Abstract: The disclosure provides compositions and methods for treating multiple myeloma. In some embodiments, the compositions comprise (E)-3-hydroxy-21-[2?-(N,N-dimethylamino)ethoxy]-19-norpregna-1,3,5(10),17(20)-tetraene or a pharmaceutically acceptable salt or prodrug thereof and a pharmaceutical carrier.

Abstract: The disclosure provides compositions and methods for treating multiple myeloma. In some embodiments, the compositions comprise (E)-3-hydroxy-21-[2?-(N,N-dimethylamino)ethoxy]-19-norpregna-1,3,5(10),17(20)-tetraene or a pharmaceutically acceptable salt or prodrug thereof and a pharmaceutical carrier.

Abstract: A conduit for use with a blood pump can have a flared inner surface at an end of the conduit. In some embodiments, the conduit can include a strain relief member such as overmolded silicone. The strain relief member can maintain the profile of the flared inner surface. A conduit with a flared inner surface can be configured for connection to a blood pump via a connector. For example, the conduit can include an anchor member such as flange configured to engage with various components of a connector to connect the conduit to a fitting on a pump or another structure. In some embodiments, the conduit can be configured to connect to a blood conduit connector including a member such as a compression collet and a fitting such as a coupler. The connector can include a bayonet connection to facilitate rapid connection and disconnection of the conduit from a fitting.