Abstract: This invention relates to the use of cyclopropylamine derivatives for the modulation, notably the inhibition of the activity of Lysine-specific demethylase 1 (LSD1). Suitably, the present invention relates to the use of cyclopropylamines in the treatment of cancer.

Abstract: Herein are disclosed azaindazoles of formula (I) where the various groups are defined herein, and which are useful for treating cancer.

Abstract: Herein are disclosed azaindazoles of formula (I) where the various groups are defined herein, and which are useful for treating cancer.

Abstract: Herein are disclosed azaindazoles of formula (I) where the various groups are defined herein, and which are useful for treating cancer.

Abstract: Herein are disclosed azaindazoles of formula (I) where the various groups are defined herein, and which are useful for treating cancer.

Abstract: Insecticidal (dihalopropenyl) phenylalkyl substituted dihydrobenzofuran and dihydrobenzopyran derivatives of Formula I are disclosed. These compounds provide unexpected insecticidal activity across a spectrum of insect pests combined with desirable physical properties including improved photostability. wherein x and y are integers independently selected from 0 or 1; and B is a bridging group *—(CR16R17)q—(CR18R19)r—(CR20R21)s-Lt-(CR22R23)u—(CR24R25)v—(CR26R27)w—, where the asterisk denotes attachment at A; and q, r, s, u, v and w are integers independently selected from 0, 1 and 2; and t is an integer selected from 0 and 1. A, D, E, G, M, R through R11, and R16 through R27, inclusively, are fully described herein. In addition, compositions comprising an insecticidally effective amount of at least one compound of formula I and methods of controlling insects by applying said compositions to a locus where insects are present or are expected to be present are also disclosed.

Abstract: Certain novel (dihalopropenyl)phenylalkyl substituted benzoxazole and benzothiazole derivatives have unexpected insecticidal activity. These compounds are represented by formula (I): where R through R11, inclusively. x, A, B, y, D, E and G are fully described herein. Preferred compounds of the present invention are those wherein the benzo-fused ring moiety is attached to the remainder of the molecule at the positions designated as (5) or (6) and where R11 is either C1-C3 alkyl or halo C1-C3 alkyl. In addition, compositions comprising an insecticidally effective amount of at least one compound of formula (I), and optionally, an effective amount of at least one of a second compound, with at least one insecticidally compatible carrier are also disclosed; along with methods of controlling insects comprising applying said compositions to a locus where insects are present or are expected to be present.

Abstract: It has now been found that certain novel benzyloxyphenyl-substituted heterocycles are useful as pre-emergent and post-emergent herbicides. These compounds are represented by formula I: ##STR1## where Q is 1-substituted-6-trifluoromethyl-2,4(1H,3H)-pyrimidinedion-3 -yl, 4-difluoromethyl-4,5-dihydro-3-methyl-1,2,4-triazol-5(1H)-on-1-yl, 4-halo-5-difluoromethoxy-1-methylpyrazol-3-yl, a 3,4,5,6-tetrahydrophthalimid-1-yl, 8-thia-1,6-diazabicyclo?4.3.0!-nonane-7-on-9-iminoyl, 4-methyl-1,2,4-triazine-3,5-dion-2-yl, 3-chloro-4,5,6,7-tetrahydroindazol-2-yl, 1,4-dihydro-4-(3-fluoropropyl)-5H-tetrazole-5-on-1-yl or a 5,6,7,8-tetrahydro-1,2,4-triazolo-?4,3-a!pyridin-3(2H)-on-2-yl moiety; Z is oxygen, sulfur or CH.sub.2 ; n is 0 or 1, and W, X, Y, R, and R.sup.1 are as described in the specification. Preferred are those compounds where W is oxygen; X is hydrogen or fluoro; Y is methyl or ethyl; n is 1; Z is oxygen; R is methyl; and R.sup.1 is hydroxyalkyl or CH.sub.2 OCONHCH.sub.3.