Patents by Inventor Dominic DE SOUZA
Dominic DE SOUZA has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10975097Abstract: The present disclosure is directed to an improved process to convert crude ascomycin to purified pimecrolimus. Crude ascomycin is chlorinated with triphenylphosphine and N-chlorosuccinimide (NCS) to yield crude pimecrolimus, which is then purified further by HPLC and subsequent crystallization. The processes of the present disclosure enable the removal of close homologs of pimecrolimus by high-pressure liquid chromatography without prior purification of the ascomycin starting material. This improvement may make the conversion of ascomycin to pimecrolimus industrially applicable and less expensive.Type: GrantFiled: May 2, 2018Date of Patent: April 13, 2021Inventors: Borut Gabriel, Alja{hacek over (z)} Kajtna, Ajna Lukic, Dominic De Souza, Werner Hasselwander
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Publication number: 20200079792Abstract: The present disclosure is directed to an improved process to convert crude ascomycin to purified pimecrolimus. Crude ascomycin is chlorinated with triphenylphosphine and N-chlorosuccinimide (NCS) to yield crude pimecrolimus, which is then purified further by HPLC and subsequent crystallization. The processes of the present disclosure enable the removal of close homologs of pimecrolimus by high-pressure liquid chromatography without prior purification of the ascomycin starting material. This improvement may make the conversion of ascomycin to pimecrolimus industrially applicable and less expensive.Type: ApplicationFiled: May 2, 2018Publication date: March 12, 2020Inventors: Borut Gabriel, Aljaz Kajtna, Ajna Lukic, Dominic De Souza, Werner Hasselwander
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Patent number: 9206146Abstract: The present invention relates to a process for the preparation of a hydrogen chloride (HCl) salt of a compound of formula (I) wherein Y1 and Y2 are independently F or Cl, preferably F, said compound of formula (I) containing the cis-isomer and the trans-isomer, wherein the process comprises (1) providing the compound of formula (I) comprised in a first suitable solvent; and (2) treating the compound of formula (I) comprised in the first suitable solvent with HCl comprised in a second suitable solvent to obtain the HCl salt of the compound of formula (I).Type: GrantFiled: May 18, 2011Date of Patent: December 8, 2015Assignee: SANDOZ AGInventors: Martin Langner, Dominic De Souza, Abhinay C. Pise, Sachin Bhuta
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Patent number: 9199919Abstract: The present invention relates to a process for the preparation of a chiral compound according to formula (V) wherein R1 is preferably an alkyl residue preferably having from 1 to 6 carbon atoms, in particular to a process for the preparation of a chiral compound the crystalline chiral compounds as such, and their use for the preparation of an antifungal agent, in particular posaconazole.Type: GrantFiled: May 18, 2011Date of Patent: December 1, 2015Assignee: SANDOZ AGInventors: Martin Albert, Dominic De Souza, Joerg Salchenegger, Michael Oberhuber
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Patent number: 9073904Abstract: The present invention relates to process for the preparation of a chiral compound of formula (IX) or a salt thereof, wherein Y1 and Y2 are independently F or Cl, preferably F, the crystalline compound of formula (IX) as such, and its use for the preparation of an antifungal agent.Type: GrantFiled: May 18, 2011Date of Patent: July 7, 2015Assignee: SANDOZ AGInventors: Dominic De Souza, Shreerang V. Joshi, Sachin Bhuta, Abhinay C. Pise, Dattatraya N. Chavan, Shashikant D. Metkar
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Patent number: 9040539Abstract: A process for the preparation of a chiral compound, in particular posaconazole, wherein the process comprises mixing and reacting the compounds of formula (I) Y3—NH2; of formula (IIa) 0=C?N—Y0 and/or of formula (IIb) and of formula (III) in a solvent in any order to obtain a reaction mixture containing a chiral compound of formula (IV) and/or formula (V).Type: GrantFiled: May 18, 2011Date of Patent: May 26, 2015Assignee: SANDOZ AGInventors: Michael Oberhuber, Joerg Salchenegger, Dominic De Souza, Martin Albert, Thorsten Wilhelm, Martin Langner, Hubert Sturm, Hans-Peter Spitzenstaetter
