Abstract: The invention generally refers to a cell-targeting nanoparticle, wherein the cell-targeting nanoparticle is directly conjugated to at least one cysteine-containing peptide, wherein the cysteine-containing peptide is selected from the group consisting of glutathione (GSM, a GSH-containing peptide, and a peptide comprising a nuclear localization signal (NLS) sequence and a transporter sequence, and methods of using the cell-targeting nanoparticle.

Abstract: The present invention relates to a method and polymer for improving stability of Layer-by-Layer (LbL) assemblies or films such as for antifouling performances in a sea water environment. Stability enhancement is achieved by an application of a custom made polyanion that can be easily crosslinked in a mild condition without any other chemical addition, or high energy radiation, to form covalent bond, with any polyamines.

Abstract: An amphiphilic polymer (A) comprising repeat units of the general formulae (I), (II) and (III): or salts thereof, wherein R1 is H or methyl, R2 is an aliphatic moiety with a main chain of 3 to 30 carbon atoms and 0 to 3 heteroatoms selected from the group N, O, S, Se and Si, and R3 is one of (i) an alicyclic moiety with a main chain of 5 to 80 carbon atoms and 0 to 30 heteroatoms (ii) a moiety —Z—R4 wherein R4 is an alicyclic moiety with a main chain of 5 to 80 carbon atoms and 0 to 30 heteroatoms and Z is an aliphatic bridge of 1 to 3 carbon atoms and 0 to 2 heteroatoms, (iii) an aliphatic moiety with a main chain of 3 to 80 carbon atoms and 0 to about 30, and a C?C group or an azido group.

Abstract: The invention generally refers to a cell-targeting nanoparticle, wherein the cell-targeting nanoparticle is directly conjugated to at least one cysteine-containing peptide, wherein the cysteine-containing peptide is selected from the group consisting of glutathione (GSM, a GSH-containing peptide, and a peptide comprising a nuclear localization signal (NLS) sequence and a transporter sequence, and methods of using the cell-targeting nanoparticle.

Abstract: The invention relates to an amphiphilic polymer (A) comprising repeat units of the general formulae (I), (II) and (III): or salts thereof, wherein the repeat unit of general formula (I) is comprised in the amphiphilic polymer with a number of m units, the repeat unit of general formula (II) is comprised in the amphiphilic polymer with a number of o units and repeat unit of general formula (III) is comprised in the amphiphilic polymer with a number of p units, wherein each of m, o and p is an independently selected integer from about 3 to about 400 and wherein the sum of m+o+p is selected in the range from about 10 to about 10000, R1 in repeat units (I)-(III) is H or methyl, R2 in repeat unit (II) is an aliphatic moiety with a main chain of about 3 to about 30 carbon atoms and 0 to about 3 heteroatoms selected from the group N, O, S, Se and Si, and, R3 in repeat unit (III) is one of (i) an alicyclic moiety with a main chain of about 5 to about 80 carbon atoms and 0 to about 30 heteroatoms selected from the gro

Abstract: Disclosed are an amphiphilic polymer, its synthesis and uses thereof. The polymer has a hydrocarbon backbone with —COOH side groups. It further has first aliphatic moieties with a main chain of about 3 to about 20 carbon atoms and 0 to about 3 heteroatoms, and second aliphatic moieties that have a main chain of about 3 to about 80 carbon atoms and about 2 to about 40 heteroatoms. The second aliphatic moieties have a copolymerisable group. In the synthesis a maleic anhydride polymer of formula (I) where n is an integer from about 10 to about 10000 and R1 is H or methyl, is reacted with a monofunctional compound with an alkyl chain of about 3 to about 20 carbon atoms and 0 to about 2 heteroatoms, and with an at least bifunctional compound with an alkyl chain of about 3 to about 80 carbon atoms and 0 to about 40 heteroatoms. The functional group of the monofunctional compound and one functional group of the at least bifunctional compound can form a linkage with an anhydride.