Abstract: The present invention concerns antigen binding proteins specifically binding melanoma associated antigen A (MAGE-A) protein-derived antigens. The invention in particular provides antigen binding proteins which specifically bind to the MAGE-A antigenic peptide comprising or consisting of SEQ ID NO: 1 in a complex with a major histocombatibility (MHC) protein. The antigen binding proteins of the invention contain, in particular, the complementary determining regions (CDRs) of novel engineered T cell receptors (TCRs) that specifically bind to said MAGE-A peptide/MHC complex. The antigen binding proteins of the invention are of use for the diagnosis, treatment and prevention of MAGE-A expressing cancerous diseases. Further provided are nucleic acids encoding the antigen binding proteins of the invention, vectors comprising these nucleic acids, recombinant cells expressing the antigen binding proteins and pharmaceutical compositions comprising the antigen binding proteins of the invention.

Abstract: The present disclosure relates to a system for predicting a future position of road users in a predefined road section, including a storage unit in which at least historical sensor data relating to captured road users in the predefined road section are stored. A processor is provided and extracts the historical movement data relating to the respective road users from the historical sensor data and is further designed to learn a sufficiently accurate high-definition map of the predefined road section by means of a machine learning method based on the historical movement data. The processor is further designed to determine, based on an input of current movement data relating to a road user, a prediction of at least one future position of this road user in this road section, at least implicitly using the learned high-definition map.

Abstract: The present invention concerns antigen binding proteins directed against PRAME protein-derived antigens. The invention in particular provides antigen binding proteins which are specific for the tumor expressed antigen PRAME, wherein the tumor antigen comprises or consists of SEQ ID NO: 50 and is in a complex with a major histocompatibility complex (MHC) protein. The antigen binding proteins of the invention contain, in particular, the complementary determining regions (CDRs) of novel engineered T cell receptors (TCRs) that specifically bind to said PRAME peptide. The antigen binding proteins of the invention are for use in the diagnosis, treatment and prevention of PRAME expressing cancerous diseases. Further provided are nucleic acids encoding the antigen binding proteins of the invention, vectors comprising said nucleic acids, recombinant cells expressing the antigen binding proteins and pharmaceutical compositions comprising the antigen binding proteins of the invention.

Abstract: The present invention pertains to antigen recognizing constructs against COL6A3 antigens. The invention in particular provides novel engineered T cell receptor (TCR) based molecules which are selective and specific for the tumor expressing antigen COL6A3. The TCR of the invention, and COL6A3 antigen binding fragments derived therefrom, are of use for the diagnosis, treatment and prevention of COL6A3 expressing cancerous diseases. Further provided are nucleic acids encoding the antigen recognizing constructs of the invention, vectors comprising these nucleic acids, recombinant cells expressing the antigen recognizing constructs and pharmaceutical compositions comprising the compounds of the invention.

Abstract: The invention relates to a medical instrument having an elongated shaft, a movable tool at a distal end of the shaft, a handle with a movable grip part at a proximal end of the shaft, and a force transmission element which can be moved in the longitudinal direction of the instrument and is operatively connected to the movable grip part and to the tool such that an actuation of the movable grip part is converted into a movement of the tool. The instrument has a spring assembly that is arranged on the handle and has at least one leg spring, which has at least one winding and two legs, and a pin, wherein the at least one winding extends about the pin. When the movable grip part is actuated, a force is applied to at least one of the legs of the leg spring, said force reducing the friction between the winding and the pin such that the leg spring can be rotated about the pin and the force transmission element and the tool can be moved.

Abstract: At an electronic device, a user input is detected that corresponds to a respective user interface element in a portion of a user interface that is associated with a first standard gesture recognizer and a first supplemental gesture recognizer. The user input is processed in accordance with the first standard gesture recognizer and the first supplemental gesture recognizer. In accordance with a determination that content associated with the respective user interface element cannot be added to a drag operation, the device fails to recognize the user input using the first supplemental gesture recognizer, and processes the user input using the first standard gesture recognizer. On the other hand, in accordance with a determination that the content associated with the respective user interface element can be added to the drag operation, a gesture is recognized using the first supplemental gesture recognizer and the content is added to the drag operation.

Abstract: An electronic device, while displaying a user interface of an application, detects a user input on a portion of the user interface associated with a plurality of gesture recognizers. A first set of standard gesture recognizers are associated with the portion of the user interface by the application; a second set of supplemental gesture recognizers are associated with the portion of the user interface by a system process; and a first failure requirement determines which gesture recognizers must fail before other gesture recognizers can recognize a user input. In one example, the first failure requirement is that a particular standard gesture recognizer (e.g., an intensity-based gesture recognizer) must fail before a particular supplemental gesture recognizer (e.g., a drag start gesture recognizer) can recognize a user input.

Abstract: An electronic device, while displaying a user interface of an application, detects a user input on a portion of the user interface associated with a plurality of gesture recognizers. A first set of standard gesture recognizers are associated with the portion of the user interface by the application; a second set of supplemental gesture recognizers are associated with the portion of the user interface by a system process; and a first failure requirement determines which gesture recognizers must fail before other gesture recognizers can recognize a user input. In one example, the first failure requirement is that a particular standard gesture recognizer (e.g., an intensity-based gesture recognizer) must fail before a particular supplemental gesture recognizer (e.g., a drag start gesture recognizer) can recognize a user input.

