Patents by Inventor Don McClure

Don McClure has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11182357
    Abstract: Systems and methods for the migration of large amounts of time-varying data from a source database to a target database are disclosed. After completion of an initial long-duration migration, a validation is performed to determine if any groups of data were updated in the source database during the initial migration. Updated data is then topped-off by migration to a temporary container before merging into the target database. Subsequent validation can confirm that migration is complete or initiate one or more additional top-off migrations.
    Type: Grant
    Filed: September 14, 2017
    Date of Patent: November 23, 2021
    Assignee: Walmart Apollo, LLC
    Inventors: Chris Daniels, Steve Hager, Michael Stuker, Joe Don McClure
  • Publication number: 20190258614
    Abstract: Systems and methods for the migration of large amounts of time-varying data from a source database to a target database are disclosed. After completion of an initial long-duration migration, a validation is performed to determine if any groups of data were updated in the source database during the initial migration. Updated data is then topped-off by migration to a temporary container before merging into the target database. Subsequent validation can confirm that migration is complete or initiate one or more additional top-off migrations.
    Type: Application
    Filed: September 14, 2017
    Publication date: August 22, 2019
    Inventors: Chris Daniels, Steve Hager, Michael Stuker, Joe Don McClure
  • Patent number: 9321996
    Abstract: The present invention provides a cell culture medium formulation that supports the in vitro cultivation, particularly in suspension, of mammalian cells, particularly epithelial cells and fibroblast cells, and methods for cultivating mammalian cells in suspension in vitro using these media. The media comprise a basal medium and a polyanionic or polyanionic compound, preferably a polysulfonated or polysulfated compound, and more preferably dextran sulfate. The present invention also provides chemically defined, protein-free eukaryotic cell culture media comprising an iron chelate and zinc, which is capable of supporting the growth (and particularly the high-density growth of mammalian cells) in suspension culture, increasing the level of expression of recombinant protein in cultured cells, and/or increasing virus production in cultured cells.
    Type: Grant
    Filed: September 10, 2012
    Date of Patent: April 26, 2016
    Assignee: Life Technologies Corporation
    Inventors: Stephen Gorfien, Richard Fike, Glenn Godwin, Joyce Dzimian, David Epstein, Dale Gruber, Don McClure, Paul Price
  • Publication number: 20150079659
    Abstract: The present invention provides a cell culture medium formulation that supports the in vitro cultivation, particularly in suspension, of mammalian cells, particularly epithelial cells and fibroblast cells, and methods for cultivating mammalian cells in suspension in vitro using these media. The media comprise a basal medium and a polyanionic or polyanionic compound, preferably a polysulfonated or polysulfated compound, and more preferably dextran sulfate. The present invention also provides chemically defined, protein-free eukaryotic cell culture media comprising an iron chelate and zinc, which is capable of supporting the growth (and particularly the high-density growth of mammalian cells) in suspension culture, increasing the level of expression of recombinant protein in cultured cells, and/or increasing virus production in cultured cells.
    Type: Application
    Filed: May 22, 2014
    Publication date: March 19, 2015
    Applicant: LIFE TECHNOLOGIES CORPORATION
    Inventors: Stephen GORFIEN, Richard FIKE, GLENN GODWIN, JOYCE WOLANSKE, David EPSTEIN, Dale GRUBER, Don MCCLURE, Paul PRICE
  • Patent number: 8815573
    Abstract: The present invention provides a cell culture medium formulation that supports the in vitro cultivation, particularly in suspension, of mammalian cells, particularly epithelial cells and fibroblast cells, and methods for cultivating mammalian cells in suspension in vitro using these media. The present invention also provides chemically defined, protein-free eukaryotic cell culture media comprising an iron chelate and zinc, which is capable of supporting the growth (and particularly the high-density growth of mammalian cells) in suspension culture, increasing the level of expression of recombinant protein in cultured cells, and/or increasing virus production in cultured cells. The invention also provides kits for use in the cultivation of a mammalian epithelial cell that comprise one or more containers, wherein a first container contains the culture medium of the invention. These kits may further comprise one or more additional containers containing one or more supplements.
