Patents by Inventor Dominick F. Gratale

Dominick F. Gratale has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Arylthiazolidinedione derivitives
    Patent number: 6200998
    Abstract: Substituted 5-aryl-2,4-thiazolidinediones are potent agonists of PPAR, and are therefore useful in the treatment, control or prevention of diabetes, hyperglycemia, hyperlipidemia (including hypercholesterolemia and hypertriglyceridemia), atherosclerosis, obesity, vascular restenosis, and other PPAR &agr;, &dgr; and/or &ggr; mediated diseases, disorders and conditions.
    Type: Grant
    Filed: November 23, 1999
    Date of Patent: March 13, 2001
    Assignee: Merck & Co., Inc.
    Inventors: Soumya P. Sahoo, Wei Han, Richard L. Tolman, Jeffrey Bergman, Conrad Santini, Ranjit Desai, Victoria K. Lombardo, Julia K. Boueres, Dominick F. Gratale
  • Process for the stereoselective synthesis of 16-substituted-4-aza-androstanones
    Patent number: 6143887
    Abstract: The novel process of the present invention involves the stereoselective synthesis of certain 16.beta.-substituted 4-aza-5.alpha.-androstan-3-ones and the useful intermediates obtained therein.
    Type: Grant
    Filed: May 11, 1999
    Date of Patent: November 7, 2000
    Assignee: Merck & Co., Inc.
    Inventors: Dominick F. Gratale, Richard L. Tolman, Soumya P. Sahoo
  • Arylthiazolidinedione derivatives
    Patent number: 6008237
    Abstract: Substituted 5-aryl-2,4-thiazolidinediones are potent agonists of PPAR, and are therefore useful in the treatment, control or prevention of diabetes, hyperglycemia, hyperlipidemia (including hypercholesterolemia and hypertriglyceridemia), atherosclerosis, obesity, vascular restenosis, and other PPAR .alpha., .delta. and/or .gamma. mediated diseases, disorders and conditions.
    Type: Grant
    Filed: December 17, 1998
    Date of Patent: December 28, 1999
    Assignee: Merck & Co., Inc.
    Inventors: Soumya P. Sahoo, Richard L. Tolman, Wei Han, Jeffrey Bergman, Conrad Santini, Victoria K. Lombardo, Ranjit Desai, Julia K. Boueres, Dominick F. Gratale