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Patent number: 8772544Abstract: The present invention relates to a process for the purification of crude bimatoprost to obtain pure bimatoprost comprising a chromatography, preferably a chromatography using an achiral stationary phase and an eluent comprising an alcohol and an apolar solvent; and crystallization of the product obtained the chromatography to obtain pure bimatoprost.Type: GrantFiled: June 10, 2009Date of Patent: July 8, 2014Assignee: Sandoz AGInventors: Dominic De Souza, Martin Albert, Hubert Sturm
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Patent number: 8648189Abstract: The present invention relates to the use of a compound having the formula (II) for the preparation of a compound having the formula (V). Methods of preparing the compound having the formula (V) using the compound having the formula (II) are also described. Individual reaction steps as well as intermediates are additionally claimed.Type: GrantFiled: February 10, 2011Date of Patent: February 11, 2014Assignee: Sandoz AGInventors: Hubert Sturm, Dominic De Souza, Kerstin Knepper, Martin Albert
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Patent number: 8546112Abstract: The present invention relates to processes for the preparation of 5-methyl-3-nitromethyl-hexanoic acid ester and its salts. Also disclosed are processes for the preparation of 5-methyl-3-nitromethyl-hexanoic acid salt and a process for the preparation of 3-(aminomethyl)-5-methylhexanoic acid. (S)-5-Methyl-3-nitromethyl-hexanoic acid or (R)-5-methyl-3-nitromethyl-hexanoic acid in enantioenriched form or enantiopure form as well as salts thereof, (S)-5-methyl-3-nitromethyl-hexanoic acid ester or (R)-5-methyl-3-nitromethyl-hexanoic acid ester in enantioenriched form or enantiopure form and a compound, namely Formula (XIII), in racemic form, enantioenriched form or enantiopure form are also disclosed.Type: GrantFiled: May 19, 2009Date of Patent: October 1, 2013Assignee: Sandoz AGInventors: Martin Albert, Ferdinand Zepeck, Andreas Berger, Waander Riethorst, Helmut Schwab, Daniel Luschnig, Peter Remler, Joerg Salchenegger, Doris Osl, Dominic De Souza
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Publication number: 20130210833Abstract: A process for the preparation of a chiral compound, in particular posaconazole, wherein the process comprises mixing and reacting the compounds of formula (I) Y3—NH2; of formula (IIa) 0=C?N—Y0 and/or of formula (IIb) and of formula (III) in a solvent in any order to obtain a reaction mixture containing a chiral compound of formula (IV) and/or formula (V).Type: ApplicationFiled: May 18, 2011Publication date: August 15, 2013Applicant: Sandoz AGInventors: Michael Oberhuber, Joerg Salchenegger, Dominic De Souza, Martin Albert, Thorsten Wilhelm, Martin Langner, Hubert Sturm, Hans-Peter Spitzenstaetter
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Publication number: 20130211086Abstract: The present invention relates to a process for the preparation of a hydrogen chloride (HCl) salt of a compound of formula (I) wherein Y1 and Y2 are independently F or Cl, preferably F, said compound of formula (I) containing the cis-isomer and the trans-isomer, wherein the process comprises (1) providing the compound of formula (I) comprised in a first suitable solvent; and (2) treating the compound of formula (I) comprised in the first suitable solvent with HCl comprised in a second suitable solvent to obtain the HCl salt of the compound of formula (I).Type: ApplicationFiled: May 18, 2011Publication date: August 15, 2013Applicant: SANDOZ AGInventors: Martin Langner, Dominic De Souza, Abhinay C. Pise, Sachin Bhuta
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Publication number: 20130203993Abstract: The present invention relates to a process for the preparation of a chiral compound according to formula (V) wherein R1 is preferably an alkyl residue preferably having from 1 to 6 carbon atoms, in particular to a process for the preparation of a chiral compound the crystalline chiral compounds as such, and their use for the preparation of an antifungal agent, in particular posaconazole.Type: ApplicationFiled: May 18, 2011Publication date: August 8, 2013Applicant: SANDOZ AGInventors: Martin Albert, Dominic De Souza, Joerg Salchenegger, Michael Oberhuber
