Abstract: The present application discloses a machine for inserting ampoules or similar containers in holders suitable for packing and shipping. A conveyor chain carries a series of trays having receptacles adapted to receive a preselected number of ampoules. A hopper feeds the preselected number of ampoules into the receptacles by gravity. An inclined ramp accommodates a stack of flat holder blanks of cardboard or the like. Each tray is provided with projection means which grasp a single blank from the stack and moves it along in alignment with the tray. A guide system has rails extending longitudinally along the conveyor adapted to engage the blank and erect it to a U-shape. A ramp adjacent the chain has a contoured camming surface which engages the ampoules and moves the ampoules transversely into appropriate apertures in the aligned, erected holders.