Abstract: The present invention relates to an expression vector, an expression cassette or a pseudotyped viral vector particle comprising at least one nucleic acid encoding at least one Koala Retrovirus (KoRV) Envelope glycoprotein (Env), related nucleic acids, pseudotyped viral vector particles, mammalian packaging cell lines, transduced mammalian cells as well as related methods and uses.

Abstract: The present disclosure relates to a device for lubricating an internal combustion engine having a crankshaft, which is connected to at least one connecting rod. The device has at least one first flow limiter, in particular a restrictor, for reducing a lubricating fluid flow of a lubricating fluid stream passed to the at least one first flow limiter. The device has a plurality of crankshaft bearings for the rotatable support of the crankshaft, wherein the plurality of crankshaft bearings is provided in fluid communication downstream of the at least one first flow limiter. The device has at least one big end bearing for the rotatable support of the at least one connecting rod, wherein the at least one big end bearing is provided in fluid communication downstream of at least one crankshaft bearing of the plurality of crankshaft bearings.

Abstract: A device lubricates a connecting rod bearing on a crankshaft of an internal combustion engine. The device has a piston having an internal piston cooling fluid channel, and an outlet channel in fluid communication with the fluid channel. The device has a connecting rod, which is connected to the piston in an articulated, in particular pivotable, manner, and has a large connecting rod eye and a connecting channel. The large connecting rod eye is formed for receiving the connecting rod bearing. The connecting channel forms a fluid connection between the outlet channel and the large connecting rod eye so that a fluid, in particular a cooling lubricating fluid (e.g. oil), can be fed, or is fed, from the fluid channel to the large connecting rod eye via the outlet channel and the connecting channel. The connecting rod bearing can be lubricated by cooling oil from the fluid channel of the piston.

Abstract: A device lubricates a big-end bearing on a crankshaft of an internal combustion engine. The device includes a piston with a fluid channel and an outlet channel fluidically connected thereto, and a connecting rod. The connecting rod has a small connecting rod eye, a large connecting rod eye and a connecting channel. The small connecting rod eye is fluidically connected to the outlet channel. The connecting channel forms a fluidic connection between the small and large connecting rod eyes so that a cooling lubricant fluid can be supplied from the fluid channel to the large connecting rod eye via the outlet channel, the small connecting rod eye and the connecting channel. In this way, the big-end bearing can be lubricated by cooling oil from the fluid channel of the piston.

Abstract: An internal combustion engine for a vehicle is provided, having at least one cylinder with a first gas exchange inlet valve, a second gas exchange inlet valve, a first gas exchange outlet valve, a second gas exchange outlet valve, and a piston with a piston crown which has a plurality of valve seat pockets. In each case one valve seat pocket is provided for the first gas exchange inlet valve, the second gas exchange inlet valve, the first gas exchange outlet valve and the second gas exchange outlet valve, and the plurality of valve seat pockets have at least partially different depths. Alternatively, one valve seat pocket is provided for the first gas exchange inlet valve and the first gas exchange outlet valve, and no valve seat pocket is provided for the second gas exchange inlet valve and/or for the second gas exchange outlet valve.

Abstract: The present disclosure relates to a method for braking of an internal combustion engine, in particular a four-stroke internal combustion engine. The method involves a partial opening of at least one gas discharge valve of at least one cylinder of the internal combustion engine during a compression stroke of the internal combustion engine. The method involves a holding of a partial opening of the at least one gas discharge valve during an expansion stroke of the internal combustion engine following the compression stroke and during an exhaust stroke of the internal combustion engine following the expansion stroke. The method involves a closing of the partly opened at least one gas discharge valve at the end of the exhaust stroke or during an intake stroke of the internal combustion engine following the exhaust stroke.

Abstract: A piston for a reciprocating-piston internal combustion engine includes a piston head and a piston skirt. The piston head has an encircling ring zone having at least one ring groove for a piston ring and an encircling cooling duct. In this case, the piston further includes at least one first bore starting from the cooling duct, the bore leading from the cooling duct to a bearing location of an upper connecting-rod bearing pin of the piston and opening into the bearing location in the form of a bore opening in order to supply the piston pin with lubricant from the cooling duct.

