Abstract: In various embodiments a light emitting device is disclosed comprising a first and second source for emitting light with a first and a second spectral distribution, respectively, a first and second light guides comprising a first light input surface and a first light exit surface, respectively, the light input surface and the light exit surface of the respective light guide extending at an angle with respect to each other. The first and second light guide configured to convert a part of the received light to light with a third and fourth spectral distribution, respectively, and couple at least a part of the light with the third and fourth spectral distribution out of the first and second light exit surface, respectively. The light have the first and the second spectral distribution having different spectral distributions, and the light having the third and the fourth spectral distribution have different spectral distributions.

Abstract: A light emitting device (1) comprising a first light source (21) and a second light source (22), a luminescent element (4) comprising a first light input surface (41), a second light input surface (42), a light exit surface (43), a first further surface (44) and a second further surface (45), a first cooling assembly (5) and a second cooling assembly (6), the first cooling assembly (5) comprising a first cooling element (52) and a first light source board (51) on which one of the light sources is mounted, and the second cooling assembly (6) comprising a second cooling element (62) and a second light source board (61), on which the other one of the light sources is mounted, and the second cooling assembly (6) being arranged with a surface (621) in mechanical and thermal contact with the first further surface (44) of the luminescent element thereby forming a first interface and the first cooling assembly (5) being arranged with a surface (521) in mechanical and thermal contact with the second further surface (4

Abstract: A cartridge (110) and a method process target components (T1, T2) of a sample fluid, for example the detection of cardiac markers in blood. The cartridge (110) includes a reaction chamber (114) with a hydrophilic reaction surface (115). A physical barrier (116,118) on the reaction surface (115), for example a protrusion, at least partially borders an investigation region (117,117?) which includes capture probes (CP1, CP2) that specifically bind to target components (T1, T2) of the sample fluid.

Abstract: A sensing device (100) detects a target substance (2) in an investigation region (113). The sensing device (100) includes a sensing surface (112) with an investigation region (113) and a reference region (120). The sensing device (100) further includes a reference element (121) located at the reference region (120). The reference element (121) is adapted to shield the reference region (120) from the target substance (2) such that light reflected at the reference region (120) under total internal reflection conditions remains unaffected by the presence or absence of the target substance (2). This allows measuring a property, typically the intensity, of light reflected at the reference region (120) independent of the presence or absence of the target substance (2). This measured property of the reflected light can be used for performing a correction of light reflected at the investigation region (113).

Abstract: This disclosure provides a lighting device which comprises a support structure comprising a locking mechanism, a light source arranged in contact with the support structure, a wavelength converter configured to convert light from a first wavelength range to a second wavelength range, the wavelength converter having a light entrance surface configured to receive light and a light exit surface configured to emit light. The wavelength converter is releasably connected to the support structure in a locked position via said locking mechanism, and the light entrance surface is arranged in optical contact with the light source.

Abstract: A wavelength converting member is provided, comprising a sealed capsule at least partly made of sintered polycrystalline ceramic, for example sintered polycrystalline alumina, said capsule defining at least one sealed cavity; and—a wavelength converting material contained within said sealed cavity. The wavelength converting member has high total forward transmission of light, high thermal conductivity, high strength and provides excellent protection for the wavelength converting member against oxygen and water. The wavelength converting member can advantageously be applied in a light emitting arrangement or as a color wheel for a digital image projector.

Abstract: A microelectronic sensor device for the detection of target components with label or magnetic particles includes a carrier with a binding surface at which target components can collect and optionally bind to specific capture elements. An input light beam is transmitted into the carrier and totally internally reflected at the binding surface. The amount of light in the output light beam is detected by a light detector. Evanescent light generated during the total internal reflection is affected by target components and/or label particles at the binding surface and will be missing in the output light beam. This is used to determine the amount of target components at the binding surface from the amount of light in the output light beam. A magnetic field generator is optionally used to generate a magnetic field at the binding surface by which magnetic label particles can be manipulated, such as attracted or repelled.

Abstract: A lighting device (100) which comprises a support structure (102; 104) comprising a locking mechanism (114, 302, 304), a light source (106) arranged in contact with the support structure (102; 104), a wavelength converter (110) configured to convert light from a first wavelength range to a second wavelength range, the wavelength converter having a light entrance surface configured to receive light and a light exit surface configured to emit light. The wavelength converter (110) is releasably connected to the support structure (102; 104) in a locked position via said locking mechanism, and the light entrance surface is arranged in optical contact with the light source (106).

Abstract: In various embodiments a light emitting device is disclosed comprising a first and second source for emitting light with a first and a second spectral distribution, respectively, a first and second light guides comprising a first light input surface and a first light exit surface, respectively, the light input surface and the light exit surface of the respective light guide extending at an angle with respect to each other. The first and second light guide configured to convert a part of the received light to light with a third and fourth spectral distribution, respectively, and couple at least a part of the light with the third and fourth spectral distribution out of the first and second light exit surface, respectively. The light have the first and the second spectral distribution having different spectral distributions, and the light having the third and the fourth spectral distribution have different spectral distributions.

Abstract: A light source (104) arranged on a substrate (100) and having a light exit surface, a wavelength converter (106) configured to convert light from a first wavelength to a second wavelength, the wavelength converter (106) having a light exit surface (110) and a light entrance surface (114) and an optical coupling element (112), arranged between and in contact with the light exit surface of the light source (104) and the light entrance surface (114) of the wavelength converter (106), and configured to couple light from the light source (104) to the wavelength converter (106), wherein at least a major portion of the surface of the wavelength converter (106), other than the light exit surface (110) and the light entrance surface (114), has a surface roughness, RA, less than 100 nm.

