Abstract: The present invention concerns antigen binding proteins specifically binding melanoma associated antigen A (MAGE-A) protein-derived antigens. The invention in particular provides antigen binding proteins which specifically bind to the MAGE-A antigenic peptide comprising or consisting of SEQ ID NO: 1 in a complex with a major histocombatibility (MHC) protein. The antigen binding proteins of the invention contain, in particular, the complementary determining regions (CDRs) of novel engineered T cell receptors (TCRs) that specifically bind to said MAGE-A peptide/MHC complex. The antigen binding proteins of the invention are of use for the diagnosis, treatment and prevention of MAGE-A expressing cancerous diseases. Further provided are nucleic acids encoding the antigen binding proteins of the invention, vectors comprising these nucleic acids, recombinant cells expressing the antigen binding proteins and pharmaceutical compositions comprising the antigen binding proteins of the invention.

Abstract: The present invention concerns antigen binding proteins directed against PRAME protein-derived antigens. The invention in particular provides antigen binding proteins which are specific for the tumor expressed antigen PRAME, wherein the tumor antigen comprises or consists of SEQ ID NO: 50 and is in a complex with a major histocompatibility complex (MHC) protein. The antigen binding proteins of the invention contain, in particular, the complementary determining regions (CDRs) of novel engineered T cell receptors (TCRs) that specifically bind to said PRAME peptide. The antigen binding proteins of the invention are for use in the diagnosis, treatment and prevention of PRAME expressing cancerous diseases. Further provided are nucleic acids encoding the antigen binding proteins of the invention, vectors comprising said nucleic acids, recombinant cells expressing the antigen binding proteins and pharmaceutical compositions comprising the antigen binding proteins of the invention.

Abstract: A method for controlling a modular multilevel power converter which has at least one phase module branch with a series circuit of modules. Each of the modules has an energy storage device and a power semiconductor circuit with electronic switching elements. A duty cycle of the phase module branch is ascertained, wherein the duty cycle describes the ratio between the voltage which is being output by the phase module branch and the voltage which can be maximally output by the phase module branch. The maximum value of the duty cycle during a preselected time period is ascertained, and the maximum value of the duty cycle is controlled to a target value for the maximum value of the duty cycle by a controller.

Abstract: A converter has a plurality of partial converters, each partial converter having three-phase converter-side supply connections for parallel connection to the same electrical three-phase supply system and three-phase converter-side output connections with a star point for making contact with a star point of a three-phase output system. The converter-side output connections of the three-phase partial converters are connected in parallel. The partial converters each have a converter module for each partial converter-side three-phase supply connection, and the converter modules each have two or more submodules having their outputs connected in series, and a transformer.

Abstract: A converter has a plurality of partial converters, each partial converter having three-phase converter-side supply connections for parallel connection to the same electrical three-phase supply system and three-phase converter-side output connections with a star point for making contact with a star point of a three-phase output system. The converter-side output connections of the three-phase partial converters are connected in parallel. The partial converters each have a converter module for each partial converter-side three-phase supply connection, and the converter modules each have two or more submodules having their outputs connected in series, and a transformer.

Abstract: A method controls a power converter in which a target value of a control parameter is limited by at least one limiting value. The method is characterized in that the at least one limiting value is determined dynamically over time as a function of a power converter temperature. A power converter system having a control device is provided and configured to carry out the method.

Abstract: A method detects a working voltage collapse by use of an electric component, in which the exceeding of a critical characteristic of the working voltage is monitored and an excess is detected as a collapse. Accordingly, in order to recognize the collapse breakdown in a simple trouble-free manner, a model voltage generated by a model circuit is used as the critical characteristic.

Abstract: A sub-module of a modular braking unit that is connected to a DC transmission network. Each sub-module has an inverse diode, and a storage capacitor connected in parallel with the inverse diode via a free-wheeling diode. An energy-consuming switching unit is connected to the storage capacitor. In order to provide a sub-module of this type such that the braking unit can function with relatively low losses in the stand-by and idle state, the sub-module is provided with an actively switchable semiconductor bypass path in parallel with the inverse diode. A braking unit has a plurality of series-connected sub-modules and we disclose a method for operating a braking unit of this type.

Abstract: Energy transmission device for the wireless transmission of energy to an active implant, comprising: a transmitter coil adapted for electrical connection to an energy source, and an implantable receiver coil adapted for inductive coupling to the transmitter coil for wireless energy transmission, wherein an implantable primary coil is electrically connected to a modulator, the modulator modulating an AC voltage supplied to the implantable primary coil based on a data signal so that data transmission from the implantable primary coil to an extracorporeal secondary coil is performed, the frequency of the data transmission being different from the frequency at which the energy is transmitted from the transmitter coil to the receiver coil, and wherein information regarding the energy control of the energy to be transmitted from the transmitter coil is transmitted from the primary coil to the secondary coil by a pulse width modulated signal, other information not regarding the energy control is transmitted by means

Abstract: A sub-module of a modular braking unit that is connected to a DC transmission network. Each sub-module has an inverse diode, and a storage capacitor connected in parallel with the inverse diode via a free-wheeling diode. An energy-consuming switching unit is connected to the storage capacitor. In order to provide a sub-module of this type such that the braking unit can function with relatively low losses in the stand-by and idle state, the sub-module is provided with an actively switchable semiconductor bypass path in parallel with the inverse diode. A braking unit has a plurality of series-connected sub-modules and we disclose a method for operating a braking unit of this type.

Abstract: A method detects a working voltage collapse by use of an electric component, in which the exceeding of a critical characteristic of the working voltage is monitored and an excess is detected as a collapse. Accordingly, in order to recognize the collapse breakdown in a simple trouble-free manner, a model voltage generated by a model circuit is used as the critical characteristic.

Abstract: A converter for three-phase voltage has three electrically delta-connected series circuits. Each of the series circuits has at least two switching modules connected in series. A control device is connected to the switching modules and can drive the switching modules in such a way that branch currents with a fundamental frequency of the three-phase voltage and with at least one additional current harmonic flow in the series circuits. The additional current harmonic is dimensioned such that it flows in the series circuits of the converter and remains inside the converter.