Abstract: Methods and kits for detecting a freely diffusing small molecule aldehyde in a subject or in a sample from a subject are described herein, comprising administering an aldehyde-binding compound of Formula I to the subject, or combining such a compound with the sample; and detecting the product of the compound of Formula I and the aldehyde. Detection of the product may involve imaging, such as MRI, CEST-MRI or positron emission tomography (PET) imaging; or may involve fluorescence or an electrochemical detection method. Relevant aldehydes detected according to the described method can be used to determine the presence or severity of a concussion in a subject.

Abstract: Methods and apparatus for recoating parameter control are disclosed. An example apparatus disclosed herein includes a blade holder, a blade, and a control element disposed within the blade holder, the control element to move the blade between a first position and a second position, the apparatus having a first stiffness when the blade is in the first position, the apparatus having a second stiffness when the blade is in the second position, the first stiffness greater than the second stiffness.

Abstract: A method may of additively manufacturing a three-dimensional object includes determining a plurality of scanning segments for a build plane and/or for one or more object layers respectively corresponding to one or more regions of a powder bed defining the build plane, and determining an irradiation vector for irradiating the scanning segments with an energy beam. The irradiation vector determined for the respective scanning segments may include a hatching vector and/or a plurality of scanning vectors defining the hatching vector. The hatching vector and/or the scanning vectors defining the hatching vector may be oriented away from a normal point on the build plane. The method may include outputting an irradiation control command to an energy beam system based on the scanning segments and/or the irradiation vector for irradiating the scanning segments.

Abstract: A method of calibrating an additive manufacturing machine may include comparing a calibration image to a reference image and performing a calibration operation based at least in part on the comparison. The reference image and the calibration image may be determined from image data obtained by an imaging system included as part of or associated with an additive manufacturing machine. The reference image may portray a reference pattern having been irradiated upon a build plane of the additive manufacturing machine by a first beam generation device, and the calibration image may portray a calibration pattern having been irradiated upon the build plane of the additive manufacturing machine using a second beam generation device. The calibration operation may include calibrating an energy beam system that includes the first beam generation device and/or the second beam generation device, and/or the calibration operation may include calibrating the imaging system.

Abstract: An apparatus for additively manufacturing three-dimensional objects may include at least one calibration unit, at least one irradiation device, and a determination device. The least one calibration unit may include at least one calibration region arranged in the beam guiding plane, and the at least one calibration region may include a plurality of sub-regions differing in respect of at least one optical property. The at least one irradiation device may be configured to guide a plurality of energy beams across the at least one calibration region comprising the plurality of sub-regions, and a plurality of calibration signals may be generated by the plurality of sub-regions being irradiated with the plurality of energy beams. The determination device may be configured to determine the plurality of calibration signals and to determine a calibration status of the irradiation device based at least in part on the determined plurality of calibration signals.

Abstract: Methods of calibrating an apparatus for additively manufacturing three-dimensional objects include performing a defined movement pattern with at least one beam guiding unit for guiding an energy beam along a defined beam path. The defined movement pattern may include at least one sky writing section and at least one irradiation section. The apparatus may include at least one irradiation device adapted to guide the energy beam across a beam guiding plane. An exemplary method may additionally include, generating a melt pool along the irradiation section, determining a melt pool signal via a determination device of the apparatus, comparing the position of the origin of the melt pool signal in the beam guiding plane with the irradiation section, and determining a calibration status based on the comparison result.

Abstract: A blade for a gas turbine is described, the blade comprising a trailing edge and a trailing edge cooling channel extending from a first upstream end to a second downstream end, in which the width of the trailing edge cooling channel in the direction perpendicular to the camber line of the blade varies and the narrowest width in the trailing edge cooling channel is at the first upstream end, so as to provide a blade where the trailing edge can be removed with a minimal change or no change in the cooling flow capacity through the trailing edge cooling channel. Related methods are also described.

Abstract: Apparatus for additively manufacturing three-dimensional objects by means of successive layerwise selective irradiation and consolidation of layers of a build material which can be consolidated by means of an energy beam, comprising an irradiation device is adapted to generate the energy beam and guide the energy beam over a determination plane, in particular a build plane in which the build material is applied to be irradiated, wherein the irradiation device is adapted to generate at least one irradiation region, in particular a melt pool, in the determination plane, wherein a determination device is provided that is adapted to determine a focal position of the energy beam and/or a difference between a reference focal position and an actual focal position of the energy beam based on radiation that is emitted from at least one irradiation region.

Abstract: Power systems are disclosed. The power system may include a turbine component of a gas turbine system, and a computing device(s) in communication with the power plant. The computing device(s) may be configured to control the power plant system by performing various processes including defining a turbine inlet temperature range for a combustion gas flowing through the turbine component of the gas turbine system. The turbine inlet temperature range may be based on a desired operational load for the power plant system. The processes performed by the computing device(s) may also include determining fuel and maintenance cost ranges based on the turbine inlet temperature range, calculating a desired turbine inlet temperature range for the combustion gas based on the determined fuel and maintenance cost range, and adjusting an actual turbine inlet temperature of the combustion gas to be within the calculated, desired turbine inlet temperature range.

Abstract: Power systems are disclosed. The power system may include a turbine component of a gas turbine system, and a computing device(s) in communication with the power plant. The computing device(s) may be configured to control the power plant system by performing various processes including defining a turbine inlet temperature range for a combustion gas flowing through the turbine component of the gas turbine system. The turbine inlet temperature range may be based on a desired operational load for the power plant system. The processes performed by the computing device(s) may also include determining fuel and maintenance cost ranges based on the turbine inlet temperature range, calculating a desired turbine inlet temperature range for the combustion gas based on the determined fuel and maintenance cost range, and adjusting an actual turbine inlet temperature of the combustion gas to be within the calculated, desired turbine inlet temperature range.

Abstract: A blade for a gas turbine is described, the blade comprising a trailing edge and a trailing edge cooling channel extending from a first upstream end to a second downstream end, in which the width of the trailing edge cooling channel in the direction perpendicular to the camber line of the blade varies and the narrowest width in the trailing edge cooling channel is at the first upstream end, so as to provide a blade where the trailing edge can be removed with a minimal change or no change in the cooling flow capacity through the trailing edge cooling channel. Related methods are also described.