Abstract: Provided is a process for the preparation of enantiomerically pure 1-substituted-3-aminoalcohols, particularly of (S)-(?)- and (R)-(+)-3-N-methylamino-1-(2-thienyl)-1-propanol, by asymmetrically hydrogenating salts of a carboxylic acids with an aminoketone of formula (II), wherein R1 is selected from the group consisting of 2-thienyl, 2-furanyl and phenyl, each optionally substituted with one or more halogen atoms and/or one or more C1-4-alkoxy groups, and wherein R2 is C1-4-alkyl or phenyl, each optionally substituted with one or more halogen atoms and/or one or more C1-4-alkyl or C1-4-alkoxy groups, and wherein the corresponding aminoalcohols are obtained by subsequent hydrolysis of their salts. Furthermore provided are salts of a carboxylic acid with said aminoketones and the aminoalcohols obtained by asymmetrically hydrogenating said aminoketones, respectively.

Abstract: Provided is a process for the preparation of enantiomerically pure 1-substituted-3-aminoalcohols, particularly of (S)-(?)- and (R)-(+)-3-N-methylamino-1-(2-thienyl)-1-propanol, by asymmetrically hydrogenating salts of a carboxylic acids with an aminoketone of formula (II), wherein R1 is selected from the group consisting of 2-thienyl, 2-furanyl and phenyl, each optionally substituted with one or more halogen atoms and/or one or more C1-4-alkoxy groups, and wherein R2 is C1-4-alkyl or phenyl, each optionally substituted with one or more halogen atoms and/or one or more C1-4-alkyl or C1-4-alkoxy groups, and wherein the corresponding aminoalcohols are obtained by subsequent hydrolysis of their salts. Furthermore provided are salts of a carboxylic acid with said aminoketones and the aminoalcohols obtained by asymmetriacally hydrogenating said aminoketones, respectively.

Abstract: A process for the preparation of enantiomerically pure 1-substituted-3-amino-alcohols, particularly of (S)-(?)- and (R)-(+)-3-N-methylamino-1-(2-thienyl)-1-propanol, by asymmetrically hydrogenating salts of a carboxylic acids with an aminoketone of the formula: wherein R1 is 2-thienyl, 2-furanyl or phenyl, each optionally substituted with one or more halogen atoms and/or one or more C1-4-alkyl or C1-4-alkoxy groups, and wherein R2 is C1-4-alkyl or phenyl, each optionally substituted with one or more halogen atoms and/or one or more C1-4-alkyl or C1-4-alkoxy groups. The corresponding aminoalcohols are obtained by subsequent hydrolysis of their salts. Salts of a carboxylic acid with the aminoketones and the aminoalcohols obtained by asymmetrically hydrogenating the aminoketones, respectively.

Abstract: An improved arrangement for a transverse dividing element includes an upper cross beam (32), each free end of the cross beam being guided longitudinally by way of an associated guiding structure. The guiding structure includes a slide having a groove in which a free end (34) of the cross beam (32) can slide longitudinally, the free end being equipped with guiding (92, 100) and a locking (102, 104) element. The transverse dividing element can be used to guide an upper cross beam supporting a transverse element that is used to divide the internal space of an aircraft cabin.

Abstract: A process is disclosed for the preparation of a compound of formula and/or an addition salt of a proton acid, wherein R1 and R2 independently represent alkyl, cycloalkyl, aryl or aralkyl, each aryl or aralkyl being optionally further substituted with alkyl, alkoxy and/or halogen. The process involves reacting a mixture comprising a methyl ketone of formula and a compound of formula H2N—R2 (V) and/or an addition salt of proton acid, and formaldehyde in the presence of a solvent selected from the group consisting of water, aliphatic alcohols, cycloaliphatic alcohols and mixtures thereof, and optionally a proton acid to afford a ?-amino ketone of formula and/or an addition salt of a proton acid, and reducing the carbonyl group of said ?-amino ketone to afford a compound of formula I, and/or an addition salt of a proton acid wherein the first step is carried out at a pressure above 1.5 bar.

Abstract: The present invention relates to a process for the preparation of organic nitrates having at least one nitryloxy and at least one hydroxy group, wherein the at least one hydroxy group may be present in form of an esterified hydroxy residue, the latter being esterified with an acid other than nitric acid.

