Patents by Inventor Domingos Ng

Domingos Ng has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PRODUCTION OF HETEROMULTIMERIC PROTEINS USING MAMMALIAN CELLS
    Publication number: 20220002386
    Abstract: Described herein are methods for the efficient production of antibodies and other multimeric protein complexes (collectively referred to herein as heteromultimeric proteins) capable of specifically binding to more than one target. The targets may be, for example, different epitopes located on a single molecule or located on different molecules.
    Type: Application
    Filed: February 9, 2021
    Publication date: January 6, 2022
    Applicant: Genentech, Inc.
    Inventors: Justin SCHEER, Whitney SHATZ, Domingos NG
  • Decreasing lactate level and increasing polypeptide production by downregulating the expression of lactate dehydrogenase and pyruvate dehydrogenase kinase
    Patent number: 11046987
    Abstract: The present invention provides methods and compositions for reducing lactate production and increasing polypeptide production in cultured cells. In one aspect, the invention provides a method comprising culturing cells expressing a) a small interfering RNA (siRNA) specific for a lactate dehydrogenase (LDH) and b) an siRNA specific for a pyruvate dehydrogenase kinase (PDHK). In another aspect, the invention provides cultured cells or vectors comprising an siRNA specific for a LDH and an siRNA specific for a PDHK.
    Type: Grant
    Filed: May 29, 2020
    Date of Patent: June 29, 2021
    Assignee: Genentech, Inc.
    Inventors: Meixia Zhou, Bradley Richard Snedecor, Chi Kin Domingos Ng, Amy Shen
  • Production of heteromultimeric proteins using mammalian cells
    Patent number: 10941190
    Abstract: Described herein are methods for the efficient production of antibodies and other multimeric protein complexes (collectively referred to herein as heteromultimeric proteins) capable of specifically binding to more than one target. The targets may be, for example, different epitopes located on a single molecule or located on different molecules.
    Type: Grant
    Filed: November 4, 2016
    Date of Patent: March 9, 2021
    Assignee: Genentech, Inc.
    Inventors: Justin Scheer, Whitney Shatz, Domingos Ng
  • TARGETED INTEGRATION OF NUCLEIC ACIDS
    Publication number: 20210002669
    Abstract: The presently disclosed subject matter relates to targeted integration (TI) host cells suitable for the expression of recombinant proteins, as well as methods of producing and using said TI host cells.
    Type: Application
    Filed: December 21, 2018
    Publication date: January 7, 2021
    Applicant: GENENTECH, INC.
    Inventors: Chi Kin Domingos Ng, Yongping Guo Crawford, Amy Shen, Meixia Zhou, Bradley R. Snedecor, Shahram Misaghi, Albert Eric Gao
  • DECREASING LACTATE LEVEL AND INCREASING POLYPEPTIDE PRODUCTION BY DOWNREGULATING THE EXPRESSION OF LACTATE DEHYDROGENASE AND PYRUVATE DEHYDROGENASE KINASE
    Publication number: 20200377919
    Abstract: The present invention provides ethods and compositions for reducing lactate production and increasing polypeptide production in cultured cells. In one aspect, the invention provides a method comprising culturing cells expressing a) a small interfering RNA (siRNA) specific for a lactate dehydrogenase (LDH) and b) an siRNA specific for a pyruvate dehydrogenase kinase (PDHK). In another aspect, the invention provides cultured cells or vectors comprising an siRNA specific for a LDH and an siRNA specific for a PDHK.
    Type: Application
    Filed: May 29, 2020
    Publication date: December 3, 2020
    Applicant: Genentech, Inc.
    Inventors: Meixia ZHOU, Bradley Richard SNEDECOR, Chi Kin Domingos NG, Amy SHEN
  • Decreasing lactate level and increasing polypeptide production by down regulating the expression of lactate dehydrogenase and pyruvate dehydrogenase kinase
    Patent number: 10704071
    Abstract: The present invention provides methods and compositions for reducing lactate production and increasing polypeptide production in cultured cells. In one aspect, the invention provides a method comprising culturing cells expressing a) a small interfering RNA (siRNA) specific for a lactate dehydrogenase (LDH) and b) an siRNA specific for a pyruvate dehydrogenase kinase (PDHK). In another aspect, the invention provides cultured cells or vectors comprising an siRNA specific for a LDH and an siRNA specific for a PDHK.
    Type: Grant
    Filed: May 31, 2018
    Date of Patent: July 7, 2020
    Assignee: Genentech, Inc.
