Patents by Inventor Dominic Zichi

Dominic Zichi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for the automated generation of nucleic acid ligands
    Patent number: 6569620
    Abstract: The present invention includes a method and device for performing automated SELEX. The steps of the SELEX process are performed at one or more work stations on a work surface by a cartesian robotic manipulator controlled by a computer.
    Type: Grant
    Filed: January 19, 1999
    Date of Patent: May 27, 2003
    Assignee: SomaLogic, Inc.
    Inventors: Larry Gold, Dominic A. Zichi, Robert D. Jenison, Daniel J. Schneider
  • Nucleic acid ligand diagnostic biochip
    Patent number: 6544776
    Abstract: A diagnostic biochip comprising a solid support to which one or more specific nucleic acid ligands is attached in a spatially defined manner is provided. Each nucleic acid ligand binds specifically and avidly to a particular target molecule contained within a test mixture, such as a bodily fluid. Also provided are methods for the preparation of nucleic acid ligand biochips. Further, methods for the use of the nucleic acid ligand biochip in diagnosis of a medical condition and quantitative detection of a target molecule are provided.
    Type: Grant
    Filed: August 14, 2000
    Date of Patent: April 8, 2003
    Assignee: Somalogic, Inc.
    Inventors: Larry Gold, Daniel Drolet, Dominic A. Zichi, Sumedha Jayasena, Steve Creighton, Stanley Gill
  • Method and apparatus for the automated generation of nucleic acid ligands
    Publication number: 20030054360
    Abstract: The present invention includes a method and device for performing the automated SELEX process, including automated photoSELEX process embodiments, and automated affinity SELEX process embodiments. The automated photoSELEX embodiments included an embodiment wherein target protein and nucleic acid ligands are photocrosslinked in solution. The steps of the SELEX process are performed at one or more work stations on a work surface by a robotic manipulator controlled by a computer.
    Type: Application
    Filed: November 21, 2001
    Publication date: March 20, 2003
    Inventors: Larry Gold, Dominic A. Zichi, Jonathan Drew Smith, Daniel J. Schneider
  • Modified SELEX processes without purified protein
    Publication number: 20030044818
    Abstract: This invention is directed towards a method for obtaining nucleic acid ligands against target proteins without directly purifying the target proteins. The method used in the invention is called SELEX, which is an acronym for Systematic Evolution of Ligands by EXponential enrichment. The nucleic acid ligands of the invention are useful as diagnostic and therapeutic agents for diseases in which the targets proteins play a causative role.
    Type: Application
    Filed: March 12, 2002
    Publication date: March 6, 2003
    Inventors: Larry Gold, Dominic A. Zichi, Jonathan Drew Smith
  • Method and apparatus for the automated generation of nucleic acid ligands
    Publication number: 20020064780
    Abstract: The present invention includes a method and device for performing automated SELEX. The steps of the SELEX process are performed at one or more work stations on a work surface by a robotic manipulator controlled by a computer. The invention also includes methods and reagents to obviate the need for size-fractionation of amplified candidate nucleic acids before beginning the next round of the SELEX process.
    Type: Application
    Filed: March 22, 2001
    Publication date: May 30, 2002
    Inventors: Larry Gold, Dominic A. Zichi, Robert D. Jenison, Daniel J. Schneider
  • Modified SELEX processes without purified protein
    Patent number: 6376190
    Abstract: This invention is directed towards a method for obtaining nucleic acid ligands against target proteins without directly purifying the target proteins. The method used in the invention is called SELEX, which is an acronym for Systematic Evolution of Ligands by EXponential enrichment. The nucleic acid ligands of the invention are useful as diagnostic and therapeutic agents for diseases in which the targets proteins play a causative role.
    Type: Grant
    Filed: September 22, 2000
    Date of Patent: April 23, 2002
    Assignee: SomaLogic, Inc.
    Inventors: Larry Gold, Dominic A. Zichi, Jonathan Drew Smith
  • Method and apparatus for determining consensus secondary structures for nucleic acid sequences
    Patent number: 5843732
    Abstract: An interactive computer program generates a composite dot matrix representation of secondary structure elements from a set of functionally related oligonucleotides. The composite image facilitates visual detection of conserved secondary structure motifs with similar sequence sets. The complete pattern displaying all possible base pairings can be readily pruned with two progressive filters to provide the user with a simplified figure displaying only the most stable and conserved regions. Additional simplification of the structure matrix image can be achieved by eliminating mutually exclusive structures. Alignment editing provided within the program facilitates refinement of the consensus secondary structure.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: December 1, 1998
    Assignee: NeXstar Pharmaceuticals, Inc.
    Inventors: Jeffrey P. Davis, Nebojsa Janjic, Dominic A. Zichi