Abstract: Evolved sortases exhibiting enhanced reaction kinetics and/or altered substrate preferences are provided herein, for example evolved sortases that bind recognitions motifs comprising a LMVGG [SEQ ID NO: 3] sequence. Also provided are methods (e.g., orthogonal transpeptidation and diagnostics methods) for using such sortases.

Abstract: A system includes a memory and a queue manager that maintains a virtual queue in the memory for a consumable event. The virtual queue defines a current order of a plurality of a first class of agents for the consumable event. The queue manager is configured to summon one or more agents of the plurality of the first class of agents to the consumable event, and output an instruction to one or more agents of a plurality of a second class of agents configured to perform one or more actions related to the consumable event, wherein the queue manager is configured to communicate with a plurality of mobile devices, each mobile device of the plurality of mobile devices associated with an agent of the plurality of the first class of agents and to communicate with the plurality of the second class of agents.

Abstract: Binding polypeptides (e.g., antibodies and antigen-binding fragments thereof) that specifically bind one or more species of soluble, AD brain-derived synaptotoxic amyloid beta (A?) without binding to classical monomeric, protofibrillar or fibrillar A?, are provided. Pharmaceutical compositions comprising binding polypeptides that specifically bind one or more species of soluble, synaptotoxic A? are provided. Methods of making binding polypeptides that specifically bind one or more species of soluble, synaptotoxic A? are provided. Methods of treating Alzheimer's disease using binding polypeptides that specifically bind one or more species of soluble, synaptotoxic A? are provided. Methods of reducing one or more symptoms of Alzheimer's disease using binding polypeptides that specifically bind one or more species of soluble, synaptotoxic A? are provided.

Abstract: The present invention provides a system that comprises a memory and a queue manager that maintains a virtual queue in the memory for a consumable event, the virtual queue defining a current order of a plurality of agents, and summons one or more agents of the plurality of agents to the consumable event, wherein the queue manager is configured to communicate with a plurality of mobile devices, each mobile device of the plurality of mobile devices associated with an agent of the plurality of agents, wherein the queue manager communicates with each mobile device in order to monitor the associated agent, and wherein the queue manager is configured to dynamically determine when to summon one or more agents of the plurality of agents in the virtual queue to the consumable event based on the monitoring of the plurality of agents.

Abstract: Systems, computer-readable media, and methods for performing a reservoir simulation by obtaining reservoir data; translating the reservoir data into grid properties to create a grid; dividing the grid into domains; generating coarse grids corresponding to each domain; processing the domains, where processing a domain includes: calculating pressure for the domain using a coarse grid corresponding to the domain, calculating flux for the domain using a coarse grid corresponding to the domain, and calculating transport of fluids for the domain using a coarse grid corresponding to the domain; and generating a reservoir simulation corresponding to the grid based on processing each domain. The domains can be processed in parallel on different computer systems, different processors, or different cores.

Abstract: Systems, computer-readable media, and methods for performing a reservoir simulation by obtaining reservoir data; translating the reservoir data into grid properties to create a grid; dividing the grid into domains; generating coarse grids corresponding to each domain; processing the domains, where processing a domain includes: calculating pressure for the domain using a coarse grid corresponding to the domain, calculating flux for the domain using a coarse grid corresponding to the domain, and calculating transport of fluids for the domain using a coarse grid corresponding to the domain; and generating a reservoir simulation corresponding to the grid based on processing each domain. The domains can be processed in parallel on different computer systems, different processors, or different cores.

Abstract: The present invention provides a system that comprises a memory and a queue manager that maintains a virtual queue in the memory for a consumable event, the virtual queue defining a current order of a plurality of agents, and summons one or more agents of the plurality of agents to the consumable event, wherein the queue manager is configured to communicate with a plurality of mobile devices, each mobile device of the plurality of mobile devices associated with an agent of the plurality of agents, wherein the queue manager communicates with each mobile device in order to monitor the associated agent, and wherein the queue manager is configured to dynamically determine when to summon one or more agents of the plurality of agents in the virtual queue to the consumable event based on the monitoring of the plurality of agents.

Abstract: A method for raycasting based on an irregular grid. The method includes raycasting, in a static mode, rays based on the irregular grid to generate a static image of a three dimensional (3D) volume dataset. The 3D volume dataset includes irregular grid cells based on the irregular grid. The method further includes reducing a tally of the rays to generate a reduced tally of rays based on a rendering time of the static image and an animation frame rate, and generating, in a dynamic mode, an animation of the 3D volume dataset at the animation frame rate by at least performing raycasting based on the reduced tally of rays.

Abstract: A method for reducing an order of a discrete fractured network simulation. The method includes receiving cells representing a portion of a subterranean formation that includes a fracture. A first plurality of the cells that correspond to the fracture may be marked as a first cell level. A second plurality of the cells that touch the first plurality of cells may be marked as a second cell level. The first plurality of cells may be grouped into a first superelement. The second plurality of cells may be grouped into a second superelement. One of the first plurality of cells in the first superelement may be designated as a master cell. A volume for the master cell may be updated to include volumes for each of the first plurality of cells in the first superelement.

