Patents by Inventor Dominique Michaud

Dominique Michaud has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11959088
    Abstract: A method for synthesizing a protein of interest within a plant or a portion of a plant is provided. The method involves treating the plant to increase secondary leaf biomass production, followed by introducing one or more than one nucleic acid sequence encoding a protein of interest operatively linked with a regulatory region that is active in the plant, into the plant. The plant is then maintained under conditions that permit the nucleic acid sequence encoding the protein of interest to be expressed in the plant or the portion of the plant. Optionally, the plant or portion of the plant may be harvested and the protein of interest extracted.
    Type: Grant
    Filed: July 10, 2015
    Date of Patent: April 16, 2024
    Assignees: ARAMIS BIOTECHNOLOGIES INC., UNIVERSITE LAVAL
    Inventors: Dominique Michaud, Steeve Pepin, Gilbert Ethier, Marie-Claire Goulet, Linda Gaudreau, Marielle Gagne, Michele Martel, Nicole Bechtold, Marc-Andre D'Aoust, Andre Gosselin
  • Patent number: 11390878
    Abstract: A method of increasing the yield, stability, or both of an acid sensitive protein in a plant is provided. The method comprises introducing a first nucleic acid and a second nucleic acid into the plant, or portion of the plant. The first nucleic acid comprises a first regulatory region active in the plant and operatively linked to a nucleotide sequence encoding the acid sensitive protein. The second nucleic acid comprises a second regulatory region active in the plant and operatively linked to a nucleotide sequence encoding a channel protein, for example but not limited to a proton channel protein. The plant or portion of the plant is incubated under conditions that permit the expression of the nucleic acids, thereby increasing the yield of the acid sensitive protein when compared to the yield of the acid sensitive protein produced in the plant or portion of the plant produced under the same conditions, and in the absence of the proton channel protein.
    Type: Grant
    Filed: January 26, 2015
    Date of Patent: July 19, 2022
    Assignees: MEDICAGO INC., UNIVERSITE LAVAL
    Inventors: Marc-Andre D'Aoust, Manon Couture, Louis-Philippe Vezina, Dominique Michaud, Philippe Varennes-Jutras, Frank Sainsbury
  • Patent number: 10907168
    Abstract: A method of increasing expression of an heterologous protein of interest in a plant or portion of the plant is provided. The method comprises treating the plant or portion of the plant with a jasmonate-pathway activator, and introducing a nucleotide sequence operably linked to a regulatory region derived from a DNA plant virus and encoding the heterologous protein of interest into the plant or portion of the plant. Alternatively, the plant or plant portion may comprise the nucleic acid and encoding the heterologous protein of interest, and the plant or portion of the plant is treated with the jasmonate pathway activator. The treated plant is incubated under conditions to permit expression of the nucleotide sequence encoding the heterologous protein of interest.
    Type: Grant
    Filed: June 30, 2016
    Date of Patent: February 2, 2021
    Assignees: MEDICAGO INC., UNIVERSITE LAVAL
    Inventors: Marc-Andre D'Aoust, Stephanie Robert, Marie-Claire Goulet, Dominique Michaud, Frank Sainsbury
  • Publication number: 20180195078
    Abstract: A method of increasing expression of an heterologous protein of interest in a plant or portion of the plant is provided. The method comprises treating the plant or portion of the plant with a jasmonate-pathway activator, and introducing a nucleotide sequence operably linked to a regulatory region derived from a DNA plant virus and encoding the heterologous protein of interest into the plant or portion of the plant. Alternatively, the plant or plant portion may comprise the nucleic acid and encoding the heterologous protein of interest, and the plant or portion of the plant is treated with the jasmonate pathway activator. The treated plant is incubated under conditions to permit expression of the nucleotide sequence encoding the heterologous protein of interest.
    Type: Application
    Filed: June 30, 2016
    Publication date: July 12, 2018
    Inventors: Marc-Andre D'AOUST, Stephanie ROBERT, Marie-Claire GOULET, Dominique MICHAUD, Frank SAINSBURY
  • Publication number: 20170204427
    Abstract: A method for synthesizing a protein of interest within a plant or a portion of a plant is provided. The method involves treating the plant to increase secondary leaf biomass production, followed by introducing one or more than one nucleic acid sequence encoding a protein of interest operatively linked with a regulatory region that is active in the plant, into the plant. The plant is then maintained under conditions that permit the nucleic acid sequence encoding the protein of interest to be expressed in the plant or the portion of the plant. Optionally, the plant or portion of the plant may be harvested and the protein of interest extracted.
