Patents by Inventor Dominique Boutriau
Dominique Boutriau has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11241495Abstract: The present application discloses an immunogenic composition comprising N. meningitidis capsular polysaccharides from at least one of serogroups A, C, W135 and Y conjugated to a carrier protein to produce a N. meningitidis capsular polysaccharide conjugate, wherein the average size of each N. meningitidis polysaccharide is above 50 kDa.Type: GrantFiled: November 2, 2018Date of Patent: February 8, 2022Assignee: Glaxosmithkline Biologicals S.A.Inventors: Ralph Leon Biemans, Dominique Boutriau, Carine Capiau, Philippe Denoel, Pierre Duvivier, Jan Poolman
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Publication number: 20200000911Abstract: The present application discloses an immunogenic composition comprising at least 2 different N. meningitidis capsular saccharides, wherein one or more is/are selected from a first group consisting of MenA, MenC, MenY and MenW which is/are conjugated through a linker to a carrier protein(s), and one or more different saccharides is/are selected from a second group consisting of MenA, MenC, MenY and MenW which is/are directly conjugated to a carrier protein(s).Type: ApplicationFiled: February 5, 2019Publication date: January 2, 2020Inventors: Ralph Leon Biemans, Dominique Boutriau, Carine Capiau, Philippe Denoel, Pierre Duvivier, Jan Poolman
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Publication number: 20190298822Abstract: present application discloses an immunogenic composition comprising N. meningitidis capsular polysaccharides from at least one of serogroups A, C, W135 and Y conjugated to a carrier protein to produce a N. meningitidis capsular polysaccharide conjugate, wherein the average size of each N. meningitidis polysaccharide is above 50 kDa.Type: ApplicationFiled: November 2, 2018Publication date: October 3, 2019Inventors: Ralph Leon Biemans, Dominique Boutriau, Carine Capiau, Philippe Denoel, Pierre Duvivier, Jan Poolman
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Patent number: 10245317Abstract: The present application discloses an immunogenic composition comprising at least 2 different N. meningitidis capsular saccharides, wherein one or more is/are selected from a first group consisting of MenA, MenC, MenY and MenW which is/are conjugated through a linker to a carrier protein(s), and one or more different saccharides is/are selected from a second group consisting of MenA, MenC, MenY and MenW which is/are directly conjugated to a carrier protein(s).Type: GrantFiled: September 14, 2016Date of Patent: April 2, 2019Assignee: GLAXOSMITHKLINE BIOLOGICALS S.A.Inventors: Ralph Leon Biemans, Dominique Boutriau, Carine Capiau, Philippe Denoel, Pierre Duvivier, Jan Poolman
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Patent number: 10166287Abstract: present application discloses an immunogenic composition comprising N. meningitidis capsular polysaccharides from at least one of serogroups A, C, W135 and Y conjugated to a carrier protein to produce a N. meningitidis capsular polysaccharide conjugate, wherein the average size of each N. meningitidis polysaccharide is above 50 kDa.Type: GrantFiled: August 30, 2017Date of Patent: January 1, 2019Assignee: GLAXOSMITHKLINE BIOLOGICALS S.A.Inventors: Ralph Leon Biemans, Dominique Boutriau, Carine Capiau, Philippe Denoel, Pierre Duvivier, Jan Poolman
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Patent number: 10130694Abstract: The present invention relates to immunogenic compositions comprising a Clostridium difficile (C. difficile) polypeptide and an aluminum-free adjuvant.Type: GrantFiled: May 26, 2017Date of Patent: November 20, 2018Assignee: GLAXOSMITHKLINE BIOLOGICALS S.A.Inventors: Dominique Boutriau, Sophie Marie Jeanne Valentine Germain, Hugues Wallemacq
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Publication number: 20180104322Abstract: This application relates to immunogenic compositions comprising a Staphylococcus aureus Type 5 capsular saccharide conjugated to a carrier protein to form a S. aureus Type 5 capsular saccharide conjugate.Type: ApplicationFiled: December 5, 2017Publication date: April 19, 2018Applicant: GLAXOSMITHKLINE BIOLOGICALS, SAInventors: Ralph Leon BIEMANS, Dominique BOUTRIAU, Philippe Thomas DENOEL, Pierre DUVIVIER, Carine GORAJ
