Patents by Inventor Dominique Grimler

Dominique Grimler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Chemical process for preparing spiroindolones and intermediates thereof
    Patent number: 9598712
    Abstract: The present invention relates to processes and intermediates useful for the manufacture of spiroindolone compounds such as (1?R,3?S)-5,7?-dichloro-6?-fluoro-3?-methyl-2?,3?,4?,9?-tetrahydrospiro[indoline-3,1?-pyrido[3,4-b]indol]-2-one and salts and hydrates and solvates thereof.
    Type: Grant
    Filed: March 22, 2013
    Date of Patent: March 21, 2017
    Assignee: Novartis AG
    Inventors: Michael Crowe, Michael Foulkes, Giancarlo Francese, Dominique Grimler, Ernst Kuesters, Kurt Laumen, Yunzhong Li, Changxue Lin, Jovana Nazor, Thomas Ruch, Derek Smith, Shiwei Song, Shangjun Teng
  • Chemical Process for Preparing Spiroindolones and Intermediates Thereof
    Publication number: 20150045562
    Abstract: The present invention relates to processes and intermediates useful for the manufacture of spiroindolone compounds such as (1?R,3?S)-5,7?-dichloro-6?-fluoro-3?-methyl-2?,3?,4?,9?-tetrahydrospiro[indoline-3,1?-pyrido[3,4-b]indol]-2-one and salts and hydrates and solvates thereof.
    Type: Application
    Filed: March 22, 2013
    Publication date: February 12, 2015
    Applicant: Novartis AG
    Inventors: Michael Crowe, Michael Foulkes, Giancarlo Francese, Dominique Grimler, Ernst Kuesters, Kurt Laumen, Yunzhong Li, Changxue Lin, Jovana Nazor, Thomas Ruch, Derek Smith, Shiwei Song, Shangjun Teng
  • OPTICAL ISOMERS OF AN ILOPERIDONE METABOLITE
    Publication number: 20130296366
    Abstract: The present invention relates to novel isomers of a metabolite of Iloperidone, their preparation, their use as pharmaceuticals and pharmaceutical compositions containing them.
    Type: Application
    Filed: October 26, 2012
    Publication date: November 7, 2013
    Inventors: Dominique Grimler, Hans O. Kalkman, Hequn Yin
  • Optical isomers of an iloperidone metabolite
    Patent number: 8314129
    Abstract: The present invention relates to novel isomers of a metabolite of Iloperidone, their preparation, their use as pharmaceuticals and pharmaceutical compositions containing them.
    Type: Grant
    Filed: April 28, 2011
    Date of Patent: November 20, 2012
    Assignee: Novartis AG
    Inventors: Dominique Grimler, Hans O. Kalkman, Hequn Yin
  • PROCESS FOR THE MANUFACTURE OF ORGANIC COMPOUNDS
    Publication number: 20120238761
    Abstract: The present invention relates to processes for the manufacture of an angiotensin receptor blocker (ARB; also called angiotension II receptor antagonist or AT1 receptor antagonist) and salts thereof, to novel intermediates and process steps.
    Type: Application
    Filed: October 25, 2010
    Publication date: September 20, 2012
    Inventors: Gottfried Sedelmeier, Florian Andreas Rampf, Dominique Grimler
  • 3-alkyl-5- (4-alkyl-5-oxo-tetrahydrofutran-2-yl) pyrrolidin-2-one derivatives as intermediates in the synthesis of renin inhibitors
    Patent number: 8198465
    Abstract: The invention related to a novel process, novel process steps and novel intermediates useful in the synthesis of pharmaceutically active compounds, especially renin inhibitors, such as Aliskiren. Inter alia, the invention relates to a process for the manufacture of a compound of the formula II, or a salt thereof, and a compound of formula VI or a salt thereof, wherein R3 and R4 as well as Act are as defined in the specification, and processes of manufacturing these. Additionally transformation of compounds (VI) with metallo organic compounds (VII) give rise to the new compounds (VIII) which are direct precursors for the preparation of Aliskiren.
