Patents by Inventor Don Gabriel

Don Gabriel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8163151
    Abstract: Methods of analyzing the electrophoretic mobility distribution of von Willebrand factor (vWF) multimers include providing a sample medium comprising a plurality vWF multimers. The vWF multimers are electrophoretically separated by electrohoretic mobility in the sample medium by subjecting said sample medium to an electric field to provide separated vWF multimers. The separated vWF multimers in the sample medium are exposed to a light source to produce scattered light. The scattered light is detected, and the electrophoretic mobility distribution of the separated vWF multimers is determined from the detected scattered light.
    Type: Grant
    Filed: July 21, 2010
    Date of Patent: April 24, 2012
    Assignee: The University of North Carolina at Chapel Hill
    Inventor: Don A. Gabriel
  • Publication number: 20100284996
    Abstract: Methods of analyzing the electrophoretic mobility distribution of von Willebrand factor (vWF) multimers include providing a sample medium comprising a plurality vWF multimers. The vWF multimers are electrophoretically separated by electrohoretic mobility in the sample medium by subjecting said sample medium to an electric field to provide separated vWF multimers. The separated vWF multimers in the sample medium are exposed to a light source to produce scattered light. The scattered light is detected, and the electrophoretic mobility distribution of the separated vWF multimers is determined from the detected scattered light.
    Type: Application
    Filed: July 21, 2010
    Publication date: November 11, 2010
    Inventor: Don A. Gabriel
  • Patent number: 7780831
    Abstract: Methods of analyzing the electrophoretic mobility distribution of von Willebrand factor (vWF) multimers include providing a sample medium comprising a plurality vWF multimers. The vWF multimers are electrophoretically separated by electrohoretic mobility in the sample medium by subjecting said sample medium to an electric field to provide separated vWF multimers. The separated vWF multimers in the sample medium are exposed to a light source to produce scattered light. The scattered light is detected, and the electrophoretic mobility distribution of the separated vWF multimers is determined from the detected scattered light.
    Type: Grant
    Filed: July 7, 2004
    Date of Patent: August 24, 2010
    Assignee: The University of North Carolina at Chapel Hill
    Inventor: Don A. Gabriel
  • Publication number: 20100203499
    Abstract: Methods for identifying a biological particle in a sample medium include generating an Electrophoretic Quasi-elastic Light Scattering (EQELS) spectrum for the biological particle in the sample medium. The EQELS spectrum is compared to a reference database comprising a plurality of spectra, and each of the plurality of spectra correspond to an EQELS spectrum for one of a plurality of known biological particles. The biological particle in the sample medium is identified from the comparison.
    Type: Application
    Filed: July 30, 2009
    Publication date: August 12, 2010
    Inventor: Don A. Gabriel
  • Patent number: 7771660
    Abstract: Methods for identifying a biological particle in a sample medium include generating an Electrophoretic Quasi-elastic Light Scattering (EQELS) spectrum for the biological particle in the sample medium. The EQELS spectrum is compared to a reference database comprising a plurality of spectra, and each of the plurality of spectra correspond to an EQELS spectrum for one of a plurality of known biological particles. The biological particle in the sample medium is identified from the comparison.
    Type: Grant
    Filed: May 3, 2005
    Date of Patent: August 10, 2010
    Assignee: University of North Carolina at Chapel Hill
    Inventor: Don A. Gabriel
  • Publication number: 20100190148
    Abstract: Methods for identifying a biological particle in a sample medium include generating an Electrophoretic Quasi-elastic Light Scattering (EQELS) spectrum for the biological particle in the sample medium. The EQELS spectrum is compared to a reference database comprising a plurality of spectra, and each of the plurality of spectra correspond to an EQELS spectrum for one of a plurality of known biological particles. The biological particle in the sample medium is identified from the comparison.
    Type: Application
    Filed: July 30, 2009
    Publication date: July 29, 2010
    Inventor: Don A. Gabriel
  • Publication number: 20100035235
    Abstract: Methods for using focused light scattering techniques for the optical sensing of biological particles suspended in a liquid medium are disclosed. The optical sensing enables one to characterize particles size and/or distribution in a given sample. This, in turn, allows one to identify the biological particles, determine their relative particle density, detect particle shedding, and identify particle aggregation. The methods are also useful in screening and optimizing drug candidates, evaluating the efficacy and dosage levels of such drugs, and in personalized medicine applications.
    Type: Application
    Filed: July 14, 2009
    Publication date: February 11, 2010
    Applicant: INVITROX, INC.