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Patent number: 9931397Abstract: The present application relates to an immunogenic composition comprising at least 2 conjugates of N. meningitidis capsular saccharide and protein carrier, wherein said conjugates comprise at least 2 different N. meningitidis capsular saccharides selected from the group consisting of MenA, MenC, MenY and MenW, wherein at least one capsular saccharide is conjugated to a protein carrier with a saccharide:protein ratio (w/w) between 1:2-1:5, and wherein at least one different capsular saccharide is conjugated to a protein carrier with a saccharide:protein ratio (w/w) between 5:1-1:1.99.Type: GrantFiled: June 23, 2006Date of Patent: April 3, 2018Assignee: GLAXOSMITHKLINE BIOLOGICALS S.A.Inventors: Ralph Leon Biemans, Dominique Boutriau, Carine Capiau, Philippe Denoel, Pierre Duvivier, Jan Poolman
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Publication number: 20180064806Abstract: present application discloses an immunogenic composition comprising N. meningitidis capsular polysaccharides from at least one of serogroups A, C, W135 and Y conjugated to a carrier protein to produce a N. meningitidis capsular polysaccharide conjugate, wherein the average size of each N. meningitidis polysaccharide is above 50 kDa.Type: ApplicationFiled: August 30, 2017Publication date: March 8, 2018Inventors: Ralph Leon Biemans, Dominique Boutriau, Carine Capiau, Philippe Denoel, Pierre Duvivier, Jan Poolman
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Publication number: 20170340719Abstract: The present invention relates to immunogenic compositions comprising a Clostridium difficile (C. difficile) polypeptide and an aluminium-free adjuvant.Type: ApplicationFiled: May 26, 2017Publication date: November 30, 2017Applicant: GLAXOSMITHKLINE BIOLOGICALS S.A.Inventors: Dominique BOUTRIAU, Sophie Marie Jeanne Valentine GERMAIN, Hugues WALLEMACQ
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Patent number: 9789179Abstract: The present application discloses an immunogenic composition comprising N. meningitidis capsular polysaccharides from at least one of serogroups A, C, W135 and Y conjugated to a carrier protein to produce a N. meningitidis capsular polysaccharide conjugate, wherein the average size of each N. meningitidis polysaccharide is above 50 kDa.Type: GrantFiled: June 23, 2006Date of Patent: October 17, 2017Assignee: GLAXOSMITHKLINE BIOLOGICALS S.A.Inventors: Ralph Leon Biemans, Dominique Boutriau, Carine Capiau, Philippe Denoel, Pierre Duvivier, Jan Poolman
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Publication number: 20170281744Abstract: The application discloses a method of immunising against Staphylococcus aureus infection comprising a step of administering to a human patient a single dose of an immunogenic composition comprising; (i) a Staphylococcus aureus ClfA protein or immunogenic fragment thereof at a dose of 5-50, 10-30, 5-15 or 20-40 ?g and (ii) a pharmaceutically acceptable excipient; wherein the pH of the composition is pH 5.0-pH 8.0. The application further discloses an immunogenic composition comprising; (i) a S. aureus Type 5 capsular saccharide conjugated to a carrier protein, (ii) a S. aureus Type 8 capsular saccharide conjugated to a carrier protein, (iii) a ClfA protein or immunogenic fragment thereof, (iv) an alpha toxoid, and (v) a pharmaceutically acceptable excipient; wherein the pH of the immunogenic composition is pH 5.0-pH 8.Type: ApplicationFiled: December 8, 2015Publication date: October 5, 2017Inventors: Ralph Leon BIEMANS, Dominique BOUTRIAU, Philippe DENOEL, Pierre DUVIVIER, Carine GORAJ
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Patent number: 9694064Abstract: The present invention relates to immunogenic compositions comprising a Clostridium difficile (C. difficile) polypeptide and an aluminum-free adjuvant.Type: GrantFiled: December 3, 2013Date of Patent: July 4, 2017Assignee: GLAXOSMITHKLINE BIOLOGICALS S.A.Inventors: Dominique Boutriau, Sophie Marie Jeanne Valentine Germain, Hugues Wallemacq
