Abstract: The present invention concerns antigen binding proteins specifically binding melanoma associated antigen A (MAGE-A) protein-derived antigens. The invention in particular provides antigen binding proteins which specifically bind to the MAGE-A antigenic peptide comprising or consisting of SEQ ID NO: 1 in a complex with a major histocombatibility (MHC) protein. The antigen binding proteins of the invention contain, in particular, the complementary determining regions (CDRs) of novel engineered T cell receptors (TCRs) that specifically bind to said MAGE-A peptide/MHC complex. The antigen binding proteins of the invention are of use for the diagnosis, treatment and prevention of MAGE-A expressing cancerous diseases. Further provided are nucleic acids encoding the antigen binding proteins of the invention, vectors comprising these nucleic acids, recombinant cells expressing the antigen binding proteins and pharmaceutical compositions comprising the antigen binding proteins of the invention.

Abstract: The present invention concerns antigen binding proteins directed against PRAME protein-derived antigens. The invention in particular provides antigen binding proteins which are specific for the tumor expressed antigen PRAME, wherein the tumor antigen comprises or consists of SEQ ID NO: 50 and is in a complex with a major histocompatibility complex (MHC) protein. The antigen binding proteins of the invention contain, in particular, the complementary determining regions (CDRs) of novel engineered T cell receptors (TCRs) that specifically bind to said PRAME peptide. The antigen binding proteins of the invention are for use in the diagnosis, treatment and prevention of PRAME expressing cancerous diseases. Further provided are nucleic acids encoding the antigen binding proteins of the invention, vectors comprising said nucleic acids, recombinant cells expressing the antigen binding proteins and pharmaceutical compositions comprising the antigen binding proteins of the invention.

Abstract: The present invention pertains to antigen recognizing constructs against COL6A3 antigens. The invention in particular provides novel engineered T cell receptor (TCR) based molecules which are selective and specific for the tumor expressing antigen COL6A3. The TCR of the invention, and COL6A3 antigen binding fragments derived therefrom, are of use for the diagnosis, treatment and prevention of COL6A3 expressing cancerous diseases. Further provided are nucleic acids encoding the antigen recognizing constructs of the invention, vectors comprising these nucleic acids, recombinant cells expressing the antigen recognizing constructs and pharmaceutical compositions comprising the compounds of the invention.

Abstract: A module assembly for a vehicle, including a shell construction, defining a window opening, and a module component fixed to the shell construction and forming a part of the sill flange extending along a longitudinal extension direction for attaching a seal in a sill region of the window opening, wherein at least one flange section of the shell construction extending along the longitudinal extension direction and/or at least one flange section of the module component extending along the longitudinal extension direction is provided for forming the sill flange. The flange section of the shell construction and/or the flange section of the module component has at least one contact region protruding transverse to the longitudinal extension direction.

Abstract: A vehicle door assembly, having a first frame component including a window frame for a window opening and two opposing lateral frame for defining a frame cut-out and forming a sill portion connecting the two lateral frame portions to one another, a second frame component for strengthening the window frame, the second frame component fixed on the first frame component, and a door module carrier formed from an organosheet and at least partially closes the frame cut-out. The door module carrier forming an edge portion fixed to the sill portion in a longitudinal direction of the sill portion. The organosheet is a supporting structural component and an edge portion thereof is reinforced by a reinforcing structure injection-moulded onto the organosheet and the edge portion thereof strengthens the sill portion of the first frame component where no portion of the second frame component is provided.

Abstract: A carrier assembly for a vehicle, comprising a carrier component. A fastening point for fastening the carrier component is provided at a fastening area of the carrier component made of a fiber composite material, which specifies a position for a through-opening yet to be formed by the attachment of a fastening element along a direction of attachment and which forms at least one support element protruding along the direction of attachment, against which a head portion of the fastening element rests at least in a non-positive manner when a fastening portion of the fastening element properly extends through the material of the carrier component.

Abstract: A vehicle door assembly, having a first frame component including a window frame for a window opening and two opposing lateral frame for defining a frame cut-out and forming a sill portion connecting the two lateral frame portions to one another, a second frame component for strengthening the window frame, the second frame component fixed on the first frame component, and a door module carrier formed from an organosheet and at least partially closes the frame cut-out. The door module carrier forming an edge portion fixed to the sill portion in a longitudinal direction of the sill portion. The organosheet is a supporting structural component and an edge portion thereof is reinforced by a reinforcing structure injection-moulded onto the organosheet and the edge portion thereof strengthens the sill portion of the first frame component where no portion of the second frame component is provided.

Abstract: A method and system for capturing, sharing, viewing, and/or displaying one or more videos. A user of a computing device performs a gesture involving contacting a touch sensitive display. In response, a video segment is captured while the user maintains contact with the touch sensitive display. Upon releasing contact with the touch sensitive display, recording of the video segment is ceased. In one or more embodiments of the invention, the user may then record one or more additional video segments to be included in a video vignette.

Abstract: A door assembly and an assembly method for a door assembly with a door skin, a support component and an interior trim component, the support component is fastened to the door skin by at least one mounting component. The at least one mounting component is also used for mounting the interior trim component since a head section of the mounting component projects from the support component and the interior trim component is mounted on the head section.

Abstract: A method and system for capturing, sharing, viewing, and/or displaying one or more videos. A user of a computing device performs a gesture involving contacting a touch sensitive display. In response, a video segment is captured while the user maintains contact with the touch sensitive display. Upon releasing contact with the touch sensitive display, recording of the video segment is ceased. In one or more embodiments of the invention, the user may then record one or more additional video segments to be included in a video vignette.