Abstract: A process for the preparation of a compound of formula: and/or an addition salt of a proton acid, which process comprises the following steps: (a) reacting a mixture comprising (i) a methyl ketone of formula IV and (ii) a compound of formula: H2N—R2??V and/or an addition salt of proton acid, and (iii) formaldehyde or a source of formaldehyde, in the presence of a solvent, and optionally a proton acid, to afford a ?-amino ketone of formula II, and/or an addition salt of a proton acid, and (b) reducing the carbonyl group of said ?-amino acid, the first step is carried out at a pressure above 1.5 bar.

Abstract: A process for the preparation of N-monosubstituted ?-aminoalcohol sulfonates of formula (Ia), (Ib): wherein R1 is C6-20-aryl or C4-12-heteroaryl, each optionally being substituted with one or more halogen atoms and/or one or more C1-4-alkyl or C1-4-alkoxy groups, R2 is C1-4-alkyl or C6-20-aryl, each aryl optionally being substituted with one or more halogen atoms and/or one or more C1-4-alkyl or C1-4-alkoxy groups and wherein R3 is selected from the group consisting of C1-18-alkyl, C6-20-cycloalkyl, C6-20-aryl and C7-20-aralkyl residues. The process has the steps of (a) reacting a methyl ketone, a primary amine, formaldehyde and a sulfonic acid, at a pressure above 1.5 bar, optionally in a organic solvent, the organic solvent optionally containing water, to afford N-monosubstituted ?-aminoketone sulfonates of formula (II): wherein R1, R2 and R3 are as defined above, and (b) asymmetrically hydrogenating.

Abstract: The invention relates to an assembly of the type that comprises a guiding slide (36) consisting of a groove (40) having an inner wall which defines longitudinal guiding and/or rolling channels for complementary elements (92) borne by a guiding and/or rolling carriage (34) which is connected to a sub-assembly. The invention is characterised in that the inner wall of the groove (40) comprises at least one longitudinal electrical strip conductor (180) with which electrical contact means (190) can co-operate, said electrical contact means being borne by the guiding carriage (34) and being electrically connected to at least one associated electrical and/or electronic component of the sub-assembly. The invention can be used to guide an upper cross beam supporting a transverse element that is used to divide the internal space of an aircraft cabin.

Abstract: An improved arrangement for a transverse dividing element includes an upper cross beam (32), each free end of the cross beam being guided longitudinally by way of an associated guiding structure. The guiding structure includes a slide having a groove in which a free end (34) of the cross beam (32) can slide longitudinally, the free end being equipped with guiding (92, 100) and a locking (102, 104) element. The transverse dividing element can be used to guide an upper cross beam supporting a transverse element that is used to divide the internal space of an aircraft cabin.

Abstract: A process for the preparation of enantiomerically pure 1-substituted-3-amino-alcohols, particularly of (S)-(?)- and (R)-(+)-3-N-methylamino-1-(2-thienyl)-1-propanol, by asymmetrically hydrogenating salts of a carboxylic acids with an aminoketone of the formula: wherein R1 is 2-thienyl, 2-furanyl or phenyl, each optionally substituted with one or more halogen atoms and/or one or more C1-4-alkyl or C1-4-alkoxy groups, and wherein R2 is C1-4-alkyl or phenyl, each optionally substituted with one or more halogen atoms and/or one or more C1-4-alkyl or C1-4-alkoxy groups. The corresponding aminoalcohols are obtained by subsequent hydrolysis of their salts. Salts of a carboxylic acid with the aminoketones and the aminoalcohols obtained by asymmetrically hydrogenating the aminoketones, respectively.

Abstract: A process for the preparation of a compound of formula: and/or an addition salt of a proton acid, wherein R1 and R2 independently represent alkyl, cycloalkyl, aryl or aralkyl, each aryl or aralkyl being optionally further substituted with alkyl, alkoxy and/or halogen.

Abstract: A rotor assembly for a gas turbine engine, the rotor assembly comprises a plurality of cooling air deflectors made integral with the rotor disk to redirect air to a manifold at a bottom side of a corresponding blade retention slot on the periphery of the rotor disk.