    Type: Application
    Filed: July 10, 2015
    Publication date: July 20, 2017
    Inventors: Dominique MICHAUD, Steeve PEPIN, Gilbert ETHIER, Marie-Claire GOULET, Linda GAUDREAU, Marielle GAGNE, Michele MARTEL, Nicole BECHTOLD, Marc-Andre D'AOUST, Andre GOSSELIN
  • Patent number: 7665987
    Abstract: Burner for gas oven comprising a device for retaining a flame of the burner, separating the flame from a mixing chamber capable of receiving a flow of primary air and gas to form a gaseous mixture. The flame retention device is provided with a mesh comprising metal threads, capable of allowing said gaseous mixture to pass through the mesh, said mesh comprising at least one main zone and a pilot zone which are adjacent. The pilot zone having, according to a main direction of the flame of the burner, a thickness greater than the thickness of the main zone, capable of slowing down the gaseous mixture passing through the pilot zone relative to the mixture passing through the main zone. The burner comprises at least one orifice capable of receiving a secondary air flow.
    Type: Grant
    Filed: April 6, 2007
    Date of Patent: February 23, 2010
    Assignee: Thirode Grandes Cuisines Poligny
    Inventors: Christophe Leclerc, Gilbert Cornu, Dominique Michaud
  • Publication number: 20080318174
    Abstract: Burner for gas oven comprising a device for retaining a flame of the burner, separating the flame from a mixing chamber capable of receiving a flow of primary air and gas to form a gaseous mixture. The flame retention device is provided with a mesh comprising metal threads, capable of allowing said gaseous mixture to pass through the mesh, said mesh comprising at least one main zone and a pilot zone which are adjacent. The pilot zone having, according to a main direction of the flame of the burner, a thickness greater than the thickness of the main zone, capable of slowing down the gaseous mixture passing through the pilot zone relative to the mixture passing through the main zone. The burner comprises at least one orifice capable of receiving a secondary air flow.
    Type: Application
    Filed: April 6, 2007
    Publication date: December 25, 2008
    Inventors: Christophe Leclerc, Gilbert Cornu, Dominique Michaud
  • Publication number: 20060156440
    Abstract: The present invention relates to a method for increasing the stability of endogenous proteins recovered from plant cells or plants. The preservation of endogenous proteins integrity of endogenous protein occurs by neutralizing proteolysis in crude extracts, particularly by the use of genetic alteration of plant cells or plants that express recombinant protease inhibitors or altered activity of specific target proteases.
    Type: Application
    Filed: July 29, 2003
    Publication date: July 13, 2006
    Applicant: UNIVERSITE LAVAL
    Inventors: Dominique Michaud, Daniel Rivard, Raphael Anguenot, Sonia Trepanier, Louis-Philippe Vezina, France Brunelle
  • Publication number: 20050251885
    Abstract: The present invention relates to a method for enhancing the yield of recombinant protein produced in genetically transformed plants. The invention most particularly relates to a method for preventing the undesirable proteolysis of recombinant proteins after harvest of the plant, during processing of the products from the plants. Especially, this invention focuses on introducing protease inhibitors in plants to prevent undesirable proteolysis of recombinant proteins at the time of cell disruption during the extraction process.
    Type: Application
    Filed: July 28, 2003
    Publication date: November 10, 2005
    Applicant: UNIVERSITE LAVAL
    Inventors: Dominique Michaud, Daniel Rivard, Raphael Anguenot, Sonia Trepanier, Louis-Philippe Vezina, France Brunelle
  • Publication number: 20050055746
    Abstract: The invention relates to a method for the production of plants with increased protein content in leaves, by means of introduction of recombinant DNA molecules. Said recombinant DNA molecules are introduced into the plant, by means of a transformation system and comprise a DNA sequence of plant origin, expressed in plants, the genetic product of which inhibits a protein in leaves with the enzymatic activity of an aspartate protease and/or a serene protease. The plants which displays an increased content in leaf protein are chosen.
    Type: Application
    Filed: December 19, 2003
    Publication date: March 10, 2005
    Applicant: Universite Laval
    Inventors: Dominique Michaud, Raphael Anguenot, France Brunelle