Patents by Inventor Dominique Michel St Picq

Dominique Michel St Picq has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the obtention of a biological adhesive made of concentrated coagulation factors by "salting-out"
    Patent number: 5395923
    Abstract: The present invention relates to a process of making a concentrate of coagulation proteins starting with whole human or animal plasma. This concentrate is used as a biological adhesive when extemporaneously mixed to thrombin. The concentrated proteins include mostly fibrinogen, fibrin stabilizing factor (factor XIII) and fibronectin. The claimed process has the advantage of being short of execution while providing an excellent yield of coagulable proteins. No protease inhibitor has to be added during the process. The process involves steps of separation by "salting-out" in presence of amino-6 hexanoic acid which prevents co-precipitation of plasminogen with the desired coagulable proteins. The proteins so obtained are very stable after reconstitution in water for at least 24 hours at room or body temperature. After mixing with thrombin and calcium, the adhesive shows excellent strength and biocompatibility.
    Type: Grant
    Filed: February 23, 1993
    Date of Patent: March 7, 1995
    Assignee: Haemacure-Biotech, Inc.
    Inventors: Trung Bui-Khac, Lise Lavoie, Dominique Michel St Picq