Patents by Inventor Dominik Escher

Dominik Escher has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Immunoglobulin frameworks which demonstrate enhanced stability in the intracellular environment and methods of identifying same
    Patent number: 8853362
    Abstract: Compositions are provided, which can be used as frameworks for the creation of very stable and soluble single-chain Fv antibody fragments. These frameworks have been selected for intracellular performance and are thus ideally suited for the creation of scFv antibody fragments or scFv antibody libraries for applications where stability and solubility are limiting factors for the performance of antibody fragments, such as in the reducing environment of a cell. Such frameworks can also be used to identify highly conserved residues and consensus sequences which demonstrate enhanced solubility and stability.
    Type: Grant
    Filed: May 21, 2003
    Date of Patent: October 7, 2014
    Assignee: ESBATech, an Alcon Biomedical Research Unit LLC
    Inventors: Kathrin Tissot, Stefan Ewert, Adrian Auf Der Maur, Alcide Barberis, Dominik Escher
  • Acceptor framework for CDR grafting
    Patent number: 8399625
    Abstract: The present invention relates to an antibody acceptor framework and to methods for grafting non-human antibodies, e.g., rabbit antibodies, using a particularly well suited antibody acceptor framework. Antibodies generated by the methods of the invention are useful in a variety of diagnostic and therapeutic applications.
    Type: Grant
    Filed: June 25, 2010
    Date of Patent: March 19, 2013
    Assignee: ESBATech, an Alcon Biomedical Research Unit, LLC
    Inventor: Dominik Escher
  • Acceptor framework for CDR grafting
    Patent number: 8399624
    Abstract: The present invention relates to an antibody acceptor framework and to methods for grafting non-human antibodies, e.g., rabbit antibodies, using a particularly well suited antibody acceptor framework. Antibodies generated by the methods of the invention are useful in a variety of diagnostic and therapeutic applications.
    Type: Grant
    Filed: June 25, 2010
    Date of Patent: March 19, 2013
    Assignee: ESBATech, an Alcon Biomedical Research Unit LLC
    Inventor: Dominik Escher
  • Intrabodies with defined framework that is stable in a reducing environment and applications thereof
    Publication number: 20080233110
    Abstract: A method for the isolation of CDRs in a defined framework that is stable and soluble in reducing environment is described as well as thus obtainable scFv. Starting from such scFv with defined framework a scFv library can be generated wherein the framework is conserved while at least one complementary determining region (CDR) is randomized. Such library, e.g. in yeast cells, is suitable for screening for antibody/CDR-interactions or for screening for antibodies.
    Type: Application
    Filed: August 20, 2007
    Publication date: September 25, 2008
    Applicant: ESBATECH AG
    Inventors: Adrian Auf Der Maur, Alcide Barberis, Dominik Escher
  • Intrabodies with defined framework that is stable in a reducing environment and applications thereof
    Patent number: 7258985
    Abstract: A method for the isolation of CDRs in a defined framework that is stable and soluble in reducing environment is described as well as thus obtainable scFv. Starting from such scFv with defined framework a scFv library can be generated wherein the framework is conserved while at least one complementary determining region (CDR) is randomized. Such library, e.g. in yeast cells, is suitable for screening for antibody/CDR-interactions or for screening for antibodies.
    Type: Grant
    Filed: December 28, 2000
    Date of Patent: August 21, 2007
    Assignee: Esbatech AG
    Inventors: Adrian Auf Der Maur, Alcide Barberis, Dominik Escher
  • Intrabodies with defined framework that is stable in a reducing environment and applications thereof
    Patent number: 7258986
    Abstract: A method for the isolation of CDRs in a defined framework that is stable and soluble in reducing environment is described as well as thus obtainable scFv. Starting from such scFv with defined framework a scFv library can be generated wherein the framework is conserved while at least one complementary determining region (CDR) is randomized. Such library, e.g. in yeast cells, is suitable for screening for antibody/CDR-interactions or for screening for antibodies.
    Type: Grant
    Filed: December 18, 2000
    Date of Patent: August 21, 2007
    Assignee: ESBATech AG
    Inventors: Adrian Auf Der Maur, Alcide Barberis, Dominik Escher
  • Screening system
    Patent number: 6821728
    Abstract: The present invention concerns a screening system for screening effector peptides that can act as agonists or antagonists, as well as means to produce such a screening system, in particular a specific DNA library encoding peptides. In order to perform the screening, host cells comprising a selection system are transformed with the DNA library and the thus obtained screening system is then cultivated under conditions selectively allowing survival of cells with desired interaction.
    Type: Grant
    Filed: March 9, 2001
    Date of Patent: November 23, 2004
    Assignee: ESBATech AG
    Inventors: Dominik Escher, Alcide Barberis
  • Intrabodies with defined framework that is stable in a reducing environment and applications thereof
    Publication number: 20030096306
    Abstract: A method for the isolation of CDRs in a defined framework that is stable and soluble in reducing environment is described as well as thus obtainable scFv. Starting from such scFv with defined framework a scFv library can be generated wherein the framework is conserved while at least one complementary determining region (CDR) is randomized. Such library, e.g. in yeast cells, is suitable for screening for antibody/CDR-interactions or for screening for antibodies.
    Type: Application
    Filed: September 24, 2002
    Publication date: May 22, 2003
    Inventors: Adrian Auf Der Maur, Alcide Barberis, Dominik Escher
  • Intrabodies with defined framework that is stable in a reducing environment and applications thereof
    Publication number: 20010024831
    Abstract: A method for the isolation of CDRs in a defined framework that is stable and soluble in reducing environment is described as well as thus obtainable scFv. Starting from such scFv with defined framework a scFv library can be generated wherein the framework is conserved while at least one complementary determining region (CDR) is randomized. Such library, e.g. in yeast cells, is suitable for screening for antibody/CDR-interactions or for screening for antibodies.
    Type: Application
    Filed: December 28, 2000
    Publication date: September 27, 2001
    Inventors: Adrian Auf Der Maur, Alcide Barberis, Dominik Escher