Patents by Inventor Dominic Reynolds

Dominic Reynolds has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Beta-carbolines useful for treating inflammatory disease
    Patent number: 7727985
    Abstract: This invention provides beta-carboline compounds of formula I: wherein Ring A is a substituted pyridinyl, pyrimidinyl, morpholinyl, piperidinyl, piperazinyl, pyrrolidinyl, pyranyl, tetrahydrofuranyl, cyclohexyl, cyclopentyl or thiomorpholinyl ring and R1, R2 and R3 are as described in the specification. The compounds are IKK-2 inhibitors that are useful for treating IKK-2-mediated diseases such as inflammatory diseases and cancer.
    Type: Grant
    Filed: April 9, 2004
    Date of Patent: June 1, 2010
    Assignee: Millennium Pharmaceuticals, Inc.
    Inventors: Michael E. Hepperle, Julie Fields Liu, Francois Soucy, Yingchun Ye, Robert S. Murray, Raman Prakash, Jeremy D. Little, Alfredo Castro, Hormoz Mazdiyasni, Paul E. Fleming, Dominic Reynolds
  • BETA-CARBOLINES USEFUL FOR TREATING INFLAMMATORY DISEASE
    Publication number: 20100093713
    Abstract: This invention provides beta-carboline compounds of formula wherein Ring A is a substituted pyridinyl, pyrimidinyl, morpholinyl, piperidinyl, piperazinyl, pyrrolidinyl, pyranyl, tetrahydrofuranyl, cyclohexyl, cyclopentyl or thiomorpholinyl ring and R1, R2 and R3 are as described in the specification. The compounds are IKK-2 inhibitors that are useful for treating IKK-2-mediated diseases such as inflammatory diseases and cancer.
    Type: Application
    Filed: December 17, 2009
    Publication date: April 15, 2010
    Applicant: Millennium Pharmaceuticals, Inc.
    Inventors: Michael E. Hepperle, Julie Fields Liu, Francois Soucy, Yingchun Ye, Robert S. Murray, Raman Prakash, Jeremy D. Little, Alfredo Castro, Hormoz Mazdiyasni, Paul E. Fleming, Dominic Reynolds
  • PGD2 receptor antagonists for the treatment of inflammatory diseases
    Publication number: 20090181966
    Abstract: Disclosed herein are compounds represented by Structural Formula (I) and (I-A): Also disclosed is the use of such compounds for inhibiting the G-protein coupled receptor referred to as chemoattractant receptor-homologous molecule expressed on Th2, or simply “CRTH2” for the treatment of inflammatory disorders. The variables in Structural Formula (I) and (I-A) are defined herein.
    Type: Application
    Filed: January 27, 2009
    Publication date: July 16, 2009
    Applicant: Millennium Pharmaceuticals, Inc.
    Inventors: Shomir Ghosh, Amy M. Elder, Kenneth G. Carson, Kevin T. Sprott, Sean J. Harrison, Frederick A. Hicks, Christelle C. Renou, Dominic Reynolds
  • PGD2 receptor antagonists for the treatment of inflammatory diseases
    Patent number: 7504508
    Abstract: Disclosed herein are compounds represented by Structural Formula (I) and (I-A): Also disclosed is the use of such compounds for inhibiting the G-protein coupled receptor referred to as chemoattractant receptor-homologous molecule expressed on Th2, or simply “CRTH2” for the treatment of inflammatory disorders. The variables in Structural Formula (I) and (I-A) are defined herein.
    Type: Grant
    Filed: April 7, 2005
    Date of Patent: March 17, 2009
    Assignee: Millennium Pharmaceuticals, Inc.
    Inventors: Shomir Ghosh, Amy M. Elder, Kenneth G. Carson, Kevin T. Sprott, Sean J. Harrison, Frederick A. Hicks, Christelle C. Renou, Dominic Reynolds
  • PGD2 receptor antagonists for the treatment of inflammatory diseases
    Publication number: 20050256158
    Abstract: Disclosed herein are compounds represented by Structural Formula (I) and (I-A): Also disclosed is the use of such compounds for inhibiting the G-protein coupled receptor referred to as chemoattractant receptor-homologous molecule expressed on Th2, or simply “CRTH2” for the treatment of inflammatory disorders. The variables in Structural Formula (I) and (I-A) are defined herein.
    Type: Application
    Filed: April 7, 2005
    Publication date: November 17, 2005
    Inventors: Shomir Ghosh, Amy Elder, Kenneth Carson, Kevin Sprott, Sean Harrison, Frederick Hicks, Christelle Renou, Dominic Reynolds
  • Beta-carbolines useful for treating inflammatory disease
    Publication number: 20050239781
    Abstract: This invention provides beta-carboline compounds of formula III-A-aa: wherein Q, G, R1, R2, R3, and R6b are as described in the specification. The compounds are useful for treating diseases such as inflammatory diseases and cancer.
    Type: Application
    Filed: April 8, 2005
    Publication date: October 27, 2005
    Inventors: Michael Hepperle, Julie Liu, Francois Soucy, Prakash Raman, Jeremy Little, Paul Fleming, Dominic Reynolds, Geraldine Harriman
  • Beta-carbolines useful for treating inflammatory disease
    Publication number: 20040235839
    Abstract: This invention provides beta-carboline compounds of formula I: 1
    Type: Application
    Filed: April 9, 2004
    Publication date: November 25, 2004
    Applicant: Millennium Pharmaceuticals, Inc.
    Inventors: Michael E. Hepperle, Julie Fields Liu, Francois Soucy, Yingchun Ye, Robert S. Murray, Raman Prakash, Jeremy D. Little, Alfredo Castro, Hormoz Mazdiyasni, Paul E. Fleming, Dominic Reynolds