Abstract: An electronic device, while displaying a user interface for a first application, receives at the first application information that describes a first touch detected at a location on the touch-sensitive surface that corresponds to a respective user interface object. In accordance with a determination that the first touch meets predefined criteria associated with initiating a respective type of interface operation, the device initiates a user interface operation of the respective type involving the respective user interface object. The first application receives instructions to ignore the first touch with respect to user interface operations other than the respective type of interface operation, and ignores the first touch with respect to user interface operations other than the respective type of interface operation. In some embodiments, the respective type of interface operation is a drag operation, for dragging an object in or from a view of the first application.

Abstract: A method and a system for adjustable coating on a substrate using a magnetron sputtering apparatus are provided. The method comprises the steps of providing a magnetron assembly which comprises a plurality of magnets attached to a plurality of yokes and a plurality of actuating mechanisms (208), each operatively coupled to at least one of the plurality of yokes. The method further comprises automatically determining individual positions of each of the plurality of yokes of the magnetron assembly on the basis of at least one parameter, and adjusting individually positions of each of the plurality of yokes of the magnetron assembly in accordance with the automatically determined individual positions.

Abstract: A magnetron assembly for magnetron sputtering with rotary cathode systems is provided. The magnetron assembly comprises a plurality of magnets attached to a plurality of yokes and a plurality of driving modules, each comprising an actuating mechanism operatively coupled to at least one of the plurality of yokes. The plurality of driving modules are adapted for adjusting the position of the plurality of yokes individually.

Abstract: An electronic device, while displaying a user interface for a first application, receives at the first application information that describes a first touch detected at a location on the touch-sensitive surface that corresponds to a respective user interface object. In accordance with a determination that the first touch meets predefined criteria associated with initiating a respective type of interface operation, the device initiates a user interface operation of the respective type involving the respective user interface object. The first application receives instructions to ignore the first touch with respect to user interface operations other than the respective type of interface operation, and ignores the first touch with respect to user interface operations other than the respective type of interface operation. In some embodiments, the respective type of interface operation is a drag operation, for dragging an object in or from a view of the first application.

Abstract: An electronic device, while displaying a user interface for a first application, receives at the first application information that describes a first touch detected at a location on the touch-sensitive surface that corresponds to a respective user interface object. In accordance with a determination that the first touch meets predefined criteria associated with initiating a respective type of interface operation, the device initiates a user interface operation of the respective type involving the respective user interface object. The first application receives instructions to ignore the first touch with respect to user interface operations other than the respective type of interface operation, and ignores the first touch with respect to user interface operations other than the respective type of interface operation. In some embodiments, the respective type of interface operation is a drag operation, for dragging an object in or from a view of the first application.

Abstract: An electronic device, while displaying a user interface for a first application, receives at the first application information that describes a first touch detected at a location on the touch-sensitive surface that corresponds to a respective user interface object. In accordance with a determination that the first touch meets predefined criteria associated with initiating a respective type of interface operation, the device initiates a user interface operation of the respective type involving the respective user interface object. The first application receives instructions to ignore the first touch with respect to user interface operations other than the respective type of interface operation, and ignores the first touch with respect to user interface operations other than the respective type of interface operation. In some embodiments, the respective type of interface operation is a drag operation, for dragging an object in or from a view of the first application.

Abstract: The invention comprises a system and method for employing video in development processes. A new theory of operation for mapping video to formal models is disclosed. The present invention combines a runtime component and an object memory with an transformer component and offers several inputs and outputs. At least one capture device allows input of video. Video is structurally decomposed into shots and annotated following a semiology-based video model and stored in object memory. A runtime component determines the shots that are played back on one or more displays. A spectator may influence the runtime component by changing its state via at least one controller. One or more downstream development processes can access the object memory to extract customary models for requirements specification.

Abstract: The invention comprises a system and method for employing video in development processes. A new theory of operation for mapping video to formal models is disclosed. The present invention combines a runtime component and an object memory with an transformer component and offers several inputs and outputs. At least one capture device allows input of video. Video is structurally decomposed into shots and annotated following a semiology-based video model and stored in object memory. A runtime component determines the shots that are played back on one or more displays. A spectator may influence the runtime component by changing its state via at least one controller. One or more downstream development processes can access the object memory to extract customary models for requirements specification.

Abstract: The invention comprises a system and method for employing video in development processes. A new theory of operation for mapping video to formal models is disclosed. The present invention combines a runtime component and an object memory with an transformer component and offers several inputs and outputs. At least one capture device allows input of video. Video is structurally decomposed into shots and annotated following a semiology-based video model and stored in object memory. A runtime component determines the shots that are played back on one or more displays. A spectator may influence the runtime component by changing its state via at least one controller. One or more downstream development processes can access the object memory to extract customary models for requirements specification. The present invention can play a useful role for development teams that are distributed over large areas by providing common reference points in shots representing the application domain.