    Inventor: Don Gabriel
  • Publication number: 20090291430
    Abstract: Methods for identifying a biological particle in a sample medium include generating an Electrophoretic Quasi-elastic Light Scattering (EQELS) spectrum for the biological particle in the sample medium. The EQELS spectrum is compared to a reference database comprising a plurality of spectra, and each of the plurality of spectra correspond to an EQELS spectrum for one of a plurality of known biological particles. The biological particle in the sample medium is identified from the comparison.
    Type: Application
    Filed: July 30, 2009
    Publication date: November 26, 2009
    Inventor: Don A. Gabriel
  • Publication number: 20050250095
    Abstract: Methods for identifying a biological particle in a sample medium include generating an Electrophoretic Quasi-elastic Light Scattering (EQELS) spectrum for the biological particle in the sample medium. The EQELS spectrum is compared to a reference database comprising a plurality of spectra, and each of the plurality of spectra correspond to an EQELS spectrum for one of a plurality of known biological particles. The biological particle in the sample medium is identified from the comparison.
    Type: Application
    Filed: May 3, 2005
    Publication date: November 10, 2005
    Applicant: Myers Bigel Sibley & Sajovec, P.A.
    Inventor: Don Gabriel
  • Patent number: 6943269
    Abstract: The present invention provides basic ionic contrast agents that have anticoagulant activity. The contrast media incorporate a lysine or arginine group or derivative, and have a free amino or guanidino group. Methods of using the contrast media are also disclosed.
    Type: Grant
    Filed: June 20, 2003
    Date of Patent: September 13, 2005
    Assignee: University of North Carolina - Chapel Hill
    Inventors: Don A. Gabriel, Laura J. Melton
  • Publication number: 20050051428
    Abstract: Methods of analyzing the electrophoretic mobility distribution of von Willebrand factor (vWF) multimers include providing a sample medium comprising a plurality vWF multimers. The vWF multimers are electrophoretically separated by electrohoretic mobility in the sample medium by subjecting said sample medium to an electric field to provide separated vWF multimers. The separated vWF multimers in the sample medium are exposed to a light source to produce scattered light. The scattered light is detected, and the electrophoretic mobility distribution of the separated vWF multimers is determined from the detected scattered light.
    Type: Application
    Filed: July 7, 2004
    Publication date: March 10, 2005
    Inventor: Don Gabriel
  • Publication number: 20040081620
    Abstract: The present invention provides basic ionic contrast agents that have anticoagulant activity. The contrast media incorporate a lysine or arginine group or derivative, and have a free amino or guanidino group. Methods of using the contrast media are also disclosed.
    Type: Application
    Filed: June 20, 2003
    Publication date: April 29, 2004
    Inventors: Don A. Gabriel, Laura J. Melton
  • Patent number: 6610850
    Abstract: The present invention provides basic ionic contrast agents that have anticoagulant activity. The contrast media incorporate a lysine or arginine group or derivative, and have a free amino or guanidino group. Methods of using the contrast media are also disclosed.
    Type: Grant
    Filed: September 27, 2002
    Date of Patent: August 26, 2003
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: Don A. Gabriel, Laura J. Melton
  • Publication number: 20030120034
    Abstract: The present invention provides basic ionic contrast agents that have anticoagulant activity. The contrast media incorporate a lysine or arginine group or derivative, and have a free amino or guanidino group. Methods of using the contrast media are also disclosed.
    Type: Application
    Filed: September 27, 2002
    Publication date: June 26, 2003
    Inventors: Don A. Gabriel, Laura J. Melton
  • Patent number: 6498273
    Abstract: The present invention provides basic ionic contrast agents that have anticoagulant activity. The contrast media incorporate a lysine or arginine group or derivative, and have a free amino or guanidino group. Methods of using the contrast media are also disclosed.
    Type: Grant
    Filed: May 25, 2001
    Date of Patent: December 24, 2002
    Assignee: The University of North Carolina
    Inventors: Don A. Gabriel, Laura J. Melton
  • Publication number: 20020040162
    Abstract: The present invention provides basic ionic contrast agents that have anticoagulant activity. The contrast media incorporate a lysine or arginine group or derivative, and have a free amino or guanidino group. Methods of using the contrast media are also disclosed.
    Type: Application
    Filed: May 25, 2001
    Publication date: April 4, 2002
    Inventors: Don A. Gabriel, Laura J. Melton
  • Patent number: 6265610
    Abstract: The present invention provides basic ionic contrast agents that have anticoagulant activity. The contrast media incorporate a lysine or arginine group or derivative, and have a free amino or guanidino group. Methods of using the contrast media are also disclosed.
    Type: Grant
    Filed: January 11, 2000
    Date of Patent: July 24, 2001
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: Don A. Gabriel, Laura J. Melton