Abstract: A module assembly for a vehicle, including a shell construction, defining a window opening, and a module component fixed to the shell construction and forming a part of the sill flange extending along a longitudinal extension direction for attaching a seal in a sill region of the window opening, wherein at least one flange section of the shell construction extending along the longitudinal extension direction and/or at least one flange section of the module component extending along the longitudinal extension direction is provided for forming the sill flange. The flange section of the shell construction and/or the flange section of the module component has at least one contact region protruding transverse to the longitudinal extension direction.

Abstract: A carrier assembly for a vehicle, comprising a carrier component. A fastening point for fastening the carrier component is provided at a fastening area of the carrier component made of a fiber composite material, which specifies a position for a through-opening yet to be formed by the attachment of a fastening element along a direction of attachment and which forms at least one support element protruding along the direction of attachment, against which a head portion of the fastening element rests at least in a non-positive manner when a fastening portion of the fastening element properly extends through the material of the carrier component.

Abstract: A method and system for capturing, sharing, viewing, and/or displaying one or more video videos. A user of a computing device performs a gesture involving contacting a touch sensitive display. In response, a video segment is captured while the user maintains contact with the touch sensitive display. Upon releasing contact with the touch sensitive display, recording of the video segment is ceased. In one or more embodiments of the invention, the user may then record one or more additional video segments to be included in a video vignette.

Abstract: A method and system for capturing, sharing, viewing, and/or displaying one or more video videos. A user of a computing device performs a gesture involving contacting a touch sensitive display. In response, a video segment is captured while the user maintains contact with the touch sensitive display. Upon releasing contact with the touch sensitive display, recording of the video segment is ceased. In one or more embodiments of the invention, the user may then record one or more additional video segments to be included in a video vignette.

Abstract: A traction-means tensioning device having a housing that contains aluminum as a material, into which a slide sleeve is inserted axially immovably, within which a hydraulically actuatable, axially extendable piston is supported; a pressure chamber being provided between the piston, which is made of steel, and the slide sleeve, which is made of steel, that can be filled with a hydraulic medium; a securing element engaging on the slide sleeve and the housing to fix the axial position of the slide sleeve relative to the housing, the securing element being provided with an elongate fastening portion that is configured to be fixed in position in the housing and is provided at a housing-distal end with a head that is in form-fitting contact with the slide sleeve. Also, an internal combustion engine having such a traction-means tensioning device and a traction means.

Abstract: A traction-means tensioning device having a housing that contains aluminum as a material, into which a slide sleeve is inserted axially immovably, within which a hydraulically actuatable, axially extendable piston is supported; a pressure chamber being provided between the piston, which is made of steel, and the slide sleeve, which is made of steel, that can be filled with a hydraulic medium; a securing element engaging on the slide sleeve and the housing to fix the axial position of the slide sleeve relative to the housing, the securing element being provided with an elongate fastening portion that is configured to be fixed in position in the housing and is provided at a housing-distal end with a head that is in form-fitting contact with the slide sleeve. Also, an internal combustion engine having such a traction-means tensioning device and a traction means.

Abstract: A chain tensioning device for use in a motor vehicle with a cylinder-piston unit (10) that has a piston housing (11) and a tensioning piston (12) that is provided for tensioning a chain and is arranged at least partially in the piston housing (11). A chain tensioner housing (13) is provided for establishing a flow connection between the cylinder-piston unit (10) and an operating medium circuit and holds at least partially the cylinder-piston unit (10). A compression joint fixes the piston housing (11) and the chain tensioner housing (13) against each other at least in the axial direction. The compression joint is constructed as a press fit by which the piston housing (11) and the chain tensioner housing (13) are directly connected to each other with a friction fit.

Abstract: A hydraulic tensioning system (1), which is used in traction mechanism drives, particularly chain drives of internal combustion engines, is provided. The tensioning system (1) includes a piston (3), which is designed in the shape of a crucible, subjected to a pressure by a pressure spring (8), guided in a linearly displaceable manner in a housing (2) and spring-loaded against a traction mechanism. Hydraulic fluid can flow out of a pressure chamber (5) depending on an actuating direction of the piston (3) via an overpressure valve (11) forming a damper and associated with the piston (3) or can enter via a one-way valve (7) of the housing (2) into the pressure chamber (5). The overpressure valve (11) encloses a valve plate (15) that is integrated in the piston (3), and a pressure spring (8) of the piston (3) surrounds an outside of the valve housing (12) of the overpressure valve (11).

Abstract: A hydraulic tensioning system (1), which is used in traction mechanism drives, particularly chain drives of internal combustion engines, is provided. The tensioning system (1) includes a piston (3), which is designed in the shape of a crucible, subjected to a pressure by a pressure spring (8), guided in a linearly displaceable manner in a housing (2) and spring-loaded against a traction mechanism. Hydraulic fluid can flow out of a pressure chamber (5) depending on an actuating direction of the piston (3) via an overpressure valve (11) forming a damping device (22) and associated with the piston (3) or can enter via a one-way valve (7) of the housing (2) into the pressure chamber (5). The overpressure valve (11) encloses a plate valve (21) that is integrated in the piston (3), and a pressure spring (8) of the piston (3) surrounds an outside of the valve housing (12) of the overpressure valve (11).

Abstract: A method and device for the application of an elongated electric conductor to a solar element wherein the required length of the elongated electric conductor is readied and the conductor is strained through application of a tensile stress. The conductor is then fastened to the solar element. Straining of the elongated electric conductor is monitored to prevent exceeding of a tensile limit. During fastening onto the solar element at least one press-on roller is employed.