Patents by Inventor Dominique Roberge

Dominique Roberge has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10626120
    Abstract: The present disclosure relates to N-demethylation of a compound containing a tertiary N-methylamine, including for example a morphinan alkaloid, in a continuous flow system. In particular, the present disclosure relates to N-demethylation of oxymorphone-3,14-diacetate or 14-hydroxymorphinone-3,14-diacetate using highly active catalytic palladium (0) in a continuous flow system under elevated temperature and pressure condition. The methodology can be utilized towards the synthesis of noroxymorphone via aerobic palladium-catalyzed continuous flow N-demethylation.
    Type: Grant
    Filed: April 21, 2017
    Date of Patent: April 21, 2020
    Assignee: Noramco, LLC
    Inventors: Dominique Roberge, Petteri Elsner, Christian Oliver Kappe, Bernhard Gutmann, Ulrich Weigl, Douglas Phillip Cox
  • Publication number: 20190330221
    Abstract: The present disclosure relates to N-demethylation of a compound containing a tertiary N-methylamine, including for example a morphinan alkaloid, in a continuous flow system. In particular, the present disclosure relates to N-demethylation of oxymorphone-3,14-diacetate or 14-hydroxymorphinone-3,14-diacetate using highly active catalytic palladium (0) in a continuous flow system under elevated temperature and pressure condition. The methodology can be utilized towards the synthesis of noroxymorphone via aerobic palladium-catalyzed continuous flow N-demethylation.
    Type: Application
    Filed: April 21, 2017
    Publication date: October 31, 2019
    Inventors: Dominique Roberge, Petteri Elsner, Christian Oliver Kappe, Bernhard Gutmann, Ulrich Weigl, Douglas Phillip Cox
  • Patent number: 10058840
    Abstract: A method for preventing plugging of a continuous-reaction channel-system caused by a by-product of a continuous-reaction being carried out in said channel-system comprises the step of generating at least one ultrasonic wave travelling through said channel-system by coupling in a flow direction of at least one process fluid of a plurality of process fluids said at least one ultrasonic wave into said at least one process fluid.
    Type: Grant
    Filed: August 26, 2010
    Date of Patent: August 28, 2018
    Assignee: LONZA LTD.
    Inventors: Dominique Roberge, Fabio Rainone, Wilhelm Quittmann, Michael Gottsponer, Markus Eyholzer
  • Patent number: 9962678
    Abstract: A micro-reactor system assembly comprises a stack of at least n process modules (1-6), wherein n is an integer equal to or greater than 1, made from a rigid first material and comprising at least one reactive fluid passage (1A, 1B, 2A, 3A, 6A) for accommodating and guiding a reactive fluid, and at least n+1 heat exchange modules (7, 8) made from a ductile second material other than said first material and comprising at least one heat exchange fluid passage (7A, 8A) for accommodating and guiding a heat exchange fluid, wherein each process module (1-6) is sandwiched between two adjacent heat exchange modules (7, 8).
    Type: Grant
    Filed: June 28, 2016
    Date of Patent: May 8, 2018
    Assignee: LONZA AG
    Inventors: Dominique Roberge, Nikolaus Bieler, Bertin Zimmermann, Rainald Forbert
  • Publication number: 20170326520
    Abstract: A fluid mixing structure (10) for mixing at least two fluidic components has a flow inlet port and a flow outlet port and comprises a contraction zone (12), an expansion zone (14), and a retention zone (16), arranged in this order in an inflow direction (IFD) of a fluid flow to flow through said fluid mixing structure (10) and being composed of said at least two fluidic components, and a flow splitter (32) arranged In a space (30) formed by said expansion zone (14) and said retention zone (16) to split said fluid flow in a first sub fluid flow and a second sub fluid flow flowing in a first flow path and a second flow path, respectively, formed in the fluid mixing structure, and to mix said first and second sub fluid flows within said space (30) to generate and discharge a homogenized fluid flow, wherein said flow splitter (32) is arranged and configured to let any flow element of each of said first and second sub fluid flows prior to their mixing have a non-zero average flow component in said inflow direction
    Type: Application
    Filed: December 9, 2015
    Publication date: November 16, 2017
    Inventors: Dominique ROBERGE, Patrick PLOUFFE, Arturo MACCHI
  • Patent number: 9546136
    Abstract: The invention relates to a method for the preparation of imidodisulfuryl compounds in a continuous reaction at elevated temperatures.
    Type: Grant
    Filed: July 10, 2014
    Date of Patent: January 17, 2017
    Assignee: Lonza Ltd
    Inventors: Christian Schnider, Dominique Roberge, Michael Gottsponer, Andreas Klein, Thomas Gruetzner, Michael Bittel, Stefan Tille, Anna-Christina Hormes, Janine Leiggener
  • Publication number: 20160303537
    Abstract: A micro-reactor system assembly comprises a stack of at least n process modules (1-6), wherein n is an integer equal to or greater than 1, made from a rigid first material and comprising at least one reactive fluid passage (1A, 1B, 2A, 3A, 6A) for accommodating and guiding a reactive fluid, and at least n+1 heat exchange modules (7, 8) made from a ductile second material other than said first material and comprising at least one heat exchange fluid passage (7A, 8A) for accommodating and guiding a heat exchange fluid, wherein each process module (1-6) is sandwiched between two adjacent heat exchange modules (7, 8).
    Type: Application
    Filed: June 28, 2016
    Publication date: October 20, 2016
    Inventors: Dominique Roberge, Nikolaus Bieler, Bertin Zimmermann, Rainald Forbert
  • Publication number: 20160289177
    Abstract: The invention relates to a method for the preparation of imidodisulfuryl compounds in a continuous reaction at elevated temperatures.
    Type: Application
    Filed: July 10, 2014
    Publication date: October 6, 2016
    Inventors: Christian Schnider, Dominique Roberge, Michael Gottsponer, Andreas Klein, Thomas Gruetzner, Michael Bittel, Stefan Tille, Anna-Christina Hormes, Janine Leiggener
  • Patent number: 9375698
    Abstract: A micro-reactor system assembly comprises a stack of at least n process modules (1-6), wherein n is an integer equal to or greater than 1, made from a rigid first material and comprising at least one reactive fluid passage (1A, 1B, 2A, 3A, 6A) for accommodating and guiding a reactive fluid, and at least n+1 heat exchange modules (7, 8) made from a ductile second material other than said first material and comprising at least one heat exchange fluid passage (7A, 8A) for accommodating and guiding a heat exchange fluid, wherein each process module (1-6) is sandwiched between two adjacent heat exchange modules (7, 8).
    Type: Grant
    Filed: July 14, 2014
    Date of Patent: June 28, 2016
    Assignee: Lonza AG
    Inventors: Dominique Roberge, Nikolaus Bieler, Bertin Zimmermann, Rainald Forbert
  • Publication number: 20150158007
    Abstract: A method for preventing plugging of a continuous-reaction channel-system caused by a by-product of a continuous-reaction being carried out in said channel-system comprises the step of generating at least one ultrasonic wave travelling through said channel-system by coupling in a flow direction of at least one process fluid of a plurality of process fluids said at least one ultrasonic wave into said at least one process fluid.
    Type: Application
    Filed: August 26, 2010
    Publication date: June 11, 2015
    Inventors: Dominique Roberge, Fabio Rainone, Wilhelm Quittmann, Michael Gottsponer, Markus Eyholzer
  • Patent number: 9023296
    Abstract: A method of manufacturing a target reactor having a flow-channel system in which a plurality of reactants continuously flowing into said target reactor are mixed and interconvert to form a target volumetric flow-rate (f2) of a product continuously flowing out of said target reactor, wherein the smallest hydraulic diameter (dh2) of said target reactor is calculated based on the relationship d h ? ? 2 = d h ? ? 1 ? ( f 2 f 1 ) 3 - n 7 - n in a turbulent or transitional turbulent flow, wherein n is a non-integer number with 1>n?0, between the corresponding smallest hydraulic diameter (dh1) of a standard reactor having the same fluidic type of flow-channel system, f1 is a standard volumetric flow-rate of said standard reactor carrying out the same interconversion, and f2 is said target volumetric flow-rate.
    Type: Grant
    Filed: May 12, 2010
    Date of Patent: May 5, 2015
    Assignee: Lonza AG
    Inventors: Dominique Roberge, Norbert Kockmann, Michael Gottsponer, Markus Eyholzer
  • Publication number: 20140322105
    Abstract: A micro-reactor system assembly comprises a stack of at least n process modules (1-6), wherein n is an integer equal to or greater than 1, made from a rigid first material and comprising at least one reactive fluid passage (1A, 1B, 2A, 3A, 6A) for accommodating and guiding a reactive fluid, and at least n+1 heat exchange modules (7, 8) made from a ductile second material other than said first material and comprising at least one heat exchange fluid passage (7A, 8A) for accommodating and guiding a heat exchange fluid, wherein each process module (1-6) is sandwiched between two adjacent heat exchange modules (7, 8).
    Type: Application
    Filed: July 14, 2014
    Publication date: October 30, 2014
    Applicant: Lonza AG
    Inventors: Dominique Roberge, Nikolaus Bieler, Bertin Zimmermann, Rainald Forbert
  • Patent number: 8632734
    Abstract: A microreaction device or system (4) includes at least one thermal control fluidic passage (C,E) and a principal working fluidic passage (A) with average cross-sectional area in the range of 0.25 to 100 mm2, and having a primary entrance (92) and multiple secondary entrances (94) with the spacing between secondary entrances (94) having a length along the passage (A) of at least two times the root of the average cross-sectional area of the passage (A). The device or system (4) also includes at least one secondary working fluidic passage (B) having an entrance (102) and multiple exits (106) including a final exit (106), each exit (106) being in fluid communication with a corresponding one of the multiple secondary entrances (94) of the principal fluidic passage (A).
    Type: Grant
    Filed: May 7, 2007
    Date of Patent: January 21, 2014
    Assignee: Corning Incorporated
    Inventors: Philippe J Barthe, Nikolaus Bieler, Celine Claude Guermeur, Olivier Lobet, Maxime Moreno, Dominique Roberge, Pierre Woehl
  • Publication number: 20130259768
    Abstract: A micro-reactor system assembly comprises a stack of at least n process modules (1-6), wherein n is an integer equal to or greater than 1, made from a rigid first material and comprising at least one reactive fluid passage (1A, 1B, 2A, 3A, 6A) for accommodating and guiding a reactive fluid, and at least n+1 heat exchange modules (7, 8) made from a ductile second material other than said first material and comprising at least one heat exchange fluid passage (7A, 8A) for accommodating and guiding a heat exchange fluid, wherein each process module (1-6) is sandwiched between two adjacent heat exchange modules (7, 8).
    Type: Application
    Filed: May 22, 2013
    Publication date: October 3, 2013
    Applicant: LONZA AG
    Inventors: Dominique Roberge, Nikolaus Bieler, Bertin Zimmermann, Rainald Forbert
  • Patent number: 8512653
    Abstract: A micro-reactor system assembly comprises a stack of at least n process modules (1-6), wherein n is an integer equal to or greater than 1, made from a rigid first material and comprising at least one reactive fluid passage (1A, 1B, 2A, 3A, 6A) for accommodating and guiding a reactive fluid, and at least n+1 heat exchange modules (7, 8) made from a ductile second material other than said first material and comprising at least one heat exchange fluid passage (7A, 8A) for accommodating and guiding a heat exchange fluid, wherein each process module (1-6) is sandwiched between two adjacent heat exchange modules (7, 8).
    Type: Grant
    Filed: March 29, 2012
    Date of Patent: August 20, 2013
    Assignee: Lonza AG
    Inventors: Dominique Roberge, Nikolaus Bieler, Bertin Zimmermann, Rainald Forbert
  • Patent number: 8287824
    Abstract: A micro-reactor system assembly comprises a stack of at least n process modules (1-6), wherein n is an integer equal to or greater than 1, made from a rigid first material and comprising at least one reactive fluid passage (1A, 1B, 2A, 3A, 6A) for accommodating and guiding a reactive fluid, and at least n+1 heat exchange modules (7, 8) made from a ductile second material other than said first material and comprising at least one heat exchange fluid passage (7A, 8A) for accommodating and guiding a heat exchange fluid, wherein each process module (1-6) is sandwiched between two adjacent heat exchange modules (7, 8).
    Type: Grant
    Filed: March 1, 2011
    Date of Patent: October 16, 2012
    Assignee: Lonza AG
    Inventors: Dominique Roberge, Nikolaus Bieler, Bertin Zimmermann, Rainald Forbert
  • Patent number: 8230877
    Abstract: A dosage system for feeding a fluid (A) to a static mixer (1), said system comprising a tank (2) containing said fluid (A) at a predetermined pressure, a fluid passage (3) connecting said container (1) and tank (2), a control valve (4) provided within said fluid passage (3) to control the flow of said fluid (A) from said tank into said container; and a controller (6) for receiving a target flow rate (SP_Q) of said fluid (A), and an actual flow rate (PV_Q) of said fluid (A), and for outputting a control signal (MV_L) to said control valve (4) indicating a valve position to adjust the flow rate. Further provided is a method for controlling said dosage system.
    Type: Grant
    Filed: October 23, 2006
    Date of Patent: July 31, 2012
    Assignee: Lonza AG
    Inventors: Dominique Roberge, Michael Amrhein, Yves Glatz
  • Publication number: 20120189511
    Abstract: A micro-reactor system assembly comprises a stack of at least n process modules (1-6), wherein n is an integer equal to or greater than 1, made from a rigid first material and comprising at least one reactive fluid passage (1A, 1B, 2A, 3A, 6A) for accommodating and guiding a reactive fluid, and at least n+1 heat exchange modules (7, 8) made from a ductile second material other than said first material and comprising at least one heat exchange fluid passage (7A, 8A) for accommodating and guiding a heat exchange fluid, wherein each process module (1-6) is sandwiched between two adjacent heat exchange modules (7, 8).
    Type: Application
    Filed: March 29, 2012
    Publication date: July 26, 2012
    Applicant: LONZA AG
    Inventors: Dominique Roberge, Nikolaus Bieler, Bertin Zimmermann, Rainald Forbert
  • Patent number: 8198487
    Abstract: The present invention relates to a process for lithium exchange reactions comprising mixing at least two fluids in a microreactor having at least two injection points.
    Type: Grant
    Filed: February 1, 2008
    Date of Patent: June 12, 2012
    Assignee: Lonza AG
    Inventors: Dominique Roberge, Wilhelm Quittmann, Markus Eyholzer, Bertin Zimmermann, Fabio Rainone
  • Publication number: 20120045376
    Abstract: A method of manufacturing a target reactor having a flow-channel system in which a plurality of reactants continuously flowing into said target reactor are mixed and interconvert to form a target volumetric flow-rate (f2) of a product continuously flowing out of said target reactor, wherein the smallest hydraulic diameter (dh2) of said target reactor is calculated based on the relationship d h ? ? 2 = d h ? ? 1 ? ( f 2 f 1 ) 3 - n 7 - n in a turbulent or transitional turbulent flow, wherein n is a non-integer number with 1>n?0, between the corresponding smallest hydraulic diameter (dh1) of a standard reactor having the same fluidic type of flow-channel system, f1 is a standard volumetric flow-rate of said standard reactor carrying out the same interconversion, and f2 is said target volumetric flow-rate.
    Type: Application
    Filed: May 12, 2010
    Publication date: February 23, 2012
    Inventors: Dominique Roberge, Norbert Kockmann, Michael Gottsponer, Markus Eyholzer