Abstract: A light emitting device (102, 202) comprising a light source (104) having a light exit surface, a wavelength converter (106) configured to convert light from a first wavelength to a second wavelength, said wavelength converter having a light exit surface (110) and a light entrance surface, a heat sink (100) and an optical coupling element (112), arranged in thermal connection with said heat sink (100) and said wavelength converter (106), wherein said optical coupling element (112) is selected to have a refractive index lower than a refractive index of said wavelength converter (106). The optical coupling element (112) will allow for an efficient heat transfer from the wavelength converter (106) to the heat sink (100) while avoiding loss of light from unwanted surfaces.

Abstract: A wavelength converting member is provided, comprising a sealed capsule at least partly made of sintered polycrystalline ceramic, for example sintered polycrystalline alumina, said capsule defining at least one sealed cavity; and—a wavelength converting material contained within said sealed cavity. The wavelength converting member has high total forward transmission of light, high thermal conductivity, high strength and provides excellent protection for the wavelength converting member against oxygen and water. The wavelength converting member can advantageously be applied in a light emitting arrangement or as a color wheel for a digital image projector.

Abstract: The invention relates to a fluid providing apparatus (5; 34) for providing a fluid to an analyzing apparatus (17; 33) for analyzing the fluid and to the analyzing apparatus (17; 33). The fluid providing apparatus (34) comprises a casing (35), which has an introduction opening (7), through which a fluid transferring element (1) is introducible into the casing (35) for transferring the fluid to the fluid providing apparatus (34). The casing (35) comprises further a fluid releasing section (8) for releasing the fluid from the fluid transferring element (1) and a fluid transferring element detection section (36) for detecting whether the fluid transferring element (1) is introduced into the casing (35) by interacting with a fluid transferring element detection unit of the analyzing apparatus (17; 33).

Abstract: The invention relates to a method for the detection of target components that comprise label particles, for example magnetic particles (1). The method includes (a) collecting the target components at a binding surface (12, 112, 512) of a carrier (11, 111, 211, 311, 411, 511); (b) directing an input light beam (L1, L1a, L1b) into the carrier such that it is totally internally reflected in an investigation region (13, 313a, 313b) at the binding surface (12, 112, 512); and (c) determining the amount of light of an output light beam (L2, L2a, L2b) that comprises at least some of the totally internally reflected light. Evanescent light generated during the total internal reflection is affected (absorbed, scattered) by target components and/or label particles (1) at the binding surface (12) and will therefore be missing in the output light beam (L2). This can be used to determine the amount of target components at the binding surface (12) from the amount of light in the output light beam (L2, L2a, L2b).

Abstract: The invention relates to a carrier with a binding surface at which target components that comprise label particles, for example magnetic particles, can collect and optionally bind to specific capture elements. An input light beam (L1) is transmitted into the carrier and totally internally reflected at the binding surface. The amount of light in the output light beam (L2) and optionally also of fluorescence light emitted by target components at the binding surface is then detected by a light detector. Evanescent light generated during the total internal reflection is affected (absorbed, scattered) by target components and/or label particles at the binding surface and will therefore be missing in the output light beam (L2). This can be used to determine the amount of target components at the binding surface from the amount of light in the output light beam (L2, L2a, L2b).

Abstract: The invention relates to a cartridge (110) and a method for the processing of target components (T1, T2) of a sample fluid, for example the detection of cardiac markers in blood. The cartridge (110) comprises a reaction chamber (114) with a hydrophilic reaction surface (115). A physical barrier (116,118) on the reaction surface (115), for example a protrusion, at least partially borders an investigation region (117,117?) which comprises capture probes (CP1, CP2) that specifically bind to target components (T1, T2) of the sample fluid.

Abstract: The invention relates to focusing optics (100) for a biosensor (10) which allow with simple means to accurately image an extended investigation region (13) onto a detector plane (P). To this end, the focusing optics (100) comprises at least two focusing lenslets (LL) that are arranged adjacent to each other such that they image an incident parallel light beam (L2) that is directed along a main optical axis (MOA) onto a common plane (P). The output light beam (L2) that is received by the focusing optics (100) may preferably originate from total internal reflection of a parallel input light beam (L1) at the investigation region (13) of a transparent carrier.

Abstract: A carrier and an apparatus for optical detection of a sample in a sample chamber includes en optical structure for refracting an input light beam into the adjacent sample chamber and for collecting an output light beam from light that originates in the sample chamber from the input light beam. The optical structure includes grooves in the surface of the carrier in which the Input light beam is transmitted Over a short distance through a sample. The optical structure can also be used for a wetting detection.

Abstract: The invention relates to a microelectronic sensor device for the examination of target particles (1) that are bound to binding sites (3) at the binding surface (12) of a carrier (11). In a preferred embodiment, an input light beam (L1) is transmitted into the carrier (11), where a frustrated total internal reflection (FTIR) takes place at the binding surface (12). The amount of light in a resulting output light beam (L2) is detected by a light detector (31) and provides information about the presence of target particles at the binding surface. Moreover, an actuation unit (50) induces movements of the bound target particles (1) by an interaction with a magnetic field (B) or an electric field, particularly with a given modulation frequency (COIn), such that by a demodulation of the detector signal (S) effects of the target particles can be distinguished from background.

Abstract: The present invention provides an FTIR system comprising a first light source emitting light of a first wavelength, a sample volume with an adjacent sensor surface, a detector for detecting light reflected at said sensor surface. The sensor surface is illuminated by said first light source fulfilling the condition of total internal reflection and generating an evanescent field with a decay length within the sample volume. The system further comprises means for changing the decay length of the evanescent field and means for correlating the detected signals with the change of the decay length of the evanescent field.