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Publication number: 20170065714Abstract: The present application discloses an immunogenic composition comprising at least 2 different N. meningitidis capsular saccharides, wherein one or more is/are selected from a first group consisting of MenA, MenC, MenY and MenW which is/are conjugated through a linker to a carrier protein(s), and one or more different saccharides is/are selected from a second group consisting of MenA, MenC, MenY and MenW which is/are directly conjugated to a carrier protein(s).Type: ApplicationFiled: September 14, 2016Publication date: March 9, 2017Inventors: Ralph Leon Biemans, Dominique Boutriau, Carine Capiau, Philippe Denoel, Pierre Duvivier, Jan Poolman
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Publication number: 20170056490Abstract: This application relates to immunogenic compositions comprising a Staphylococcus aureus Type 5 capsular saccharide conjugated to a carrier protein to form a S. aureus Type 5 capsular saccharide conjugate.Type: ApplicationFiled: November 15, 2016Publication date: March 2, 2017Applicant: GLAXOSMITHKLINE BIOLOGICALS S.A.Inventors: Ralph Leon BIEMANS, Dominique BOUTRIAU, Philippe DENOEL, Pierre DUVIVIER, Carine GORAJ
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Patent number: 9486515Abstract: The present application discloses an immunogenic composition comprising at least 2 different N. meningitidis capsular saccharides, wherein one or more is/are selected from a first group consisting of MenA, MenC, MenY and MenW which is/are conjugated to a protein carrier(s) wherein the saccharide:protein ratio (w/w) is between 1:2-1:5, and one or more different saccharides is/are selected from a second group consisting of MenA, MenC, MenY and MenW which is/are conjugated to a protein carrier(s) wherein the saccharide:protein ratio (w/w) is between 5:1-1:1.99.Type: GrantFiled: June 23, 2006Date of Patent: November 8, 2016Assignee: GLAXOSMITHKLINE BIOLOGICALS S.A.Inventors: Ralph Leon Biemans, Dominique Boutriau, Carine Capiau, Philippe Denoel, Pierre Duvivier, Jan Poolman
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Patent number: 9358279Abstract: The present application discloses an immunogenic composition comprising a Hib saccharide conjugate, at least one additional bacterial, for example N. meningitidis, saccharide conjugate(s), and a further antigen selected from the group consisting of whole cell pertussis and hepatitis B surface antigen, wherein the saccharide dose of the Hib saccharide conjugate is less than 5 ?g.Type: GrantFiled: October 28, 2014Date of Patent: June 7, 2016Assignee: GLAXOSMITHKLINE BIOLOGICALS S.A.Inventors: Ralph Leon Biemans, Dominique Boutriau, Carine Capiau, Philippe Denoel, Pierre Duvivier, Jan Poolman
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Publication number: 20160129101Abstract: This application relates to immunogenic compositions comprising a Staphylococcus aureus Type 5 capsular saccharide conjugated to a carrier protein to form a S. aureus Type 5 capsular saccharide conjugate.Type: ApplicationFiled: June 3, 2014Publication date: May 12, 2016Inventors: Ralph Leon BIEMANS, Dominique BOUTRIAU, Philippe DENOEL, Pierre DUVIVIER, Carine GORAJ
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Patent number: 9233151Abstract: A multi-valent vaccine composition is described comprising a conjugate of the capsular polysaccharide of H. influenzae b not adsorbed onto an aluminum adjuvant salt, and two or more further bacterial polysaccharides. A multi-valent vaccine composition is also described comprising a whole-cell pertussis component, tetanus toxoid, diphtheria toxoid, Hepatitis B surface antigen, a conjugate of the capsular polysaccharide of H. influenzae b, and a conjugate of a capsular polysaccharide of N. meningitidis type A or C (or both). Furthermore, a multi-valent vaccine composition is described comprising a whole-cell pertussis component, tetanus toxoid, diphtheria toxoid, and a low dose of a conjugate of the capsular polysaccharide of H. influenzae b.Type: GrantFiled: April 4, 2012Date of Patent: January 12, 2016Assignee: GlaxoSmithKline Biologicals S.A.Inventors: Dominique Boutriau, Carine Capiau, Pierre Michel Desmons, Dominique Lemoine, Jan Poolman
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Publication number: 20150313984Abstract: The present invention relates to immunogenic compositions comprising a Clostridium difficile (C.difficile) polypeptide and an aluminium-free adjuvant.Type: ApplicationFiled: December 3, 2013Publication date: November 5, 2015Inventors: Dominique BOUTRIAU, Sophie Marie Jeanne Valentine GERMAIN, Hugues WALLEMACQ