Patents by Inventor Dominique Dufayet

Dominique Dufayet has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Induction of beta cell differentiation in human cells
    Publication number: 20050214269
    Abstract: The present invention provides methods for inducing insulin gene expression in cultured pancreas cells, the method comprising contacting a culture of endocrine pancreas cells expressing a PDX-1 gene and a NeuroD/BETA2 gene with a GLP-1 receptor agonist, wherein the cells have been cultured under conditions such that the cells are in contact with other cells in the culture, thereby inducing insulin gene expression in the cells. The invention also provides high throughput screening methods for modulators of ?-cell function, stable cultures of cells made by the methods of the invention, and methods of treating a human subject using the methods of the invention.
    Type: Application
    Filed: May 9, 2005
    Publication date: September 29, 2005
    Applicant: The Regents of the University of California
    Inventors: Fred Levine, Dominique Dufayet, Pamela Itkin-Ansari
  • Induction of beta cell differentiation in human cells by stimulation of the GLP-1 receptor
    Publication number: 20050163763
    Abstract: The present invention provides methods for inducing insulin gene expression in cultured pancreas cells, the method comprising contacting a culture of endocrine pancreas cells expressing a PDX-1 gene with a GLP-1 receptor agonist, wherein the cells have been cultured under conditions such that the cells are in contact with other cells in the culture, thereby inducing insulin gene expression in the cells. The invention also provides high throughput screening methods for modulators of ?-cell function, stable cultures of cells made by the methods of the invention, and methods of treating a human subject using the methods of the invention.
    Type: Application
    Filed: January 19, 2005
    Publication date: July 28, 2005
    Applicant: The Regents of the University of California
    Inventors: Fred Levine, Dominique Dufayet
  • Induction of beta cell differentiation in human cells by stimulation of the GLP-1 receptor
    Patent number: 6884585
    Abstract: The present invention provides methods for inducing insulin gene expression in cultured pancreas cells, the method comprising contacting a culture of endocrine pancreas cells expressing a PDX-1 gene with a GLP-1 receptor agonist, wherein the cells have been cultured under conditions such that the cells are in contact with other cells in the culture, thereby inducing insulin gene expression in the cells. The invention also provides high throughput screening methods for modulators of ?-cell function, stable cultures of cells made by the methods of the invention, and methods of treating a human subject using the methods of the invention.
    Type: Grant
    Filed: May 30, 2002
    Date of Patent: April 26, 2005
    Assignee: The Regents of the University of California
    Inventors: Fred Levine, Dominique Dufayet
  • Induction of beta cell differentiation in human cells by stimulation of the GLP-1 receptor
    Publication number: 20020151065
    Abstract: The present invention provides methods for inducing insulin gene expression in cultured pancreas cells, the method comprising contacting a culture of endocrine pancreas cells expressing a PDX-1 gene with a GLP-1 receptor agonist, wherein the cells have been cultured under conditions such that the cells are in contact with other cells in the culture, thereby inducing insulin gene expression in the cells. The invention also provides high throughput screening methods for modulators of &bgr;-cell function, stable cultures of cells made by the methods of the invention, and methods of treating a human subject using the methods of the invention.
    Type: Application
    Filed: May 30, 2002
    Publication date: October 17, 2002
    Applicant: The Regents of the University of California
    Inventors: Fred Levine, Dominique Dufayet
  • Inducing insulin gene expression in pancreas cells expressing recombinant PDX-1
    Patent number: 6448045
    Abstract: The present invention provides methods for inducing insulin gene expression in cultured pancreas cells, the method comprising contacting a culture of endocrine pancreas cells expressing a PDX-1 gene with a GLP-1 receptor agonist, wherein the cells have been cultured under conditions such that the cells are in contact with other cells in the culture, thereby inducing insulin gene expression in the cells. The invention also provides high throughput screening methods for modulators of &bgr;-cell function, stable cultures of cells made by the methods of the invention, and methods of treating a human subject using the methods of the invention.
    Type: Grant
    Filed: March 10, 2000
    Date of Patent: September 10, 2002
    Assignee: The Regents of the University of California
    Inventors: Fred Levine, Dominique Dufayet