Patents by Inventor Dominik PAQUET

Dominik PAQUET has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Enhancement of CRISPR gene editing or target destruction by co-expression of heterologous DNA repair protein
    Patent number: 11453874
    Abstract: Provided are compositions, methods, and kits for improving CRISPR-based editing of DNA targets by a CRISPR-associated (Cas) enzyme. The improvement is made by combining the Cas enzyme and a CRISPR targeting RNA a heterologous DNA repair enzyme that is at least one of RecBCD, AddAB, or AdnAB. The heterologous DNA repair enzyme may have inactivated nuclease activity. The method can include using a DNA repair template to introduce one or more changes into the edited DNA. Cells that contain components of the improved CRISPR systems are included, as are kits for making such cells.
    Type: Grant
    Filed: June 6, 2018
    Date of Patent: September 27, 2022
    Assignee: The Rockefeller University
    Inventors: Luciano Marraffini, Jon McGinn, Josh Modell, Dominik Paquet
  • ENHANCEMENT OF CRISPR GENE EDITING OR TARGET DESTRUCTION BY CO-EXPRESSION OF HETEROLOGOUS DNA REPAIR PROTEIN
    Publication number: 20200140847
    Abstract: Provided are compositions, methods, and kits for improving CRISPR-based editing of DNA targets by a CRISPR-associated (Cas) enzyme. The improvement is made by combining the Cas enzyme and a CRISPR targeting RNA a heterologous DNA repair enzyme that is at least one of RecBCD, AddAB, or AdnAB. The heterologous DNA repair enzyme may have inactivated nuclease activity. The method can include using a DNA repair template to introduce one or more changes into the edited DNA. Cells that contain components of the improved CRISPR systems are included, as are kits for making such cells.
    Type: Application
    Filed: June 6, 2018
    Publication date: May 7, 2020
    Inventors: Luciano MARRAFFINI, Jon MCGINN, Josh MODELL, Dominik PAQUET