Abstract: A method of the bio-production of methionine and/or of its derivatives thereof from a reduced source of sulfur, such as MeSH or MeSNa including genetically modified yeasts, having an increased ability to produce methionine and/or its derivatives thereof, as compared to the parent yeasts.

Abstract: Metabolites produced by a microorganism using oxaloacetate, pyruvate and/or acetyl-CoA as substrate or co-substrate upstream in the biosynthesis pathway, and more particularly using oxaloacetate. There is indeed a need in the art for transformed, in particular recombinant, microorganisms having at least an increased ability to produce oxaloacetate, pyruvate and/or acetyl-CoA, and in particular oxaloacetate, thus allowing an increased capacity to produce metabolites produced using oxaloacetate, pyruvate and/or acetyl-CoA as substrate or co-substrate upstream in the biosynthesis pathway, and in particular amino acids and their derivatives thereof, fatty acids, derivatives from the mevalonate pathway (in particular farnesyl, squalene, lanosterol, cholesterol and derivatives, and dolichols), flavonoides and/or polyketides. The solution proposed is the use of a genetically modified yeast comprising many modifications as described in the present text.

Abstract: Methods for producing phloroglucinol as well as methods of using type III polyketide synthases as phloroglucinol synthases, in particular the type III polyketide synthases of algae, such as eukaryotic ochrophyte algae, are described herein. In addition, polypeptides that have phloroglucinol synthase activity, the isolated nucleic acid molecules encoding these type III polyketide synthases, and the vectors and the host cells comprising such nucleic acid molecules are also described.

Abstract: A recombinant yeast having a reduced pyruvate decarboxylase activity, in the génome of which has been inserted: —one or more nucleic acids encoding an acetolactate synthase or ALS, —one or more nucleic acids encoding an acetolactate decarboxylase or ALD, —one or more nucleic acids encoding a butancdiol dehydrogenase or BDH, and —one or more copies of a nucleic acids encoding a NADH oxidase or NOXE.

Abstract: A series of fused pentacyclic imidazole derivatives, being potent modulators of human TNFa activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders. In particular, the present invention is concerned with 6,7-dihydro-7,14-methanobenzimidazo[1,2-b][2,5]benzodiazocin-5(14H)-one derivatives and analogs thereof.

Abstract: A portable authentication system includes a security module, that may be a smart card, SIM (Subscriber Identity Module), USB controller with a secure chip, or similar module capable of storing one or more credentials, and an interface module such as a digital badge holder that is able to communicate with the security module, for instance by providing a smart card communication interface. The portable authentication system may be either a single integrated system or a dual system where the security module can be removed or disconnected from the interface system.

Abstract: An integrated security system which seamlessly assimilates with current generation logical security systems. The integrated security system incorporates a security controller having standard network interface capabilities including IEEE 802.x and takes advantage of the convenience and security offered by smart cards and related devices for both physical and logical security purposes. The invention is based on standard remote authentication dial-in service (RADIUS) protocols or TCP/IP using SSL, TLS, PCT or IPsec and stores a shared secret required by the secure communication protocols in a secure access module coupled to the security controller. The security controller is intended to be a networked client or embedded intelligent device controlled remotely by to an authentication server. In another embodiment of the invention one or more life cycle management transactions are performed with the secure access module.

Abstract: A T-piece preformer for forming a T-piece in a pipe-in-pipe (PIP) pipeline for a marine environment, the PIP pipeline has at least inner and outer pipes having an annular space thereinbetween, and one or more cables extending along the annular space. The T-piece preformer includes at least: (a) inner and outer longitudinal collars; (b) annular walls between the inner and outer collars; (c) cable apertures through each annular wall; and (d) one or more guide points on the outer collar radially offset from the or each cable apertures, to guidance for a hole into the T-piece performer. The T-piece preformer can be assembled into a PIP pipeline, and requires a final hole during laying. The T-piece preformer has cable apertures through each annular wall, for allowing continuation of cables in the annular space through the PIP pipeline and T-piece preformer, and the T-piece.

Abstract: The present invention relates to a recombinant yeast having a reduced pyruvate decarboxylase activity, in the genome of which has been inserted: —one or more nucleic acids encoding an acetolactate synthase or ALS, —one or more nucleic acids en coding an acetolactate decarboxylase or ALD, and—one or more copies of a nucleic acids encoding a NADH oxidase or NOXE.

Abstract: A portable authentication system includes a security module, that may be a smart card, SIM (Subscriber Identity Module), USB controller with a secure chip, or similar module capable of storing one or more credentials, and an interface module such as a digital badge holder that is able to communicate with the security module, for instance by providing a smart card communication interface. The portable authentication system may be either a single integrated system or a dual system where the security module can be removed or disconnected from the interface system.