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Publication number: 20130203994Abstract: The present invention relates to process for the preparation of a chiral compound of formula (IX) or a salt thereof, wherein Y1 and Y2 are independently F or Cl, preferably F, the crystalline compound of formula (IX) as such, and its use for the preparation of an antifungal agent.Type: ApplicationFiled: May 18, 2011Publication date: August 8, 2013Applicant: SANDOZ AGInventors: Dominic De Souza, Shreerang V. Joshi, Sachin Bhuta, Abhinay C. Pise, Dattatraya N. Chavan, Shashikant D. Metkar
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Publication number: 20130184457Abstract: The present invention relates to the use of a compound having the formula (II) for the preparation of a compound having the formula (V). Methods of preparing the compound having the formula (V) using the compound having the formula (II) are also described. Individual reaction steps as well as intermediates are additionally claimed.Type: ApplicationFiled: February 10, 2011Publication date: July 18, 2013Applicant: SANDOZ AGInventors: Hubert Sturm, Dominic De Souza, Kerstin Knepper, Martin Albert
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Patent number: 8481758Abstract: The present invention relates to an improved process for the production of prostaglandins and prostaglandin analogs. In particular, this invention relates to the production of prostaglandins of the PGF2?-series, including latanoprost, travoprost, and bimatoprost, which are active pharmaceutical ingredients used for the reduction of elevated intra-ocular pressure in patients with glaucoma and ocular hypertension.Type: GrantFiled: July 10, 2009Date of Patent: July 9, 2013Assignee: Sandoz AGInventors: Martin Albert, Andreas Berger, Dominic De Souza, Kerstin Knepper, Hubert Sturm
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Publication number: 20120165541Abstract: The present invention relates to method for the preparation of an ?-amino-alkane(thio)amide having the general formula (6) Furthermore, novel intermediates and partial reaction steps of the claimed method are disclosed.Type: ApplicationFiled: July 30, 2010Publication date: June 28, 2012Inventors: Martin Albert, Dominic De Souza
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Publication number: 20110178340Abstract: The present invention relates to a process for the purification of crude bimatoprost to obtain pure bimatoprost comprising a chromatography, preferably a chromatography using an achiral stationary phase and an eluent comprising an alcohol and an apolar solvent; and crystallisation of the product obtained the chromatography to obtain pure bimatoprost.Type: ApplicationFiled: June 10, 2009Publication date: July 21, 2011Applicant: SANDOZ AGInventors: Dominic De Souza, Martin Albert, Hubert Sturm
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Publication number: 20110040078Abstract: The present invention relates to a process for the preparation of erythromysin derivatives, in particular telithromycin of formula (I) and its pharmaceutically acceptable salts, providing the isolated intermediates in crystalline form of superior stability and purity.Type: ApplicationFiled: October 10, 2008Publication date: February 17, 2011Applicants: SANDOZ AGInventors: Ingolf Macher, Dominic de Souza
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Publication number: 20100010239Abstract: The present invention relates to an improved process for the production of prostaglandins and prostaglandin analogs. In particular, this invention relates to the production of prostaglandins of the PGF2?-series, including latanoprost, travoprost, and bimatoprost, which are active pharmaceutical ingredients used for the reduction of elevated intra-ocular pressure in patients with glaucoma and ocular hypertension.Type: ApplicationFiled: July 10, 2009Publication date: January 14, 2010Applicant: Sandoz AGInventors: Martin ALBERT, Andreas BERGER, Dominic DE SOUZA, Kerstin KNEPPER, Hubert STURM