Abstract: A polypeptide having a nucleoside or nucleotide kinase activity, which comprises a wild-type nucleoside or nucleotide kinase mutated at at least one amino acid position within the active site of nucleoside or nucleotide kinase to increase kinase catalytic activity towards a given nucleotide or nucleoside analog compared to the wild-type nucleoside or nucleotide kinase. A polynucleotide coding for said polypeptide. Methods, including therapeutic ones, using said polypeptide and polynucleotide.

Abstract: The invention concerns a gliding board, especially a snowboard, which is intended to support both boots of a skier. The board includes a base structure of which at least the front end is turned up to form the shovel. It further has a central zone with two mounting zones for the binding elements, a front zone, and a rear zone. The board has, at least in one of the front or rear zones, a long reinforcement shaped according to the length and width of the zone. The reinforcement extends from the vicinity of the end of the front or rear zone to at least the vicinity of the mounting zone located near the zone.

Abstract: An assembly adapted for use in skiing, particularly alternating steps skiing. The assembly includes in particular a ski and an assembly for increasing the rigidity in flexion of the ski, in a manner so as to preserve or increase the lifting in the vertical direction of the lower surface of the ski, at least in a portion of the gripping zone, during the lowering of the heel of the foot. This assembly includes in particular a plate, positioned above the upper surface and maintained by linkage elements.

Abstract: The invention concerns a gliding board, especially a snowboard, which is intended to support both boots of a skier. The board includes a base structure of which at least the front end is turned up to form the shovel. It further has a central zone with two mounting zones for the binding elements, a front zone, and a rear zone. The board has, at least in one of the front or rear zones, a long reinforcement shaped according to the length and width of the zone. The reinforcement extends from the vicinity of the end of the front or rear zone to at least the vicinity of the mounting zone located near the zone.

Abstract: Ski shaped like an elongated beam, comprising a lower slide face bounded laterally by two lower edges, an upper face bounded laterally by two upper edges, and two lateral faces, the ski being constituted by a central part extended toward the front by a front part ending, at its front end, by the tip and extended toward the rear by a rear part ending, at its rear end, in the heel-piece. The front part is constituted by a front section connected to the central part by a front intermediate connection section, while this rear part is formed by a rear section connected to the central part by a rear intermediate connection section. The two upper edges of the upper surface are parallel in the central part, while one of the two front or rear section is such that, in this area, first, the lateral faces are inclined so as to converge upward, and second, the upper surface is narrower than it is in the central part and has a uniform width.

Abstract: A racket for a racket sport has a frame having a handle and an annular frame head carried on the handle and formed with throughgoing stringing holes each having an outer end and an inner end. Liners define rigid edges around the outer edges of at least selected ones of the holes and strings pass through the holes in the frame, those strings passing through the selected ones of the holes being bent around and in contact with the rigid edges thereof. Respective pliable washers received in the selected ones of the holes offset from the respective ridged edges thereof each have an inner periphery elastically hugging the string traversing the respective hole for damping vibration in the head and an outer periphery fixed relative to the frame head.

Abstract: A strung racket having a racket head in the form of a frame strung with stringing including longitudinal strings passing between a crown and a bottom of the frame and transverse strings extending transversely to the longitudinal strings between sides of the frame, the strings passing through holes in the frame. A device for damping vibration of the stringing generated by impact of the stringing with a ball, is provided and includes at least one pliable membrance fixedly received in at least one of the holes of the bottom of the frame and having an orifice tranversed by the respective string, the edge of the pliable membrane hugging the string traversing the frame hole.

Abstract: A tennis racket has an elongated handle defining a longitudinal main axis and having an outer end and an annular frame fixed to the outer handle end and bisected by the axis. The frame has an arcuate crown concave toward the handle and an arcuate throat concave toward the handle and of substantially the same transverse size and curvature as the crown. The crown and throat are formed with respective longitudinally aligned sets of longitudinally throughgoing and transversely spaced holes. In addition the frame has a pair of sides substantially symmetrically flanking the axis and longitudinally bridging the crown and throat. These sides are formed with respective transversely aligned sets of transversely throughgoing and longitudinally spaced holes. The crown and sides together define an oval outer periphery. The side holes open outward at their outer ends into respective outwardly open grooves in the sides of the frame.