Patents by Inventor Dominique M. Missiakas

Dominique M. Missiakas has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and compositions involving protective staphylococcal antigens, such as EBH polypeptides
    Patent number: 8945588
    Abstract: The present invention concerns methods and compositions for treating or preventing a bacterial infection, particularly infection by a Staphylococcus bacterium. The invention provides methods and compositions for stimulating an immune response against the bacteria. In certain embodiments, the methods and compositions involve an Ebh antigen.
    Type: Grant
    Filed: May 7, 2012
    Date of Patent: February 3, 2015
    Assignee: The University of Chicago
    Inventors: Olaf Schneewind, Alice G. Cheng, Dominique M. Missiakas, Hwan Keun Kim
  • COMPOSITIONS AND METHODS RELATED TO PROTEIN A (SPA) ANTIBODIES AS AN ENHANCER OF IMMUNE RESPONSE
    Publication number: 20140335095
    Abstract: The present invention concerns methods and compositions for treating or preventing a bacterial infection, particularly infection by a Staphylococcus bacterium. The invention provides methods and compositions for stimulating an immune response against the bacteria. In certain embodiments, the methods and compositions involve a non-toxigenic Protein A (SpA) variant or an antibody directed thereto.
    Type: Application
    Filed: July 18, 2014
    Publication date: November 13, 2014
    Inventors: Olaf Schneewind, Alice Cheng, Dominique M. Missiakas, Hwan Keun Kim
  • IMMUNOGENIC PROTEIN CONJUGATES AND METHOD FOR MAKING AND USING THE SAME
    Publication number: 20140302084
    Abstract: Production of protein conjugate vaccines by use of transpeptidase enzymes, such as sortase enzymes. For example, homogenous immunoconjugates (e.g., a population of molecules having the same structure) formed by conjugating an antigenic polypeptide and a bacterial capsule component are provided. In certain aspects, methods for generating an immune response to B. anthracis by use of protective antigen-PDGA immunoconjugates are provided.
    Type: Application
    Filed: August 5, 2012
    Publication date: October 9, 2014
    Applicant: The University of Chicago
    Inventors: Olaf Schneewind, Dominique M. Missiakas, Yating Wang
  • Compositions and methods related to protein A (SpA) variants
    Patent number: 8821894
    Abstract: The present invention concerns methods and compositions for treating or preventing a bacterial infection, particularly infection by a Staphylococcus bacterium. The invention provides methods and compositions for stimulating an immune response against the bacteria. In certain embodiments, the methods and compositions involve a non-toxigenic Protein A (SpA) variant.
    Type: Grant
    Filed: July 1, 2011
    Date of Patent: September 2, 2014
    Assignee: The University of Chicago
    Inventors: Olaf Schneewind, Alice G. Cheng, Dominique M. Missiakas, Hwan Keun Kim
  • Compositions and methods related to protein A (SpA) antibodies as an enhancer of immune response
    Patent number: 8808699
    Abstract: The present invention concerns methods and compositions for treating or preventing a bacterial infection, particularly infection by a Staphylococcus bacterium. The invention provides methods and compositions for stimulating an immune response against the bacteria. In certain embodiments, the methods and compositions involve a non-toxigenic Protein A (SpA) variant or an antibody directed thereto.
    Type: Grant
    Filed: April 5, 2011
    Date of Patent: August 19, 2014
    Assignee: The University of Chicago
    Inventors: Olaf Schneewind, Alice Cheng, Dominique M. Missiakas, Hwan Keun Kim
  • COMPOSITIONS AND METHODS RELATED TO ANTIBODIES TO STAPHYLOCOCCAL PROTEIN A
    Publication number: 20140170134
    Abstract: Embodiments concern methods and compositions for treating or preventing a bacterial infection, particularly infection by a Staphylococcus bacterium. Aspects include methods and compositions for providing a passive immune response against the bacteria. In certain embodiments, the methods and compositions involve an antibody that binds Staphylococcal protein A (SpA).