    Type: Grant
    Filed: June 25, 2010
    Date of Patent: June 12, 2012
    Assignee: Novartis AG
    Inventors: Gottfried Sedelmeier, Dominique Grimler, Murat Acemoglu
  • OPTICAL ISOMERS OF AN ILOPERIDONE METABOLITE
    Publication number: 20110201646
    Abstract: The present invention relates to novel isomers of a metabolite of Iloperidone, their preparation, their use as pharmaceuticals and pharmaceutical compositions containing them.
    Type: Application
    Filed: April 28, 2011
    Publication date: August 18, 2011
    Inventors: Dominique Grimler, Hans O. Kalkman, Hequn Yin
  • Optical isomers of an Iloperidone metabolite
    Patent number: 7977356
    Abstract: The present invention relates to novel isomers of a metabolite of Iloperidone, their preparation, their use as pharmaceuticals and pharmaceutical compositions containing them.
    Type: Grant
    Filed: March 13, 2009
    Date of Patent: July 12, 2011
    Assignee: Novartis AG
    Inventors: Dominique Grimler, Hans O. Kalkman, Hequn Yin
  • 3-Alkyl-5- (4-alkyl-5-oxo-tetrahydrofutran-2-yl) pyrrolidin-2-one Derivatives as Intermediates in the Synthesis of Renin Inhibitors
    Publication number: 20100267965
    Abstract: The invention related to a novel process, novel process steps and novel intermediates useful in the synthesis of pharmaceutically active compounds, especially renin inhibitors, such as Aliskiren. Inter alia, the invention relates to a process for the manufacture of a compound of the formula II, or a salt thereof, and a compound of formula VI or a salt thereof, wherein R3 and R4 as well as Act are as defined in the specification, and processes of manufacturing these. Additionally transformation of compounds (VI) with metallo organic compounds (VII) give rise to the new compounds (VIII) which are direct precursors for the preparation of Aliskiren.
    Type: Application
    Filed: June 25, 2010
    Publication date: October 21, 2010
    Inventors: Gottfried Sedelmeier, Dominique Grimler, Murat Acemoglu
  • 3-alkyl-5- (4-alkyl-5-oxo-tetrahydrofutran-2-yl) pyrrolidin-2-one derivatives as intermediates in the synthesis of renin inhibitors
    Patent number: 7772405
    Abstract: The invention related to a novel process, novel process steps and novel intermediates useful in the synthesis of pharmaceutically active compounds, especially renin inhibitors, such as Aliskiren. Inter alia, the invention relates to a process for the manufacture of a compound of the formula II, or a salt thereof, and a compound of formula VI or a salt thereof, wherein R3 and R4 as well as Act are as defined in the specification, and processes of manufacturing these. Additionally transformation of compounds (VI) with metallo organic compounds (VII) give rise to the new compounds (VIII) which are direct precursors for the preparation of Aliskiren.
    Type: Grant
    Filed: October 16, 2006
    Date of Patent: August 10, 2010
    Assignee: Novartis AG
    Inventors: Gottfried Sedelmeier, Dominique Grimler, Murat Acemoglu
  • Metal salts of 2?-(1H-Tetrazol-5yl)-1.1?-biphenyl-4-carboxaldehyde
    Patent number: 7728024
    Abstract: The invention relates to a method or process for the manufacture of blood pressure lowering agents, such as valsartan, novel intermediates as well as process steps in said synthesis. The method or process leads via the novel intermediate salts of the formula IA, or a tautomer thereof, wherein [kat]n+ is a cation and n is 1, 2, 3, 4, 5 or 6.
    Type: Grant
    Filed: July 10, 2006
    Date of Patent: June 1, 2010
    Assignee: Novartis AG
    Inventors: Gottfried Sedelmeier, Dominique Grimler
  • OPTICAL ISOMERS OF AN ILOPERIDONE METABOLITE
    Publication number: 20090176739
    Abstract: The present invention relates to novel isomers of a metabolite of Iloperidone, their preparation, their use as pharmaceuticals and pharmaceutical compositions containing them.