Abstract: A device lubricates a connecting rod bearing on a crankshaft of an internal combustion engine. The device has a piston having an internal piston cooling fluid channel, and an outlet channel in fluid communication with the fluid channel. The device has a connecting rod, which is connected to the piston in an articulated, in particular pivotable, manner, and has a large connecting rod eye and a connecting channel. The large connecting rod eye is formed for receiving the connecting rod bearing. The connecting channel forms a fluid connection between the outlet channel and the large connecting rod eye so that a fluid, in particular a cooling lubricating fluid (e.g. oil), can be fed, or is fed, from the fluid channel to the large connecting rod eye via the outlet channel and the connecting channel. The connecting rod bearing can be lubricated by cooling oil from the fluid channel of the piston.

Abstract: A device lubricates a big-end bearing on a crankshaft of an internal combustion engine. The device includes a piston with a fluid channel and an outlet channel fluidically connected thereto, and a connecting rod. The connecting rod has a small connecting rod eye, a large connecting rod eye and a connecting channel. The small connecting rod eye is fluidically connected to the outlet channel. The connecting channel forms a fluidic connection between the small and large connecting rod eyes so that a cooling lubricant fluid can be supplied from the fluid channel to the large connecting rod eye via the outlet channel, the small connecting rod eye and the connecting channel. In this way, the big-end bearing can be lubricated by cooling oil from the fluid channel of the piston.

Abstract: An internal combustion engine for a vehicle is provided, having at least one cylinder with a first gas exchange inlet valve, a second gas exchange inlet valve, a first gas exchange outlet valve, a second gas exchange outlet valve, and a piston with a piston crown which has a plurality of valve seat pockets. In each case one valve seat pocket is provided for the first gas exchange inlet valve, the second gas exchange inlet valve, the first gas exchange outlet valve and the second gas exchange outlet valve, and the plurality of valve seat pockets have at least partially different depths. Alternatively, one valve seat pocket is provided for the first gas exchange inlet valve and the first gas exchange outlet valve, and no valve seat pocket is provided for the second gas exchange inlet valve and/or for the second gas exchange outlet valve.

Abstract: The present disclosure relates to a method for braking of an internal combustion engine, in particular a four-stroke internal combustion engine. The method involves a partial opening of at least one gas discharge valve of at least one cylinder of the internal combustion engine during a compression stroke of the internal combustion engine. The method involves a holding of a partial opening of the at least one gas discharge valve during an expansion stroke of the internal combustion engine following the compression stroke and during an exhaust stroke of the internal combustion engine following the expansion stroke. The method involves a closing of the partly opened at least one gas discharge valve at the end of the exhaust stroke or during an intake stroke of the internal combustion engine following the exhaust stroke.

Abstract: The present disclosure relates to a device for lubricating an internal combustion engine having a crankshaft, which is connected to at least one connecting rod. The device has at least one first flow limiter, in particular a restrictor, for reducing a lubricating fluid flow of a lubricating fluid stream passed to the at least one first flow limiter. The device has a plurality of crankshaft bearings for the rotatable support of the crankshaft, wherein the plurality of crankshaft bearings is provided in fluid communication downstream of the at least one first flow limiter. The device has at least one big end bearing for the rotatable support of the at least one connecting rod, wherein the at least one big end bearing is provided in fluid communication downstream of at least one crankshaft bearing of the plurality of crankshaft bearings.

Abstract: A drive device for a vehicle with and an exhaust gas tract connected to engine. The exhaust gas tract has a main line with an exhaust gas turbine of a turbocharger and a catalytic convertor downstream of the turbine. The exhaust gas tract has a bypass, by which at least some of the is conductible past a turbine wheel of the turbine such that the exhaust gas is conductible out of the main line at at least one a conducting-out region into the bypass line upstream of the turbine wheel. The bypass exhaust gas flow in the bypass line is conductible into the main line at downstream of the turbine wheel (41) and upstream of the catalytic convertor. To prevent overheating of the catalytic convertor, a cooling device is provided, by which the bypass exhaust gas flow flowing through the bypass line is coolable.

Abstract: An operating method for a device that has an internal combustion engine having a crankshaft and a plurality of cylinders and an exhaust gas aftertreatment system. The operating method is distinguished, in particular, by the fact that fuel injection into at least one of the cylinders is shut down when required and the at least one shut-down cylinder is put into a braking mode, with the result that the temperature of the exhaust gas for the exhaust gas aftertreatment system can be increased.

Abstract: An operating method for a device that has an internal combustion engine having a crankshaft and a plurality of cylinders and an exhaust gas aftertreatment system. The operating method is distinguished, in particular, by the fact that fuel injection into at least one of the cylinders is shut down when required and the at least one shut-down cylinder is put into a braking mode, with the result that the temperature of the exhaust gas for the exhaust gas aftertreatment system can be increased.