Patents by Inventor Dominik GRIMM

Dominik GRIMM has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and compositions to detect mutations in plasma using exosomal RNA and cell free DNA from non-small cell lung cancer patients
    Patent number: 11427864
    Abstract: The present invention relates generally to methods and kits for detecting one or more biomarkers, such as an Epidermal Growth Factor Receptor (EGFR) mutation, e.g., T790M mutation, L858R mutation, one or more exon19 insertions and/or one or more exon19 deletions in the EGFR gene, in a biological sample to aid in diagnosis, prognosis, monitoring, or therapy selection for a disease such as, for example, cancer. The methods and kits are useful in aiding in diagnosis, prognosis, monitoring, or therapy selection for lung cancer, e.g., non-small cell lung cancer (NSCLC).
    Type: Grant
    Filed: November 17, 2017
    Date of Patent: August 30, 2022
    Assignee: Exosome Diagnostics, Inc.
    Inventors: Johan Karl Olov Skog, Elena Castellanos-Rizaldos, Vasisht Tadigotla, Dominik Grimm, Xuan Zhang, Wei Yu
  • Sequencing and analysis of exosome associated nucleic acids
    Patent number: 11396676
    Abstract: The invention provides a series of steps that prepare nucleic acids (RNA and/or DNA) isolated from extracellular vesicles for sequencing. This enables a wide diversity of RNAs and/or DNAs, to be efficiently detected. These can then be used to identify various attributes such as gene expression, alternative splicing, and the detection of both somatic and germline mutations including single nucleotide variants (SNV) and structural variations (insertions/deletions, fusions, inversions).
    Type: Grant
    Filed: October 23, 2017
    Date of Patent: July 26, 2022
    Assignee: Exosome Diagnostics, Inc.
    Inventors: Johan Skog, Sudipto Chakrabortty, Dalin Chan, Michael Valentino, Vasisht Tadigotla, Robert Kitchen, Dominik Grimm, Wei Yu
  • SEQUENCING AND ANALYSIS OF EXOSOME ASSOCIATED NUCLEIC ACIDS
    Publication number: 20200208213
    Abstract: The invention provides a series of steps that prepare nucleic acids (RNA and/or DNA) isolated from extracellular vesicles for sequencing. This enables a wide diversity of RNAs and/or DNAs, to be efficiently detected. These can then be used to identify various attributes such as gene expression, alternative splicing, and the detection of both somatic and germline mutations including single nucleotide variants (SNV) and structural variations (insertions/deletions, fusions, inversions).
    Type: Application
    Filed: October 23, 2017
    Publication date: July 2, 2020
    Inventors: Johan SKOG, Sudipto CHAKRABORTTY, Dalin CHAN, Michael VALENTINO, Vasisht TADIGOTLA, Robert KITCHEN, Dominik GRIMM, Wei YU
  • METHODS AND COMPOSITIONS TO DETECT MUTATIONS IN PLASMA USING EXOSOMAL RNA AND CELL FREE DNA FROM NON-SMALL CELL LUNG CANCER PATIENTS
    Publication number: 20190376128
    Abstract: The present invention relates generally to methods and kits for detecting one or more biomarkers, such as an Epidermal Growth Factor Receptor (EGFR) mutation, e.g., T790M mutation, L858R mutation, one or more exon19 insertions and/or one or more exon19 deletions in the EGFR gene, in a biological sample to aid in diagnosis, prognosis, monitoring, or therapy selection for a disease such as, for example, cancer. The methods and kits are useful in aiding in diagnosis, prognosis, monitoring, or therapy selection for lung cancer, e.g., non-small cell lung cancer (NSCLC).
    Type: Application
    Filed: November 17, 2017
    Publication date: December 12, 2019
    Inventors: Johan Karl Olov SKOG, Elena CASTELLANOS-RIZALDOS, Vasisht TADIGOTLA, Dominik GRIMM, Xuan ZHANG, Wei YU