Abstract: The disclosure relates to methods for the treatment of, or for reducing the risk for development of, a cardiometabolic in a patient using an inhibitor of type I IFN signalling.

Abstract: A patient transport apparatus (100, 10) which is configurable in at least three modes of operation, according to specific operational requirements. The apparatus (100, 10) comprises a patient support assembly 12 and at least a first and second wheel arrangement (14, 16). The patient support assembly 12 comprises a main portion 12.1, and a first and second portion (12.2, 12.3) extending from opposite sides of the main portion 12.1. The first and second portions (12.2, 12.3) are independently adjustable relative to the main portion 12.1. The first and second wheel arrangements (14, 16) are independently adjustable relative to the patient support assembly 12. The patient transport apparatus (100, 10) is configurable as a stretcher, as a chair (or wheelchair) and as a stair chair, by relative adjustment of the patient support assembly 12 and the first and second wheel arrangements (14, 16).

Abstract: According to the invention the pet caddy has a substantially flat bottom, a soft side wall extending from the bottom to an open top encircled with a rim structure to maintain an opening at the toe, with two integral brackets adjacent to the top arranged to clamp around the bicycle handlebars to support the caddy with a removable strut secured to the bottom and extending to neck of the handle bars to support the caddy in a vertical position, plus a strap located on the inside surface of the wall for connecting a short leash to restrain a pet while in the caddy. Handles are connected to the wall so that the caddy can be carried like a satchel without removing a pet. Removable padding inserted on the bottom enclosure of the housing creates a more comfortable environment for the pet and can be removed and replaced if soiled. The base of wall also has a plurality of ventilation ports for air circulation.