    Type: Application
    Filed: March 13, 2009
    Publication date: July 9, 2009
    Inventors: Dominique Grimler, Hans O. Kalkman, Hequn Yin
  • 3-Alkyl-5- (4-Alkyl-5-Oxo-Tetrahydrofutr An -2-Yl) Pyrrolidin-2-One Derivatives As Intermediates In The Synthesis Of Renin Inhibitors
    Publication number: 20080262246
    Abstract: The invention related to a novel process, novel process steps and novel intermediates useful in the synthesis of pharmaceutically active compounds, especially renin inhibitors, such as Aliskiren. Inter alia, the invention relates to a process for the manufacture of a compound of the formula II, or a salt thereof, and a compound of formula VI or a salt thereof, wherein R3 and R4 as well as Act are as defined in the specification, and processes of manufacturing these. Additionally transformation of compounds (VI) with metallo organic compounds (VII) give rise to the new compounds (VIII) which are direct precursors for the preparation of Aliskiren.
    Type: Application
    Filed: October 16, 2006
    Publication date: October 23, 2008
    Inventors: Gottfried Sedelmeier, Dominique Grimler, Murat Acemoglu
  • Metal Salts of 2' - (1H-Tetrazol-5Yl) -1. 1'-Biphenyl-4-Carboxaldehyde
    Publication number: 20080234490
    Abstract: The invention relates to a method or process for the manufacture of blood pressure lowering agents, such as valsartan, novel intermediates as well as process steps in said synthesis. The method or process leads via the novel intermediate salts of the formula IA, or a tautomer thereof, wherein [Kat]n+ is a cation and n is 1, 2, 3, 4, 5 or 6.
    Type: Application
    Filed: July 10, 2006
    Publication date: September 25, 2008
    Inventors: Gottfried Sedelmeier, Dominique Grimler
  • Enantioselective process for the preparation of both enantiomers of 10,11-dihydro-10-hydroxy-5h-dibenz[b,f]azepine-5-carboxamide and new crystal forms thereof
    Publication number: 20060142566
    Abstract: The invention relates to a novel process for the manufacture of substituted enantiopure 10hydroxy-dihydrodibenz[b,f]azepines (Ia), (Ib) wherein each of R1 and R2, independently, are hydrogen, halogen, amino or nitro; and each of R3 and R4, independently, are hydrogen or C1-C6alkyl; by transfer hydrogenation of 10-oxo-dihydrodibenz[b,f]azepines; and to novel catalysts of formula (III?a) and (III?b) wherein M is Ru, Rh, Ir, Fe, Co or Ni; L1 is hydrogen; L2 represents an aryl or aryl-aliphatic residue; and the further radicals have the meanings as defined herein; and to new crystal forms of both enantiomers of 10,11-dihydro-10 hydroxy-5Hdibenz[b,f]azepine-5-carboxamide, obtainable by the new processes, their usage in the production of pharmaceutical preparations, new pharmaceutical preparations comprising these new crystal forms and/or the use of these new crystal forms in the treatment of disorders such as epilepsy, or in the production of pharmaceutical formulations which are suitable for this treatment.
    Type: Application
    Filed: October 6, 2003
    Publication date: June 29, 2006
    Inventors: Christian Mathes, Gottfried Sedelmeier, Fritz Blatter, Sabine Pfeffer, Dominique Grimler
  • Optical isomers of an iloperidone metabolite
    Publication number: 20050020632
    Abstract: The invention provides compounds of formulae (I) and (II), their preparation and their use as pharmaceuticals.
    Type: Application
    Filed: August 30, 2002
    Publication date: January 27, 2005
    Inventors: Dominique Grimler, Hans Kalkman, Hegun Yin