Patents by Inventor Don A. Masquelier

Don A. Masquelier has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • AUTOMATED CELL PROCESSING METHODS, MODULES, INSTRUMENTS, AND SYSTEMS
    Publication number: 20200270601
    Abstract: In an illustrative embodiment, automated multi-module cell editing instruments are provided to automate multiple edits into nucleic acid sequences inside one or more cells.
    Type: Application
    Filed: April 1, 2020
    Publication date: August 27, 2020
    Inventors: Phillip Belgrader, Don Masquelier, Jorge Bernate, Ryan Gill, Kevin Ness
  • Instruments, modules, and methods for improved detection of edited sequences in live cells
    Patent number: 10752874
    Abstract: The present disclosure provides instruments, modules and methods for improved detection of edited cells following nucleic acid-guided nuclease genome editing. The disclosure provides improved automated instruments that perform methods—including high throughput methods—for screening cells that have been subjected to editing and identifying cells that have been properly edited.
    Type: Grant
    Filed: November 15, 2019
    Date of Patent: August 25, 2020
    Assignee: Inscripta, Inc.
    Inventors: Charles Johnson, Miles Gander, Don Masquelier, Phillip Belgrader, Andrew Garst, Matthew Estes, Bruce Chabansky, Jorge Bernate
  • Instruments, modules, and methods for improved detection of edited sequences in live cells
    Patent number: 10744463
    Abstract: The present disclosure provides instruments, modules and methods for improved detection of edited cells following nucleic acid-guided nuclease genome editing. The disclosure provides improved automated instruments that perform methods—including high throughput methods—for screening cells that have been subjected to editing and identifying cells that have been properly edited.
    Type: Grant
    Filed: April 9, 2020
    Date of Patent: August 18, 2020
    Assignee: Inscripta, Inc.
    Inventors: Phillip Belgrader, Don Masquelier, Matthew Estes, Bruce Chabansky, Andrew Garst, Richard Fox, Jorge Bernate
  • Electroporation cuvettes for automation
    Patent number: 10738327
    Abstract: The present invention relates to an electroporation device that may include many electroporation units and electroporation systems that can be used in an automated environment, e.g., as one station or module in a multi-station or multi-module cell processing environment. The electroporation device comprises an electroporation cuvette coupled with an adapter or engagement member at the top that is configured for engagement with liquid handling instrumentation, and a “sipper” conduit at the bottom for sample intake and output.
    Type: Grant
    Filed: August 22, 2018
    Date of Patent: August 11, 2020
    Assignee: Inscripta, Inc.
    Inventors: Jorge Bernate, Phil Belgrader, Don Masquelier, Vlorent Morina
  • Automated cell processing methods, modules, instruments, and systems
    Patent number: 10738301
    Abstract: In an illustrative embodiment, automated multi-module cell editing instruments are provided to automate multiple edits into nucleic acid sequences inside one or more cells.
    Type: Grant
    Filed: April 1, 2020
    Date of Patent: August 11, 2020
    Assignee: Inscripta, Inc.
    Inventors: Phillip Belgrader, Don Masquelier, Jorge Bernate, Ryan Gill, Kevin Ness
  • Automated cell processing instruments comprising reagent cartridges
    Patent number: 10737271
    Abstract: The present disclosure provides a reagent cartridge configured for use in an automated multi-module cell processing environment.
    Type: Grant
    Filed: March 23, 2020
    Date of Patent: August 11, 2020
    Assignee: Inscripta, Inc.
    Inventors: Brian Van Hatten, Don Masquelier, Phillip Belgrader, Jorge Bernate, Bruce Chabansky
  • INSTRUMENTS, MODULES, AND METHODS FOR IMPROVED DETECTION OF EDITED SEQUENCES IN LIVE CELLS
    Publication number: 20200248131
    Abstract: The present disclosure provides instruments, modules and methods for improved detection of edited cells following nucleic acid-guided nuclease genome editing. The disclosure provides improved automated instruments that perform methods—including high throughput methods—for screening cells that have been subjected to editing and identifying cells that have been properly edited.