Abstract: A method, apparatus, and program product use graph partitioning to distribute wells to a plurality of solve processors in a parallel reservoir simulation environment to optimize performance of well solve operations during reservoir simulations. Wells may be distributed to assign wells to partitions and associated solve processors and/or other processing resources in a manner that optimizes communication costs and/or costs associated with performing well solve operations.

Abstract: A method, apparatus, and program product utilize a generalized grid cell pinchout operation to remove small cells from a reservoir simulation grid, e.g., prior to running a reservoir simulation. The generalized grid cell pinchout operation may utilize a connectivity matrix representing transmissibilities of one or more “pinch” cells to be removed as well as that of “background” cells that neighbor the pinch cells. Removal of the pinch cells includes determining a Schur complement of the connectivity matrix to generate a reduced connectivity matrix from the connectivity matrix.

Abstract: A method for raycasting based on an irregular grid. The method includes raycasting, in a static mode, rays based on the irregular grid to generate a static image of a three dimensional (3D) volume dataset. The 3D volume dataset includes irregular grid cells based on the irregular grid. The method further includes reducing a tally of the rays to generate a reduced tally of rays based on a rendering time of the static image and an animation frame rate, and generating, in a dynamic mode, an animation of the 3D volume dataset at the animation frame rate by at least performing raycasting based on the reduced tally of rays.

Abstract: A method, system, and computer-readable medium for providing a visualization of a model. The method includes receiving a grid of the model including cells representing space, time, or both in the model. The method also includes grouping at least some of the cells into first-level gridlets. The method also includes grouping at least some of the first-level gridlets into second-level gridlets. The method further includes determining a first upper limit of elements to send for display, based on a display system capability, and determining that the number of first-level gridlets exceeds the first upper limit, and that the number of second-level gridlets is less than or equal to the first upper limit. In response, the method includes selecting at least some of the second-level gridlets for display and omitting from display at least some of the cells and at least some of the first-level gridlets.

Abstract: A method, apparatus, and program product use graph partitioning to distribute wells to a plurality of solve processors in a parallel reservoir simulation environment to optimize performance of well solve operations during reservoir simulations. Wells may be distributed to assign wells to partitions and associated solve processors and/or other processing resources in a manner that optimizes communication costs and/or costs associated with performing well solve operations.

Abstract: A method for reducing an order of a discrete fractured network simulation. The method includes receiving cells representing a portion of a subterranean formation that includes a fracture. A first plurality of the cells that correspond to the fracture may be marked as a first cell level. A second plurality of the cells that touch the first plurality of cells may be marked as a second cell level. The first plurality of cells may be grouped into a first superelement. The second plurality of cells may be grouped into a second superelement. One of the first plurality of cells in the first superelement may be designated as a master cell. A volume for the master cell may be updated to include volumes for each of the first plurality of cells in the first superelement.

Abstract: A method, apparatus, and program product utilize a generalized grid cell pinchout operation to remove small cells from a reservoir simulation grid, e.g., prior to running a reservoir simulation. The generalized grid cell pinchout operation may utilize a connectivity matrix representing transmissibilities of one or more “pinch” cells to be removed as well as that of “background” cells that neighbor the pinch cells. Removal of the pinch cells includes determining a Schur complement of the connectivity matrix to generate a reduced connectivity matrix from the connectivity matrix.

Abstract: A method, system, and computer-readable medium for providing a visualization of a model. The method includes receiving a grid of the model including cells representing space, time, or both in the model. The method also includes grouping at least some of the cells into first-level gridlets. The method also includes grouping at least some of the first-level gridlets into second-level gridlets. The method further includes determining a first upper limit of elements to send for display, based on a display system capability, and determining that the number of first-level gridlets exceeds the first upper limit, and that the number of second-level gridlets is less than or equal to the first upper limit. In response, the method includes selecting at least some of the second-level gridlets for display and omitting from display at least some of the cells and at least some of the first-level gridlets.

Abstract: A method can include providing a system of equations with associated variables that describe physical phenomena associated with a geologic formation; decoupling the system of equations to provide a system of pressure equations with associated pressure variables; solving the system of pressure equations for values of the pressure variables; and, based at least in part on the values of the pressure variables, solving the system of equations for values of the associated variables where the solving the system of equations includes applying a block approximate inverse preconditioner technique to at least blocks of mass conservation terms of the system of equations. Various other apparatuses, systems, methods, etc., are also disclosed.

Abstract: Electrospun polymer fibres comprising an amorphous calcium compound, oral care compositions comprising such fibres and their use in remineralising dental hard tissues and/or blocking dentinal tubules are described. Such compositions are of use in strengthening dental enamel of teeth thereby providing protection from acidic challenges. Such compositions are of use in combating dental erosion and/or tooth wear. Such compositions are of use in combating dental caries. Such compositions are of use in combating dentine hypersensitivity.

Abstract: The present invention provides a new metal or metal oxide porous material and a preparation method thereof, and more particularly concerns a new sponge-shaped noble metal, especially a silver porous material that is useful as a catalyst for an organic synthetic reaction such as an epoxidation reaction and partial oxidation reaction, and a functional material for electronic devices, heat dissipation and bacterial filtration and a preparation method thereof, as well as such a new silver catalyst.