Patents by Inventor Dominique Gouty

Dominique Gouty has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Induction of ? cell differentiation in human cells by stimulation of the GLP-1 receptor
    Patent number: 7276352
    Abstract: The present invention provides methods for inducing insulin gene expression in cultured pancreas cells, the method comprising contacting a culture of endocrine pancreas cells expressing a PDX-1 gene with a GLP-1 receptor agonist, wherein the cells have been cultured under conditions such that the cells are in contact with other cells in the culture, thereby inducing insulin gene expression in the ceils. The invention also provides methods of treating a diabetic human subject using the methods of the invention.
    Type: Grant
    Filed: January 19, 2005
    Date of Patent: October 2, 2007
    Assignee: The Regents of the University of California
    Inventors: Fred Levine, Dominique Gouty
  • Induction of a Beta Cell Differentiation in Human Cells
    Publication number: 20060210963
    Abstract: The present invention provides methods for inducing insulin gene expression in cultured pancreas cells, the method comprising contacting a culture of endocrine pancreas cells expressing a PDX-1 gene and a NeuroD/BETA2 gene with a GLP-1 receptor agonist, wherein the cells have been cultured under conditions such that the cells are in contact with other cells in the culture, thereby inducing insulin gene expression in the cells. The invention also provides high throughput screening methods for modulators of ?-cell function, stable cultures of cells made by the methods of the invention, and methods of treating a human subject using the methods of the invention.
    Type: Application
    Filed: June 5, 2006
    Publication date: September 21, 2006
    Applicant: The Regents of the University of California
    Inventors: Fred Levine, Dominique Gouty, Pamela Itkin-Ansari
  • Induction of beta cell differentiation in human cells
    Patent number: 6911324
    Abstract: The present invention provides methods for inducing insulin gene expression in cultured pancreas cells, the method comprising contacting a culture of endocrine pancreas cells expressing a PDX-1 gene and a NeuroD/BETA2 gene with a GLP-1 receptor agonist, wherein the cells have been cultured under conditions such that the cells are in contact with other cells in the culture, thereby inducing insulin gene expression in the cells. The invention also provides high throughput screening methods for modulators of ?-cell function, stable cultures of cells made by the methods of the invention, and methods of treating a human subject using the methods of the invention.
    Type: Grant
    Filed: October 18, 2001
    Date of Patent: June 28, 2005
    Assignee: The Regents of the University of California
    Inventors: Fred Levine, Dominique Gouty, Pamela Itkin-Ansari
  • Induction of beta cell differentiation in human cells
    Publication number: 20030077259
    Abstract: The present invention provides methods for inducing insulin gene expression in cultured pancreas cells, the method comprising contacting a culture of endocrine pancreas cells expressing a PDX-1 gene and a NeuroD/BETA2 gene with a GLP-1 receptor agonist, wherein the cells have been cultured under conditions such that the cells are in contact with other cells in the culture, thereby inducing insulin gene expression in the cells. The invention also provides high throughput screening methods for modulators of &bgr;-cell function, stable cultures of cells made by the methods of the invention, and methods of treating a human subject using the methods of the invention.
    Type: Application
    Filed: October 18, 2001
    Publication date: April 24, 2003
    Applicant: The Regents of the University of California
    Inventors: Fred Levine, Dominique Gouty, Pamela Itkin-Ansari