    Type: Application
    Filed: March 16, 2020
    Publication date: August 6, 2020
    Inventors: Andrew Garst, Richard Fox, Phillip Belgrader, Don Masquelier
  • Instruments, modules, and methods for improved detection of edited sequences in live cells
    Patent number: 10723995
    Abstract: The present disclosure provides instruments, modules and methods for improved detection of edited cells following nucleic acid-guided nuclease genome editing. The disclosure provides improved automated instruments that perform methods—including high throughput methods—for screening cells that have been subjected to editing and identifying cells that have been properly edited.
    Type: Grant
    Filed: March 16, 2020
    Date of Patent: July 28, 2020
    Assignee: Inscripta, Inc.
    Inventors: Phillip Belgrader, Don Masquelier, Andrew Garst, Richard Fox
  • INSTRUMENTS, MODULES, AND METHODS FOR IMPROVED DETECTION OF EDITED SEQUENCES IN LIVE CELLS
    Publication number: 20200230556
    Abstract: The present disclosure provides instruments, modules and methods for improved detection of edited cells following nucleic acid-guided nuclease genome editing. The disclosure provides improved automated instruments that perform methods—including high throughput methods—for screening cells that have been subjected to editing and identifying cells that have been properly edited.
    Type: Application
    Filed: April 9, 2020
    Publication date: July 23, 2020
    Inventors: Phillip Belgrader, Don Masquelier, Matthew Estes, Bruce Chabansky, Andrew Garst, Richard Fox, Jorge Bernate
  • Methods for controlling the growth of prokaryotic and eukaryotic cells
    Patent number: 10717959
    Abstract: The present disclosure relates to methods for control of cell growth rates where cell growth is measured in situ. The methods are applicable to bacterial cells, mammalian cells, non-mammalian eukaryotic cells, plant cells, yeast cells, fungi, and archea.
    Type: Grant
    Filed: February 3, 2020
    Date of Patent: July 21, 2020
    Assignee: Inscripta, Inc.
    Inventors: Phillip Belgrader, Don Masquelier
  • METHODS FOR CONTROLLING THE GROWTH OF PROKARYOTIC AND EUKARYOTIC CELLS
    Publication number: 20200224146
    Abstract: The present disclosure relates to methods for control of cell growth rates where cell growth is measured in situ. The methods are applicable to bacterial cells, mammalian cells, non-mammalian eukaryotic cells, plant cells, yeast cells, fungi, and archea.
    Type: Application
    Filed: March 31, 2020
    Publication date: July 16, 2020
    Inventors: Phillip Belgrader, Don Masquelier
  • INSTRUMENTS, MODULES, AND METHODS FOR IMPROVED DETECTION OF EDITED SEQUENCES IN LIVE CELLS
    Publication number: 20200216794
    Abstract: The present disclosure provides instruments, modules and methods for improved detection of edited cells following nucleic acid-guided nuclease genome editing. The disclosure provides improved automated instruments that perform methods—including high throughput methods—for screening cells that have been subjected to editing and identifying cells that have been properly edited.
    Type: Application
    Filed: March 16, 2020
    Publication date: July 9, 2020
    Inventors: Phillip Belgrader, Don Masquelier, Andrew Garst, Richard Fox
  • INSTRUMENTS, MODULES, AND METHODS FOR IMPROVED DETECTION OF EDITED SEQUENCES IN LIVE CELLS
    Publication number: 20200216795
    Abstract: The present disclosure provides instruments, modules and methods for improved detection of edited cells following nucleic acid-guided nuclease genome editing. The disclosure provides improved automated instruments that perform methods—including high throughput methods—for screening cells that have been subjected to editing and identifying cells that have been properly edited.
    Type: Application
    Filed: March 18, 2020
    Publication date: July 9, 2020
    Inventors: Andrew Garst, Richard Fox, Phillip Belgrader, Don Masquelier
  • Automated cell processing methods, modules, instruments, and systems
    Patent number: 10689645
    Abstract: In an illustrative embodiment, automated multi-module cell editing instruments are provided to automate multiple edits into nucleic acid sequences inside one or more cells.
    Type: Grant
    Filed: March 18, 2020
    Date of Patent: June 23, 2020
    Assignee: Inscripta, Inc.
    Inventors: Phillip Belgrader, Don Masquelier, Jorge Bernate, Ryan Gill, Kevin Ness
  • AUTOMATED CELL GROWTH AND/OR CONCENTRATION MODULES AS STAND-ALONE DEVICES OR FOR USE IN MULTI-MODULE CELL PROCESSING INSTRUMENTATION
    Publication number: 20200190461
    Abstract: The present disclosure provides a cell growth, buffer exchange, and/or cell concentration/filtration device that may be used as a stand-alone device or as a module configured to be used in an automated multi-module cell processing environment.
    Type: Application
    Filed: February 22, 2020
    Publication date: June 18, 2020
    Inventors: Jorge Bernate, Don Masquelier, Phillip Belgrader, Bruce Chabansky
  • METHODS FOR CONTROLLING THE GROWTH OF PROKARYOTIC AND EUKARYOTIC CELLS
    Publication number: 20200172846
    Abstract: The present disclosure relates to methods for control of cell growth rates where cell growth is measured in situ. The methods are applicable to bacterial cells, mammalian cells, non-mammalian eukaryotic cells, plant cells, yeast cells, fungi, and archea.
    Type: Application
    Filed: February 3, 2020
    Publication date: June 4, 2020
    Inventors: Phillip Belgrader, Don Masquelier
  • AUTOMATED CELL PROCESSING METHODS, MODULES, INSTRUMENTS, AND SYSTEMS
    Publication number: 20200157532
    Abstract: In an illustrative embodiment, automated multi-module cell editing instruments are provided to automate multiple edits into nucleic acid sequences inside one or more cells.
    Type: Application
    Filed: January 23, 2020
    Publication date: May 21, 2020
    Inventors: Don Masquelier, Phillip Belgrader, Jorge Bernate, Ryan Gill, Kevin Ness
  • Instruments, modules, and methods for improved detection of edited sequences in live cells
    Patent number: 10647958
    Abstract: The present disclosure provides instruments, modules and methods for improved detection of edited cells following nucleic acid-guided nuclease genome editing. The disclosure provides improved automated instruments that perform methods—including high throughput methods—for screening cells that have been subjected to editing and identifying cells that have been properly edited.
    Type: Grant
    Filed: November 25, 2019
    Date of Patent: May 12, 2020
    Assignee: Inscripta, Inc.
    Inventors: Phillip Belgrader, Don Masquelier, Bruce Chabansky, Jorge Bernate, Andrew Garst, Richard Fox
  • Automated cell processing methods, modules, instruments, and systems
    Patent number: 10647982
    Abstract: In an illustrative embodiment, automated multi-module cell editing instruments are provided to automate multiple edits into nucleic acid sequences inside one or more cells.
    Type: Grant
    Filed: January 23, 2020
    Date of Patent: May 12, 2020
    Assignee: Inscripta, Inc.
    Inventors: Don Masquelier, Phillip Belgrader, Jorge Bernate, Ryan Gill, Kevin Ness
  • Automated cell processing instruments comprising reagent cartridges
    Patent number: 10639637
    Abstract: The present disclosure provides a reagent cartridge configured for use in an automated multi-module cell processing environment.
    Type: Grant
    Filed: January 22, 2020
    Date of Patent: May 5, 2020
    Assignee: Inscripta, Inc.
    Inventors: Brian Van Hatten, Don Masquelier, Phillip Belgrader, Jorge Bernate, Bruce Chabansky