Patents by Inventor Don-Ching Lee

Don-Ching Lee has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS TO ENHANCE NERVE REGENERATION UTILIZING NEURAL STEM CELLS AND IL12P40
    Publication number: 20190351022
    Abstract: The present application provides a composition and methods to enhance nerve regeneration utilizing at least one component of neural stem cells or IL12p40. The composition comprises neural stem cells and a neurotrophic factor, which is constructed by IL12p40 as at least one subunit. The methods to enhance nerve regeneration comprise providing a nerve regeneration composition comprising a neurotrophic factor containing IL12p40 as at least one subunit to a subject. The composition of the methods can further comprise neural stem cells.
    Type: Application
    Filed: July 17, 2019
    Publication date: November 21, 2019
    Applicant: National Health Research Institutes
    Inventors: Ing-Ming CHIU, Ya-Hui CHI, Don-Ching LEE
  • Methods to enhance nerve regeneration utilizing neural stem cells and IL12P40
    Patent number: 10391149
    Abstract: The present application provides a composition and methods to enhance nerve regeneration utilizing at least one component of neural stem cells or IL12p40. The composition comprises neural stem cells and a neurotrophic factor, which is constructed by IL12p40 as at least one subunit. The methods to enhance nerve regeneration comprise providing a nerve regeneration composition comprising a neurotrophic factor containing IL12p40 as at least one subunit to a subject. The composition of the methods can further comprise neural stem cells.
    Type: Grant
    Filed: August 14, 2015
    Date of Patent: August 27, 2019
    Assignee: NATIONAL HEALTH RESEARCH INSTITUTES
    Inventors: Ing-Ming Chiu, Ya-Hui Chi, Don-Ching Lee
  • METHODS TO ENHANCE NERVE REGENERATION UTILIZING NEURAL STEM CELLS AND IL12P40
    Publication number: 20170224776
    Abstract: The present application provides a composition and methods to enhance nerve regeneration utilizing at least one component of neural stem cells or IL12p40. The composition comprises neural stem cells and a neurotrophic factor, which is constructed by IL12p40 as at least one subunit. The methods to enhance nerve regeneration comprise providing a nerve regeneration composition comprising a neurotrophic factor containing IL12p40 as at least one subunit to a subject. The composition of the methods can further comprise neural stem cells.
    Type: Application
    Filed: August 14, 2015
    Publication date: August 10, 2017
    Applicant: National Health Research Institutes
    Inventors: Ing-Ming CHIU, Ya-Hui CHI, Don-Ching LEE
  • Ultra-nanocrystalline diamond as a biomaterial for enhancing proliferation and differentiation of neural stem cells
    Patent number: 8101409
    Abstract: Compositions for promoting growth and/or differentiation of a stem cell are disclosed. The composition comprises: a) a diamond film; b) a stem cell cultured on the diamond film; and c) a medium bathing the stem cell. The stem cell may be a mammalian neural stem cell and the diamond film may comprise a hydrogen-terminated or an oxygen-terminated surface. The hydrogen-terminated surface promotes proliferation and differentiation of a neural stem cell into neurons, and the oxygen-terminated surface promotes a neural stem cell to proliferate and differentiate into oligodendrocytes.
    Type: Grant
    Filed: October 5, 2009
    Date of Patent: January 24, 2012
    Assignees: National Health Research Institutes, National Tsing Hua University
    Inventors: Ing-Ming Chiu, Ying-Chieh Chen, Don-Ching Lee, Nyan-Hwa Tai
  • ULTRA-NANOCRYSTALLINE DIAMOND AS A BIOMATERIAL FOR ENHANCING PROLIFERATION AND DIFFERENTIATION OF NEURAL STEM CELLS
    Publication number: 20110081395
    Abstract: Compositions for promoting growth and/or differentiation of a stem cell are disclosed. The composition comprises: a) a diamond film; b) a stem cell cultured on the diamond film; and c) a medium bathing the stem cell. The stem cell may be a mammalian neural stem cell and the diamond film may comprise a hydrogen-terminated or an oxygen-terminated surface. The hydrogen-terminated surface promotes proliferation and differentiation of a neural stem cell into neurons, and the oxygen-terminated surface promotes a neural stem cell to proliferate and differentiate into oligodendrocytes.
    Type: Application
    Filed: October 5, 2009
    Publication date: April 7, 2011
    Applicants: NATIONAL HEALTH RESEARCH INSTITUTES, NATIONAL TSING HUA UNIVERSITY
    Inventors: ING-MING CHIU, YING-CHIEH CHEN, DON-CHING LEE, NYAN-HWA TAI