Abstract: An integrated security system which seamlessly assimilates with current generation logical security systems. The integrated security system incorporates a security controller having standard network interface capabilities including IEEE 802.x and takes advantage of the convenience and security offered by smart cards and related devices for both physical and logical security purposes. The invention is based on standard remote authentication dial-in service (RADIUS) protocols or TCP/IP using SSL, TLS, PCT or IPsec and stores a shared secret required by the secure communication protocols in a secure access module coupled to the security controller. The security controller is intended to be a networked client or embedded intelligent device controlled remotely by to an authentication server. In another embodiment of the invention one or more life cycle management transactions are performed with the secure access module.

Abstract: A series of fused pentacyclic imidazole derivatives, being potent modulators of human TNFa activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders. In particular, the present invention is concerned with 6,7-dihydro-7,14-methanobenzimidazo[1,2-b][2,5]benzodiazocin-5(14H)-one derivatives and analogs thereof.

Abstract: A portable authentication system includes a security module, that may be a smart card, SIM (Subscriber Identity Module), USB controller with a secure chip, or similar module capable of storing one or more credentials, and an interface module such as a digital badge holder that is able to communicate with the security module, for instance by providing a smart card communication interface. The portable authentication system may be either a single integrated system or a dual system where the security module can be removed or disconnected from the interface system.

Abstract: An integrated security system which seamlessly assimilates with current generation logical security systems. The integrated security system incorporates a security controller having standard network interface capabilities including IEEE 802.x and takes advantage of the convenience and security offered by smart cards and related devices for both physical and logical security purposes. The invention is based on standard remote authentication dial-in service (RADIUS) protocols or TCP/IP using SSL, TLS, PCT or IPsec and stores a shared secret required by the secure communication protocols in a secure access module coupled to the security controller. The security controller is intended to be a networked client or embedded intelligent device controlled remotely by to an authentication server. In another embodiment of the invention one or more life cycle management transactions are performed with the secure access module.

Abstract: A series of fused tricyclic imidazole derivatives, in particular dihydro-1H-cyclopenta[4,5]imidazo[1,2-a]pyridine derivatives, and analogues thereof, being potent modulators of human TNF? activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders.

Abstract: An integrated security system which seamlessly assimilates with current generation logical security systems. The integrated security system incorporates a security controller having standard network interface capabilities including IEEE 802.x and takes advantage of the convenience and security offered by smart cards and related devices for both physical and logical security purposes. The invention is based on standard remote authentication dial-in service (RADIUS) protocols or TCP/IP using SSL, TLS, PCT or IPsec and stores a shared secret required by the secure communication protocols in a secure access module coupled to the security controller. The security controller is intended to be a networked client or embedded intelligent device controlled remotely by to an authentication server. In another embodiment of the invention one or more life cycle management transactions are performed with the secure access module.

Abstract: The present invention relates to the use of pteridines as inhibitors of HCV replication as well as their use in pharmaceutical compositions aimed to treat or combat HCV infections. In addition, the present invention relates to compounds per se and their use as medicines. The present invention also concerns processes for the preparation of such compounds, pharmaceutical compositions comprising them, and combinations of said compounds with other anti-HCV agents.

Abstract: A series of tricyclic benzimidazole derivatives, in particular dihydro-1H-imidazo [1,2-a]benzimidazole, dihydro-1H-pyrrolo [1,2-a]benzimidazole, dihydro-1H-pyrazino[1,2-a]benzimidazole, dihydro-1H-[1,4]oxazino[4,3-a]benzimidazole and dihydrothiazolo[3,4-a]benzimidazolem, and analogs thereof, being potent modulators of human TNFa activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders.

Abstract: An integrated security system which seamlessly assimilates with current generation logical security systems. The integrated security system incorporates a security controller having standard network interface capabilities including IEEE 802.x and takes advantage of the convenience and security offered by smart cards and related devices for both physical and logical security purposes. The invention is based on standard remote authentication dial-in service (RADIUS) protocols or TCP/IP using SSL, TLS, PCT or IPsec and stores a shared secret required by the secure communication protocols in a secure access module coupled to the security controller. The security controller is intended to be a networked client or embedded intelligent device controlled remotely by to an authentication server. In another embodiment of the invention one or more life cycle management transactions are performed with the secure access module.

Abstract: A series of substituted fused tricyclic imidazole derivatives, in particular dihydro-1H-pyrano[4?,3?:4,5]imidazo[1,2-a]pyridine, 1,2,3,4-tetrahydroimidazo[1,2-a:5,4-c?]dipyridine, dihydro-1H-pyrano[3?,4?:4,5]imidazo[1,2-a]pyridine and tetrahydro-6H-cyclohepta[4,5]imidazo[1,2-a]pyridine, and analogs thereof, being potent modulators of human TNF? activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders.