Patents by Inventor Dominique Swinnen

Dominique Swinnen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMT Inhibiting Methods and Compositions
    Publication number: 20210139479
    Abstract: This invention relates to compounds, pharmaceutical compositions and their use for treating neuropsychiatric and neurodegenerative disorders. In particular, the invention relates to inhibitors of catechol-O-methyltransferase and their use as therapeutics for central nervous system disease.
    Type: Application
    Filed: January 22, 2021
    Publication date: May 13, 2021
    Inventors: James Barrow, Glen Ernst, Dominique Swinnen, Florian Montel, Sabine Defays, Yifeng Huang, Pablo de Leon, Michael Steven Poslusney
  • COMT inhibiting methods and compositions
    Patent number: 10934283
    Abstract: Compounds that inhibit COMT enzyme and pharmaceutical compositions comprising the same are provided herein. Methods of treating various psychiatric and neurological disorders with the compounds and pharmaceutical compositions described herein are also provided.
    Type: Grant
    Filed: November 25, 2016
    Date of Patent: March 2, 2021
    Assignee: LIEBER INSTITUTE, INC.
    Inventors: James Barrow, Glen Ernst, Dominique Swinnen, Florian Montel, Sabine Defays, Yifang Huang, Pablo de León, Michael Steven Poslusney
  • Imidazo-oxadiazole and imidazo-thiadiazole derivatives
    Patent number: 10696690
    Abstract: The present invention provides compounds of Formula (I) used as Amyloid beta lowering agent for the treatment of neurodegenerative diseases.
    Type: Grant
    Filed: December 1, 2017
    Date of Patent: June 30, 2020
    Assignee: Ares Trading S.A.
    Inventors: Anna Quattropani, Dominique Swinnen
  • COMT Inhibiting Methods and Compositions
    Publication number: 20180305354
    Abstract: Compounds that inhibit COMT enzyme and pharmaceutical compositions comprising the same are provided herein. Methods of treating various psychiatric and neurological disorders with the compounds and pharmaceutical compositions described herein are also provided.
    Type: Application
    Filed: November 25, 2016
    Publication date: October 25, 2018
    Inventors: James Barrow, Glen Ernst, Dominique Swinnen, Florian Montel, Sabine Defays, Yifang Huang, Pablo de LEÓN, Michael Steven Poslusney
  • IMIDAZO-OXADIAZOLE AND IMIDAZO-THIADIAZOLE DERIVATIVES
    Publication number: 20180215770
    Abstract: The present invention provides compounds of Formula (I) used as Amyloid beta lowering agent for the treatment of neurodegenerative diseases.
    Type: Application
    Filed: December 1, 2017
    Publication date: August 2, 2018
    Inventors: Anna Quattropani, Dominique Swinnen
  • Imidazo-oxadiazole and imidazo-thiadiazole derivatives
    Patent number: 9932354
    Abstract: The present invention provides compounds of Formula (I) used as Amyloid beta lowering agent for the treatment of neurodegenerative diseases.
    Type: Grant
    Filed: May 23, 2013
    Date of Patent: April 3, 2018
    Assignee: Ares Trading S.A.
    Inventors: Anna Quattropani, Dominique Swinnen
  • Alpha-amino boronic acid derivatives, selective immunoproteasome inhibitors
    Patent number: 9688702
    Abstract: The present invention provides compounds of Formula (I) as inhibitors of LMP7 for the treatment of autoimmune and inflammatory diseases.
    Type: Grant
    Filed: December 21, 2012
    Date of Patent: June 27, 2017
    Assignee: Ares Trading
    Inventors: Dominique Swinnen, Stefano Crosignani, Jeyaprakashnarayanan Seenisamy, Federica Morandi
  • Alpha hydroxy amides
    Patent number: 9585891
    Abstract: The present invention relates to alpha hydroxy amides including compounds of formula I: and related compounds and their use in the prophylaxis and treatment of inflammatory disorders and diseases, wherein T1, T2, W and RW have the meanings given in claim 1.
    Type: Grant
    Filed: September 10, 2013
    Date of Patent: March 7, 2017
    Assignee: MERCK PATENT GMBH
    Inventors: Mathilde Muzerelle, Dominique Swinnen, Jeyaprakashnarayanan Seenisamy
  • Tetraaza-cyclopenta[a]indenyl and their use as positive allosteric modulators
    Patent number: 9403835
    Abstract: The present invention provides compounds of Formula (I) as M1 receptor positive allosteric modulators for the treatment of diseases mediated by the muscarinic M1 mediator.
    Type: Grant
    Filed: November 30, 2012
    Date of Patent: August 2, 2016
    Assignee: Ares Trading S.A.
    Inventors: Dominique Swinnen, Cyril Montagne, Vincent Pomel, Anna Quattropani, Jerome Molette, Patrick Gerber
  • Spiro tetrahydro—benzothiophen derivatives useful for the treatment neurodegenerative diseases
    Patent number: 9233982
    Abstract: The present invention provide compounds of Formula (I) used as BACE inhibitors for the treatment of neurodegenerative diseases.
    Type: Grant
    Filed: May 10, 2013
    Date of Patent: January 12, 2016
    Assignee: Ares Trading S.A.
    Inventors: Anna Quattropani, Dominique Swinnen
  • ALPHA HYDROXY AMIDES
    Publication number: 20150250792
    Abstract: The present invention relates to alpha hydroxy amides including compounds of formula I and related compounds and their use in the prophylaxis and treatment of inflammatory disorders and diseases, wherein: T1 denotes one of the following groups: T2-W denotes one of the following groups: W denotes a single bond, or a group selected from —CHRc— and —CH?CH—; and RW denotes a group selected from H, Hal, linear or branched alkyl, Ar, Het, Cyc, —(CH2)nAr, —(CH2)nHet, —(CH2)nCyc, —(CH2)nOAr, —(CH2)nOHet, —(CH2)nOCyc, or A.
    Type: Application
    Filed: September 10, 2013
    Publication date: September 10, 2015
    Inventors: Mathilde Muzerelle, Dominique Swinnen, Jeyaprakashnarayanan Seenisamy
  • IMIDAZO-OXADIAZOLE AND IMIDAZO-THIADIAZOLE DERIVATIVES
    Publication number: 20150175628
    Abstract: The present invention provides compounds of Formula (I) used as Amyloid beta lowering agent for the treatment of neurodegenerative diseases.
    Type: Application
    Filed: May 23, 2013
    Publication date: June 25, 2015
    Applicant: Merck Patent GmbH
    Inventors: Anna Quattropani, Dominique Swinnen
  • Triazolopyrazine derivatives
    Patent number: 9023851
    Abstract: Compounds of the formula I in which R1 and R2 have the meanings indicated in claim 1, are inhibitors of Syk, and can be employed, inter alia, for the treatment of rheumatoid arthritis.
    Type: Grant
    Filed: July 29, 2011
    Date of Patent: May 5, 2015
    Assignee: Merck Patent GmbH
    Inventors: Lars Burgdorf, Melanie Schultz, Carl Deutsch, Horacio Comas, Dominique Swinnen, Vincent Pomel, Pascale Gaillard, Brian Hodous
  • SPIRO TETRAHYDRO - BENZOTHIOPHEN DERIVATIVES USEFUL FOR THE TREATMENT NEURODEGENERATIVE DISEASES
    Publication number: 20150111882
    Abstract: The present invention provide compounds of Formula (I) used as BACE inhibitors for the treatment of neurodegenerative diseases.
    Type: Application
    Filed: May 10, 2013
    Publication date: April 23, 2015
    Applicant: Ares Trading S.A.
    Inventors: Anna Quattropani, Dominique Swinnen
  • TRIAZOLOPYRAZINE DERIVATIVES
    Publication number: 20150051202
    Abstract: Compounds of the formula I in which R1, R2 and R4 have the meanings indicated in Claim 1, are inhibitors of GCN2, and can be employed, inter alia, for the treatment of cancer.
    Type: Application
    Filed: February 14, 2013
    Publication date: February 19, 2015
    Applicant: Merck Patent GmbH
    Inventors: Kai Schiemann, Carl Deutsch, Guenter Hoelzemann, Daniel Kuhn, Ansgar Wegener, Dominique Swinnen, Horacio Comas
  • Tetraaza-cyclopenta[a]indenyl and their use as Positive Allosteric Modulators
    Publication number: 20150018343
    Abstract: The present invention provides compounds of Formula (I) as M1 receptor positive allosteric modulators for the treatment of diseases mediated by the muscarinic M1 mediator.
    Type: Application
    Filed: November 30, 2012
    Publication date: January 15, 2015
    Inventors: Dominique Swinnen, Cyril Montagne, Vincent Pomel, Anna Quattropani, Jerome Molette, Patrick Gerber
  • Alpha-amino boronic acid derivatives, selective immunoproteasome inhibitors
    Publication number: 20140364396
    Abstract: The present invention provides compounds of Formula (I) as inhibitors of LMP7 for the treatment of autoimmune and inflammatory diseases.
    Type: Application
    Filed: December 21, 2012
    Publication date: December 11, 2014
    Inventors: Dominique Swinnen, Stefano Crosignani, Jeyaprakashnarayanan Seenisamy, Federica Morandi
  • TRIAZOLOPYRAZINE DERIVATIVES
    Publication number: 20130225568
    Abstract: Compounds of the formula I in which R1 and R2 have the meanings indicated in claim 1, are inhibitors of Syk, and can be employed, inter alia, for the treatment of rheumatoid arthritis.
    Type: Application
    Filed: July 29, 2011
    Publication date: August 29, 2013
    Applicant: MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG
    Inventors: Lars Burgdorf, Melanie Schultz, Carl Deutsch, Horacio Comas, Dominique Swinnen, Vincent Pomel, Pascale Gaillard, Brian Hodous
  • Method for preparing substituted N-(3-amino-quinoxalin-2-yl)-sulfonamides and their intermediates N-(3-chloro-quinoxalin-2-yl)-sulfonamides
    Publication number: 20130211076
    Abstract: The present invention provides a new synthesis for preparing N-(3-amino-quinoxalin-2-yl)-sulfonamides of general formulae (I) or (I?) and intermediates sulfonamides of formula (II) or (II?):
    Type: Application
    Filed: October 18, 2011
    Publication date: August 15, 2013
    Applicant: MERCK SERONO S.A. GENEVA
    Inventors: Danig Pohin, Dominique Swinnen
  • Imidazothiadiazole derivatives
    Patent number: 8389554
    Abstract: Novel imidazo[2,1-b][1,3,4]thiadiazole derivatives of formula (I) wherein R1 and R2 have the meaning according to claim 1, are inhibitors of TGF-beta receptor I kinase, and can be employed, inter alia, for the treatment of tumors.
    Type: Grant
    Filed: July 1, 2009
    Date of Patent: March 5, 2013
    Assignee: Merck Patent Gesellschaft mit Beschränkter Haftung
    Inventors: Guenter Hoelzemann, Hartmut Greiner, Emilie Rossignol, Dominique Swinnen