Abstract: A pulse center detection circuit, which utilizes the characteristics of the comparator combined with its positive input terminal and negative input terminal during the charging and discharging process. Thus, the comparator can output a detected pulse center signal accurately. The pulse center detection circuit of the invention utilizes an analog differential circuit in order to decrease noise interference and the pulse center can be precisely detected. Thus, the invention can be broadly used for a monitor circuit design to detect a flyback pulse center and can also be used for a general periodic pulse which requires detection of its pulse center.