    Inventors: Meixia Zhou, Bradley Richard Snedecor, Chi Kin Domingos Ng, Amy Shen
  • DECREASING LACTATE LEVEL AND INCREASING POLYPEPTIDE PRODUCTION BY DOWNREGULATING THE EXPRESSION OF LACTATE DEHYDROGENASE AND PYRUVATE DEHYDROGENASE KINASE
    Publication number: 20190040435
    Abstract: The present invention provides methods and compositions for reducing lactate production and increasing polypeptide production in cultured cells. In one aspect, the invention provides a method comprising culturing cells expressing a) a small interfering RNA (siRNA) specific for a lactate dehydrogenase (LDH) and b) an siRNA specific for a pyruvate dehydrogenase kinase (PDHK). In another aspect, the invention provides cultured cells or vectors comprising an siRNA specific for a LDH and an siRNA specific for a PDHK.
    Type: Application
    Filed: May 31, 2018
    Publication date: February 7, 2019
    Inventors: Meixia ZHOU, Bradley Richard SNEDECOR, Chi Kin Domingos NG, Amy SHEN
  • Decreasing lactate level and increasing polypeptide production by downregulating the expression of lactate dehydrogenase and pyruvate dehydrogenase kinase
    Patent number: 10011856
    Abstract: The present invention provides methods and compositions for reducing lactate production and increasing polypeptide production in cultured cells. In one aspect, the invention provides a method comprising culturing cells expressing a) a small interfering RNA (siRNA) specific for a lactate dehydrogenase (LDH) and b) an siRNA specific for a pyruvate dehydrogenase kinase (PDHK). In another aspect, the invention provides cultured cells or vectors comprising an siRNA specific for a LDH and an siRNA specific for a PDHK.
    Type: Grant
    Filed: September 16, 2016
    Date of Patent: July 3, 2018
    Assignee: Genentech, Inc.
    Inventors: Meixia Zhou, Bradley Richard Snedecor, Chi Kin Domingos Ng, Amy Shen
  • PRODUCTION OF HETEROMULTIMERIC PROTEINS USING MAMMALIAN CELLS
    Publication number: 20170260252
    Abstract: Described herein are methods for the efficient production of antibodies and other multimeric protein complexes (collectively referred to herein as heteromultimeric proteins) capable of specifically binding to more than one target. The targets may be, for example, different epitopes located on a single molecule or located on different molecules.
    Type: Application
    Filed: November 4, 2016
    Publication date: September 14, 2017
    Applicant: Genentech, Inc.
    Inventors: JUSTIN SCHEER, WHITNEY SHATZ, DOMINGOS NG
  • DECREASING LACTATE LEVEL AND INCREASING POLYPEPTIDE PRODUCTION BY DOWNREGULATING THE EXPRESSION OF LACTATE DEHYDROGENASE AND PYRUVATE DEHYDROGENASE KINASE
    Publication number: 20170191102
    Abstract: The present invention provides methods and compositions for reducing lactate production and increasing polypeptide production in cultured cells. In one aspect, the invention provides a method comprising culturing cells expressing a) a small interfering RNA (siRNA) specific for a lactate dehydrogenase (LDH) and b) an siRNA specific for a pyruvate dehydrogenase kinase (PDHK). In another aspect, the invention provides cultured cells or vectors comprising an siRNA specific for a LDH and an siRNA specific for a PDHK.
    Type: Application
    Filed: September 16, 2016
    Publication date: July 6, 2017
    Inventors: Meixia ZHOU, Bradley Richard SNEDECOR, Chi Kin Domingos NG, Amy SHEN
  • Decreasing lactate level and increasing polypeptide production by downregulating the expression of lactate dehydrogenase and pyruvate dehydrogenase kinase
    Patent number: 9487809
    Abstract: The present invention provides methods and compositions for reducing lactate production and increasing polypeptide production in cultured cells. In one aspect, the invention provides a method comprising culturing cells expressing a) a small interfering RNA (siRNA) specific for a lactate dehydrogenase (LDH) and b) an siRNA specific for a pyruvate dehydrogenase kinase (PDHK). In another aspect, the invention provides cultured cells or vectors comprising an siRNA specific for a LDH and an siRNA specific for a PDHK.
    Type: Grant
    Filed: November 28, 2012
    Date of Patent: November 8, 2016
    Assignee: Genentech, Inc.
    Inventors: Meixia Zhou, Bradley Richard Snedecor, Chi Kin Domingos Ng, Amy Shen
  • Identification of a family of secreted proteins in vascular endothelium
    Patent number: 8211640
    Abstract: The invention relates to SCUBE molecules and generally to gene expression in vascular endothelial cells. The invention specifically relates to the discovery of a novel gene family containing the genes and proteins referred to herein as SCUBE1, SCUBE2 and SCUBE3 which can be expressed in endothelial cells. SCUBE proteins may be involved in the development of cardiovascular disease, hemostasis, thrombosis, inflammatory disease, bone metabolism disorders, urinary bladder disorders and breast disorders.
    Type: Grant
    Filed: December 18, 2008
    Date of Patent: July 3, 2012
    Assignee: Millennium Pharmaceuticals, Inc.