Abstract: A rotor assembly for a gas turbine engine, the rotor assembly comprises a plurality of cooling air deflectors mounted on the rotor assembly to redirect air to a manifold at a bottom side of a corresponding blade retention slot on the periphery of the rotor disk.

Abstract: A process for the preparation of a compound of formula and/or an addition salt of a proton acid, wherein R1 and R2 independently represent alkyl, cycloalkyl, aryl or aralkyl, each aryl or aralkyl being optionally further substituted with alkyl, alkoxy and/or halogen, which process comprises the following steps: (a) reacting a mixture comprising (i) a methyl ketone of formula wherein R1 is as defined above, and (ii) a compound of formula H2N—R2 ??(V) and/or an addition salt of proton acid, wherein R2 is as defined above, and (iii) formaldehyde or a source of formaldehyde selected from the group consisting of formaldehyde in aqueous solution, 1,3,5-trioxane, paraformaldehyde and mixtures thereof, in the presence of a solvent selected from the group consisting of water, aliphatic alcohols, cycloaliphatic alcohols and mixtures thereof, and optionally a proton acid to afford a ?-amino ketone of formula and/or an addition salt of a proton acid, and (b) reducing the carbonyl group of said ?-amino

Abstract: A system converting seats into couches, characterized in that it comprises—with at least one set of seats (1, 2) comprising at least one base (d) and one backrest (f) connected by a linkage (e) allowing to move said seat into the seating mode, the base and the backrest assuming a first relative angular position or into the couch mode, the base and the backrest then assuming a second relative angular position—a support (3) for said seats, a conversion mechanism driving each linkage of each seat to convert each seat (1, 2) into a couch in such manner that at least two consecutive seats within a column of the set of seats shall be moved from the seating mode one behind the other into the couch mode one above the other.

Abstract: The movable class-partitioning divider for an illustrative airliner passenger cabin comprises in particular: a device to lock said divider into a mooring adapter selected during the translation of the divider along a guide rail configured longitudinally in said cabin and unlocking it before such translation takes place; a device connecting at least one first connector, which is firmly affixed to a movable support mounted on a longitudinal rail solidly joined to the cabin, to a second connector solidly which is firmly affixed to said mooring adapter; a device operating said locking and connecting devices during translational operation; a device to preclude actuating said operating devices as long as at least the first connector is outside a given connection zone to said second connector firmly affixed to said mooring adapter. Application: passenger transportation.

Abstract: The present invention relates to an orally administrable galenic formulation allowing improved absorption by the transmembrane or paracellular route in the gastrointestinal tract of active ingredients which are hydrophilic or ionizable in physiological media. The galenic formulation comprises at least one active ingredient, an absorption-promoting agent, and one or more pharmaceutically acceptable excipients.

Abstract: A disclosed method for transforming data from client-server request/response cycle includes receiving session-level semantic events. The session-level semantic events are mapped to accumulation containers based on a policy, for instance, based on a session identifier. The session level semantic events are examined for a type. From the type, the session level semantic events are mapped to one or more rules which perform aggregations, accumulations, or other operations based on the data from the session level semantic events. The rules perform these aggregations, accumulations, or other operations over a set of session level semantic events for generating information (termed “enterprise facts”) that are independent of the client-server protocol and have an meaning in context that spans more than the request/response cycle. Enterprise facts are generated when an session level semantic event that is a triggering condition for an action is received.

Abstract: The present invention relates to an orally administrable galenic form allowing improved absorption by the transmembrane or paracellular route in the gastrointestinal tract of active ingredients which are hydrophilic or ionizable in physiol. media, comprising at least one such active ingredient, an absorption-promoting agent having an HLB>8, the the absorption-promoting agent consisting of one or more lipid substances chosen from: polysorbates; polyoxyethylene ethers; esters of polyoxyethylene and fatty acids; fatty acids; fatty alcs.; bile acids and their salts with pharmaceutically acceptable cations; esters of C1-C6 alkanol with fatty acids; esters of polyol with fatty acids, the polyol comprising from 2 to 6 hydroxyl functional groups; and polyglycolyzed glycerides; in combination with one or more pharmaceutically acceptable excipients, the pharmaceutical forms comprising captopril being excluded. A controlled-release tablet contained (1) cores contg.