    Type: Application
    Filed: August 15, 2012
    Publication date: June 19, 2014
    Applicant: The University of Chicago
    Inventors: Olaf Schneewind, Dominique M. Missiakas, Hwan Keun Kim, Carta Emolo, Andrea Dedent
  • COMPOSITIONS AND METHODS RELATED TO ATTENUATED STAPHYLOCOCCAL STRAINS
    Publication number: 20130236419
    Abstract: The present invention concerns methods and compositions for treating or preventing a bacterial infection, particularly infection by a Staphylococcus bacterium. The invention provides methods and compositions for stimulating an immune response against the bacteria. In certain embodiments, the methods and compositions involve attenuated S. aureus strains having deletions in their genome, such as in the srtA and saeR regions.
    Type: Application
    Filed: September 9, 2011
    Publication date: September 12, 2013
    Applicant: THE UNIVERSITY OF CHICAGO
    Inventors: Olaf Schneewind, Hye-Young Kim, Dominique M. Missiakas, Hwan Keun Kim
  • METHODS AND COMPOSITIONS INVOLVING PROTECTIVE STAPHYLOCOCCAL ANTIGENS
    Publication number: 20130230550
    Abstract: The present invention concerns methods and compositions for treating or preventing a bacterial infection, particularly infection by a Staphylococcus bacterium. The invention provides methods and compositions for stimulating an immune response against the bacteria. In certain embodiments, the methods and compositions involve a non-toxigenic Protein A (SpA) variant. In some embodiments, the methods and compositions involve SdrD, ClfA, and/or FnbpB polypeptides.
    Type: Application
    Filed: September 9, 2011
    Publication date: September 5, 2013
    Applicant: The University of Chicago
    Inventors: Olaf Schneewind, Alice G. Cheng, Dominique M. Missiakas, Hwan Keun Kim, Hye-Young Kim
  • COMPOSITIONS AND METHODS RELATED TO PROTEIN A (SpA) ANTIBODIES AS AN ENHANCER OF IMMUNE RESPONSE
    Publication number: 20130136746
    Abstract: The present invention concerns methods and compositions for treating or preventing a bacterial infection, particularly infection by a Staphylococcus bacterium. The invention provides methods and compositions for stimulating an immune response against the bacteria. In certain embodiments, the methods and compositions involve a non-toxigenic Protein A (SpA) variant or an antibody directed thereto.
    Type: Application
    Filed: April 5, 2011
    Publication date: May 30, 2013
    Applicant: The University of Chicago
    Inventors: Olaf Schneewind, Alice Cheng, Dominique M. Missiakas, Hwan Keun Kim
  • METHODS AND COMPOSITIONS INVOLVING PROTECTIVE STAPHYLOCOCCAL ANTIGENS, SUCH AS EBH POLYPEPTIDES
    Publication number: 20120282247
    Abstract: The present invention concerns methods and compositions for treating or preventing a bacterial infection, particularly infection by a Staphylococcus bacterium. The invention provides methods and compositions for stimulating an immune response against the bacteria. In certain embodiments, the methods and compositions involve an Ebh antigen.
    Type: Application
    Filed: May 7, 2012
    Publication date: November 8, 2012
    Inventors: Olaf Schneewind, Alice G. Cheng, Dominique M. Missiakas, Hwan Keun Kim
  • COMPOSITIONS AND METHODS RELATED TO PROTEIN A (SPA) VARIANTS
    Publication number: 20120114686
    Abstract: Disclosed are methods and compositions for treating or preventing a Staphylococcus bacterial infection using a non-toxigenic Protein A (SpA) variant.
    Type: Application
    Filed: April 5, 2010
    Publication date: May 10, 2012
    Applicant: UNIVERSITY OF CHICAGO
    Inventors: Olaf Schneewind, Alice Cheng, Dominique M. Missiakas, Hwan Keun Kim
  • Compositions and Methods Related to Bacterial EAP, EMP, and/or ADSA Proteins
    Publication number: 20110262477
    Abstract: The present invention concerns methods and compositions for treating or preventing a bacterial infection, particularly infection by a Staphylococcus bacterium. The invention provides methods and compositions for stimulating an immune response against the bacteria. In certain embodiments, the methods and compositions involve an Eap, Emp and/or AdsA amino acid sequence, or an agent that binds and inhibits the same.
    Type: Application
    Filed: October 6, 2009
    Publication date: October 27, 2011
    Applicant: UNIVERSITY OF CHICAGO
    Inventors: Alice Cheng, Vilasack Thammavongsa, Justin Kern, Dominique M. Missiakas, Olaf Schneewind