Abstract: The invention relates to a method and a device device for converting at least one reactant(5) into a reaction product and separating the at least one reactant from the reaction product, wherein the device comprises a vessel(10) with a vessel inner volume (11) and a confinement (20) submerged in the vessel inner volume (11), the confinement (20) providing a confinement inner (21) volume which is in fluid connection with the vessel inner volume (11), wherein the vessel inner volume (11) contains a first fluid (1) with a first density p1 and a second fluid with a second density p2, with p1 > p2, so that the first fluid (1) forms a lower phase and the second fluid (2) forms an upper phase in the vessel inner volume (11), wherein the confinement contains a third fluid (3) with a third density p3 with p3 > p2 so that the second fluid forms an upper layer and the third fluid forms a lower layer in the confinement inner volume (21), wherein the third fluid may be the same as or different from and is physically

Abstract: A method for producing a chiral amine may include performing a transamination reaction of a prochiral amino acceptor and an amino donor in a first solution in the presence of a transaminase, thereby forming a chiral amine and a co-product in the first solution. The amino donor is a high molecular weight (HMW) amino donor. In some examples, the molecular weight of the HMW amino donor is at least 150 g/mol. In some examples, the amino donor is affixed on a support, the total molecular weight of the amino donor and the support being at least 150 g/mol.

Abstract: A method for producing a chiral amine may include performing a transamination reaction of a prochiral amino acceptor and an amino donor in a first solution in the presence of a transaminase, thereby forming a chiral amine and a co-product in the first solution. The amino donor is a high molecular weight (HMW) amino donor. In some examples, the molecular weight of the HMW amino donor is at least 150 g/mol. In some examples, the amino donor is affixed on a support, the total molecular weight of the amino donor and the support being at least 150 g/mol.

Abstract: A membrane based separation method is for the separation or enrichment of one or more unsaturated compounds from mixtures of chemically similar organic compounds having a different degree of unsaturation, using a membrane, such as an inorganic membrane, functionalized with a metal, such as silver. An inorganic membrane, preferably modified or grafted with an organic functional group, is further functionalized with a metal, such as silver, for use in the membrane based separation methods.

Abstract: A membrane based process separates amines or organic acids from a solution containing at least one amine or at least one organic acid according to their hydrophobic properties. The more hydrophobic amine or organic acid passes the hydrophobic membrane into an acidic aqueous solution, thus selectively removing the amine or organic acid from the first solution. The process is particularly suitable to obtain chiral amines in high yield. A transaminase-catalyzed transamination of an amino donor and amino acceptor is combined with a hydrophobic membrane separation of the produced chiral amine. The selective removal of the chiral amine from the reaction mixture promotes the further transformation of the amino acceptor into the product chiral amine.

Abstract: A membrane based separation method is for the separation or enrichment of one or more unsaturated compounds from mixtures of chemically similar organic compounds having a different degree of unsaturation, using a membrane, such as an inorganic membrane, functionalized with a metal, such as silver. An inorganic membrane, preferably modified or grafted with an organic functional group, is further functionalized with a metal, such as silver, for use in the membrane based separation methods.

Abstract: Provided herein are processes for carrying out a chemical reaction of a substrate in a diluted reaction mixture. The processes include conducting the reaction mixture having reaction product and solvent to a filtration membrane which is permeable to the solvent but impermeable to the reaction product. Solvent which permeates the filtration membrane for dilution of the substrate feed is recycled.

Abstract: Disclosed is a process for carrying out a cyclization reaction, a polymerization reaction, an enzymatic reaction showing substrate inhibition, an enzymatic reaction showing product inhibition, a reaction showing precipitation of the substrate or of a reactant, the process comprising the steps of a) diluting a fresh substrate with solvent to form a diluted substrate-solvent mixture, and supplying this mixture to a reactor, b) causing the reaction medium in the reactor to react, c) discharging reaction mixture comprising reaction product, solvent, and substrate that has not reacted, to a first filtration membrane which is permeable to the solvent and impermeable to the substrate and to the catalyst or at least one of the reactants, d) returning solvent from the permeate side of the first membrane to dilute the fresh substrate, and e) returning retentate comprising substrate which has not reacted, from the first filtration membrane to the reactor.

Abstract: A membrane based process separates amines or organic acids from a solution containing at least one amine or at least one organic acid according to their hydrophobic properties. The more hydrophobic amine or organic acid passes the hydrophobic membrane into an acidic aqueous solution, thus selectively removing the amine or organic acid from the first solution. The process is particularly suitable to obtain chiral amines in high yield. A transaminase-catalyzed transamination of an amino donor and amino acceptor is combined with a hydrophobic membrane separation of the produced chiral amine. The selective removal of the chiral amine from the reaction mixture promotes the further transformation of the amino acceptor into the product chiral amine.

Abstract: Provided herein are processes for carrying out a chemical reaction of a substrate in a diluted reaction mixture. The processes include conducting the reaction mixture having reaction product and solvent to a filtration membrane which is permeable to the solvent but impermeable to the reaction product. Solvent which permeates the filtration membrane for dilution of the substrate feed is recycled.