Abstract: The invention relates to a ventilator including a ventilation gas source, a ventilation tube assembly, a valve assembly, a flow sensor assembly comprising a distal flow sensor and a proximal flow sensor, a pressure sensor assembly for quantitatively detecting a gas pressure in the ventilation tube assembly a pressure-changing assembly for changing the gas pressure in the ventilation tube assembly and a control device which is designed at least to control the operation of the pressure-changing assembly on the basis of measurement signals from the proximal flow sensor, and on the basis of measurement signals from the proximal flow sensor and from the distal flow sensor, to infer the existence of a fault.

Abstract: An apparatus for manufacturing a three-dimensional object by a layer-by-layer solidification of building material at the points corresponding to the cross-section of the object to be manufactured in a respective layer. The apparatus includes a process chamber in which the object is to be built up layer by layer by selectively solidifying layers of a building material in a build area, a gas supply device, and a recirculating air filter device, wherein the apparatus comprises a pressure stabilization device configured to keep the pressure in the process chamber substantially constant.

Abstract: Disclosed is a method of determining a quality indicator of an object that has been manufactured by layer-wise additive manufacturing. The method includes providing a first dataset that is assigned to a process monitoring device, detecting a relative frequency of occurrence of a process irregularity in a layer and of assigning a grade indicator value to the solidified object cross-section in a layer according to the detected relative frequency, generating a second dataset, in which a grade indicator value is assigned to the object cross-section in each of said several layers following upon one another, and determining a quality indicator by using the second dataset (or several further datasets).

Abstract: Method for calibrating an apparatus for manufacturing a three-dimensional object by layer-wise selective solidification of building material with the step of generating an substantially periodic first modulation pattern in a first sub-area of the build area, the step of generating an substantially periodic second modulation pattern in a second sub-area of the build area, wherein in the overlap zone, the first modulation pattern and the second modulation pattern form an substantially periodic superposition pattern, whose period is larger than the period of the first modulation pattern and the period of the second modulation pattern, the step of detecting the superposition pattern, and the step of determining the deviation of the position of the superposition pattern on the build area from a reference position.

Abstract: The invention relates to a ventilator including a ventilation gas source, a ventilation tube assembly, a valve assembly, a flow sensor assembly comprising a distal flow sensor and a proximal flow sensor, a pressure sensor assembly for quantitatively detecting a gas pressure in the ventilation tube assembly a pressure-changing assembly for changing the gas pressure in the ventilation tube assembly and a control device which is designed at least to control the operation of the pressure-changing assembly on the basis of measurement signals from the proximal flow sensor, and on the basis of measurement signals from the proximal flow sensor and from the distal flow sensor, to infer the existence of a fault.

Abstract: A device is disclosed for producing a three-dimensional object by layerwise construction. The device contains a flow device for generating a gas flow above an applied layer of the building material by means of a nozzle element for introducing the gas into the device. The nozzle element includes a body with a gas inlet side and a gas outlet side, and channels which penetrate the body from the gas inlet side to the gas outlet side, provided with inlet openings on the gas inlet side and gas outlet openings on the gas outlet side, and which are separated by walls. The length of the channels is selected such that a laminar flow is formed at the gas outlet side.

Abstract: Disclosed is a method of determining a quality indicator of an object that has been manufactured by layer-wise additive manufacturing . The method includes providing a first dataset that is assigned to a process monitoring device, detecting a relative frequency of occurrence of a process irregularity in a layer and of assigning a grade indicator value to the solidified object cross-section in a layer according to the detected relative frequency, generating a second dataset, in which a grade indicator value is assigned to the object cross-section in each of said several layers following upon one another, and determining a quality indicator by using the second dataset (or several further datasets).

Abstract: An apparatus for manufacturing a three-dimensional object by a layer-by-layer solidification of building material at the points corresponding to the cross-section of the object to be manufactured in a respective layer. The apparatus includes a process chamber in which the object is to be built up layer by layer by selectively solidifying layers of a building material in a build area, a gas supply device, and a recirculating air filter device, wherein the apparatus comprises a pressure stabilization device configured to keep the pressure in the process chamber substantially constant.

Abstract: Method for calibrating an apparatus for manufacturing a three-dimensional object by layer-wise selective solidification of building material with the step of generating an substantially periodic first modulation pattern in a first sub-area of the build area, the step of generating an substantially periodic second modulation pattern in a second sub-area of the build area, wherein in the overlap zone, the first modulation pattern and the second modulation pattern form an substantially periodic superposition pattern, whose period is larger than the period of the first modulation pattern and the period of the second modulation pattern, the step of detecting the superposition pattern, and the step of determining the deviation of the position of the superposition pattern on the build area from a reference position.

Abstract: A valve includes a housing, in which a first valve body is accommodated so that it is moveable in a direction of a longitudinal axis, a first valve seat configured to be closed by the first valve body and arranged on the housing, a first fluid flow path extending from a first connection via the first valve seat to a second connection, a second valve seat closeable by a moveable second valve body, the second valve body formed separately from the first valve body, a second fluid flow path extending from the first connection via a bypass duct in the first valve body, onwards via the second valve seat to the second connection, so that pressure at the first connection is limited upwardly by the first and the second valve body in that hydraulic fluid is led to the second connection via the first fluid flow path.

Abstract: A device (1), for producing a three-dimensional object (2) by solidifying, layer-by-layer, building material (13) at locations in the respective layer corresponding to the cross-section of the object (2) to be produced, contains a flow device (31, 32, 34, 35) for generating a gas flow above an applied layer of the building material (13) by means of a nozzle element (40) for introducing the gas into the device. The nozzle element (40) comprises a body (41) with a gas inlet side and a gas outlet side (46), and a plurality of channels (42) which penetrate the body from the gas inlet side (44) to the gas outlet side (46), are provided with inlet openings on the gas inlet side (44) and with gas outlet openings (47) on the gas outlet side (46), and which are separated by walls (43). The length of the channels (42) is selected such that therein a laminar flow is formed at the gas outlet side (46).

Abstract: A valve includes a housing, in which a first valve body is accommodated so that it is moveable in a direction of a longitudinal axis, a first valve seat configured to be closed by the first valve body and arranged on the housing, a first fluid flow path extending from a first connection via the first valve seat to a second connection, a second valve seat closeable by a moveable second valve body, the second valve body formed separately from the first valve body, a second fluid flow path extending from the first connection via a bypass duct in the first valve body, onwards via the second valve seat to the second connection, so that pressure at the first connection is limited upwardly by the first and the second valve body in that hydraulic fluid is led to the second connection via the first fluid flow path.

Abstract: The invention relates to an in vitro or ex vivo method for increasing the immunoreactivity of cells of the immune system, which were contacted with an antigen, said method comprising the reduction or inhibition of the Cbl-b function of said cells, thereby increasing the immunoreactivity of the cells towards the antigen.

Abstract: The present invention relates to methods of determining intracellular Cbl-b protein in cells of a sample, comprising introducing an antibody, which binds Cbl-b intracellularly, into a cell, allowing contracting of the antibody and Cbl-b protein potentially present in the cell, detecting binding events between the antibody and Cbl-b, quantifying the detected binding events, whereby the content of Cbl-b protein is determined.

Abstract: The invention relates to an in vitro or ex vivo method for increasing the immunoreactivity of cells of the immune system, which were contacted with an antigen, said method comprising the reduction or inhibition of the Cbl-b function of said cells, thereby increasing the immunoreactivity of the cells towards the antigen.