    Inventors: Ruey-Bing Yang, Chi Kin Domingos Ng, James E. Tomlinson, Laszlo G. Komuves, James N. Topper, Keith E. Robison
  • ANTIBODIES WITH ENHANCED ADCC FUNCTIONS
    Publication number: 20110039300
    Abstract: The present invention concerns antibodies with enhanced antibody-dependent cell mediated cytotoxicity (ADCC) and method for preparation thereof.
    Type: Application
    Filed: August 6, 2010
    Publication date: February 17, 2011
    Inventors: ROBERT BAYER, Amy Shen, Reed J. Harris, Domingos Ng
  • ANTIBODIES WITH ENHANCED ADCC FUNCTION
    Publication number: 20110003338
    Abstract: The present invention concerns antibodies enhanced antibody-dependent cell mediated cytotoxicity (ADCC) and method for preparation thereof.
    Type: Application
    Filed: March 11, 2009
    Publication date: January 6, 2011
    Inventors: Robert Bayer, Reed J. Harris, Feng Li, Domingos Ng, Efren Pacis, Amy Shen, Marcella Yu
  • Identification of a family of secreted proteins in vascular endothelium
    Publication number: 20090264361
    Abstract: The invention relates to SCUBE molecules and generally to gene expression in vascular endothelial cells. The invention specifically relates to the discovery of a novel gene family containing the genes and proteins referred to herein as SCUBE1, SCUBE2 and SCUBE3 which can be expressed in endothelial cells. SCUBE proteins may be involved in the development of cardiovascular disease, hemostasis, thrombosis, inflammatory disease, bone metabolism disorders, urinary bladder disorders and breast disorders.
    Type: Application
    Filed: December 18, 2008
    Publication date: October 22, 2009
    Inventors: Ruey-Bing Yang, Chi Kin Domingos Ng, James E. Tomlinson, Laszlo G. Komuves, James N. Topper, Keith E. Robison
  • Method of producing antibodies with improved function
    Publication number: 20090208500
    Abstract: The invention provides methods for controlling fucosylation levels and improving ADCC activity in antibodies.
    Type: Application
    Filed: June 5, 2006
    Publication date: August 20, 2009
    Applicant: Genentech, Inc.
    Inventors: John C. Joly, Henry B. Lowman, Domingos Ng, Amy Y. Shen, Bradley R. Snedecor
  • Identification of a family of secreted proteins in vascular endothelium
    Patent number: 7485431
    Abstract: The invention relates to SCUBE molecules and generally to gene expression in vascular endothelial cells. The invention specifically relates to the discovery of a novel gene family containing the genes and proteins referred to herein as SCUBE1, SCUBE2 and SCUBE3 which can be expressed in endothelial cells. SCUBE proteins may be involved in the development of cardiovascular disease, hemostasis, thrombosis, inflammatory disease, bone metabolism disorders, urinary bladder disorders and breast disorders.
    Type: Grant
    Filed: March 22, 2007
    Date of Patent: February 3, 2009
    Assignee: Millennium Pharmaceuticals, Inc.
    Inventors: Ruey-Bing Yang, Chi Kin Domingos Ng, James E. Tomlinson, Laszlo G. Komuves, James N. Topper, Keith E. Robison
  • Identification of a family of secreted proteins in vascular endothelium
    Patent number: 7258988
    Abstract: The invention relates to SCUBE molecules and generally to gene expression in vascular endothelial cells. The invention specifically relates to the discovery of a novel gene family containing the genes and proteins referred to herein as SCUBE1, SCUBE2 and SCUBE3 which can be expressed in endothelial cells. SCUBE proteins may be involved in the development of cardiovascular disease, hemostasis, thrombosis, inflammatory disease, bone metabolism disorders, urinary bladder disorders and breast disorders.
    Type: Grant
    Filed: April 3, 2003
    Date of Patent: August 21, 2007
    Assignee: Millennium Pharmaceuticals, Inc.
    Inventors: Ruey-Bing Yang, Chi Kin Domingos Ng, James E. Tomlinson, Laszlo G. Komuves, James N. Topper, Keith E. Robison
  • Identification of a family of secreted proteins in vascular endothelium
    Publication number: 20030219813
    Abstract: The invention relates to SCUBE molecules and generally to gene expression in vascular endothelial cells. The invention specifically relates to the discovery of a novel gene family containing the genes and proteins referred to herein as SCUBE1, SCUBE2 and SCUBE3 which can be expressed in endothelial cells. SCUBE proteins may be involved in the development of cardiovascular disease, hemostasis, thrombosis, inflammatory disease, bone metabolism disorders, urinary bladder disorders and breast disorders.
    Type: Application
    Filed: April 3, 2003
    Publication date: November 27, 2003
    Applicant: Millennium Pharmaceuticals, Inc.
    Inventors: Ruey-Bing Yang, Chi Kin Domingos Ng, James E. Tomlinson, Laszlo G. Komuves, James N. Topper, Keith E. Robison