Abstract: An example method is provided for maintaining stability to an injury defined by a separation of two bones (e.g., the tibia and fibula), the separation being an injured distance greater than a pre-injury distance between the two bones in a first human patient. The method may include delivering a first apparatus for approximation of the two bones in the first human patient comprising the injury, the first apparatus including a flexible segment disposed between a first anchor and a second anchor. The method may further include maintaining, by the first apparatus, a restored distance between the two bones in the first human patient after a repetitive dynamic loading, the restored distance approximately equal to the pre-injury distance.

Abstract: Provided is a cartridge assembly having first and second cartridges sealed by an interface member having a first sealing member along a radially outer surface thereof having a non-planar geometry around the outer surface and a second sealing member along the radially outer surface having a non-planar geometry around the outer surface. The sealing members may each have a repeating, undulating, non-planar geometry around the outer surface. The cartridges have ends with matching geometries to allow the cartridges to engage in surface-to-surface relation around their entire extents to create with the interface member an air tight seal.

Abstract: Provided is a cartridge assembly having first and second cartridges sealed by an interface member having a first sealing member along a radially outer surface thereof having a non-planar geometry around the outer surface and a second sealing member along the radially outer surface having a non-planar geometry around the outer surface. The sealing members may each have a repeating, undulating, non-planar geometry around the outer surface. The cartridges have ends with matching geometries to allow the cartridges to engage in surface-to-surface relation around their entire extents to create with the interface member an air tight seal.

Abstract: A system for optimising electronic circuits to be designed has two parts or phases, a training phase 10 in which optimisation scenarios for selected electronic circuits are derived using an evolutionary algorithm, and an operation phase 11, in which the derived optimisation scenarios are used to optimise new electronic circuits to be designed. The training phase 10 uses an evolutionary algorithm to produce a specialised and relatively fast optimisation scenario for each of a plurality of input circuits or groups of circuits (step 13). One or more of the evolved specialist optimisation scenarios are then selected to form a suite of optimisation scenarios (step 15) for use to optimise new circuits to be designed. In the operation phase 11, a new circuit to be optimised is input at step 18, and a plurality of optimisation scenarios from the suite of optimisation scenarios 15 is then used to try to optimise the new circuit (step 19).