Abstract: A system and method for sensing an optical input having a wide dynamic range includes providing a semiconductor material extending along a reference axis away from an optical input surface and having more than one substantially planar photodetecting regions disposed therein at different respective depths. The substantially planar photodetecting regions are configured to be overlapping and at least partially transverse to the reference axis, such that more than one of the regions absorb the optical input received through the optical input surface. Each of the photodetecting regions has an associated responsivity representative of the absorption of the incident optical signal. Preferably, the responsivity of each of the photodetecting regions is different for each of the photodetecting regions. A wide dynamic range sensor signal is produced by combining electrical output signals obtained from each of the more than one photodetecting regions.

Abstract: A system and method for sensing an optical input having a wide dynamic range includes providing a semiconductor material extending along a reference axis away from an optical input surface and having more than one substantially planar photodetecting regions disposed therein at different respective depths. The substantially planar photodetecting regions are configured to be overlapping and at least partially transverse to the reference axis, such that more than one of the regions absorb the optical input received through the optical input surface. Each of the photodetecting regions has an associated responsivity representative of the absorption of the incident optical signal. Preferably, the responsivity of each of the photodetecting regions is different for each of the photodetecting regions. A wide dynamic range sensor signal is produced by combining electrical output signals obtained from each of the more than one photodetecting regions.

Abstract: A system and method for sensing an optical input having a wide dynamic range includes providing a semiconductor material extending along a reference axis away from an optical input surface and having more than one substantially planar photodetecting regions disposed therein at different respective depths. The substantially planar photodetecting regions are configured to be overlapping and at least partially transverse to the reference axis, such that more than one of the regions absorb the optical input received through the optical input surface. Each of the photodetecting regions has an associated responsivity representative of the absorption of the incident optical signal. Preferably, the responsivity of each of the photodetecting regions is different for each of the photodetecting regions. A wide dynamic range sensor signal is produced by combining electrical output signals obtained from each of the more than one photodetecting regions.