    Type: Grant
    Filed: March 20, 2013
    Date of Patent: August 26, 2014
    Assignee: Life Technologies Corporation
    Inventors: Stephen F. Gorfien, Richard Fike, Glenn P. Godwin, Joyce L. Wolanske, David A. Epstein, Dale Gruber, Don McClure, Paul J. Price
  • Patent number: 8785194
    Abstract: The present invention provides a cell culture medium formulation that supports the in vitro cultivation, particularly in suspension, of mammalian cells, particularly epithelial cells and fibroblast cells, and methods for cultivating mammalian cells in suspension in vitro using these media. The media comprise a basal medium and a polyanionic or polyanionic compound, preferably a polysulfonated or polysulfated compound, and more preferably dextran sulfate. The present invention also provides chemically defined, protein-free eukaryotic cell culture media comprising an iron chelate and zinc, which is capable of supporting the growth (and particularly the high-density growth of mammalian cells) in suspension culture, increasing the level of expression of recombinant protein in cultured cells, and/or increasing virus production in cultured cells.
    Type: Grant
    Filed: May 8, 2009
    Date of Patent: July 22, 2014
    Assignee: Life Technologies Corporation
    Inventors: Stephen Gorfien, Richard Fike, Glenn Godwin, Joyce Dzimian, David A. Epstein, Dale Gruber, Don McClure, Paul Price
  • Publication number: 20130065275
    Abstract: The present invention provides a cell culture medium formulation that supports the in vitro cultivation, particularly in suspension, of mammalian cells, particularly epithelial cells and fibroblast cells, and methods for cultivating mammalian cells in suspension in vitro using these media. The media comprise a basal medium and a polyanionic or polyanionic compound, preferably a polysulfonated or polysulfated compound, and more preferably dextran sulfate. The present invention also provides chemically defined, protein-free eukaryotic cell culture media comprising an iron chelate and zinc, which is capable of supporting the growth (and particularly the high-density growth of mammalian cells) in suspension culture, increasing the level of expression of recombinant protein in cultured cells, and/or increasing virus production in cultured cells.
    Type: Application
    Filed: September 10, 2012
    Publication date: March 14, 2013
    Applicant: LIFE TECHNOLOGIES CORPORATION
    Inventors: Stephen F. GORFIEN, Richard M. Fike, Glenn P. Godwin, Joyce L. Dzimian, David A. Epstein, Dale Gruber, Don McClure, Paul J. Price
  • Patent number: 8198084
    Abstract: The present invention provides a cell culture medium formulation that supports the in vitro cultivation, particularly in suspension, of mammalian cells, particularly epithelial cells and fibroblast cells, and methods for cultivating mammalian cells in suspension in vitro using these media. The media comprise a basal medium and a polyanionic or polyanionic compound, preferably a polysulfonated or polysulfated compound, and more preferably dextran sulfate. The present invention also provides chemically defined, protein-free eukaryotic cell culture media comprising an iron chelate and zinc, which is capable of supporting the growth (and particularly the high-density growth of mammalian cells) in suspension culture, increasing the level of expression of recombinant protein in cultured cells, and/or increasing virus production in cultured cells.
    Type: Grant
    Filed: June 14, 2005
    Date of Patent: June 12, 2012
    Assignee: Life Technologies Corporation
    Inventors: Stephen F. Gorfien, Richard M. Fike, Glenn P. Godwin, Joyce L. Dzimian, David A. Epstein, Dale Gruber, Don McClure, Paul J. Price
  • Publication number: 20090280533
    Abstract: The present invention provides a cell culture medium formulation that supports the in vitro cultivation, particularly in suspension, of mammalian cells, particularly epithelial cells and fibroblast cells, and methods for cultivating mammalian cells in suspension in vitro using these media. The media comprise a basal medium and a polyanionic or polyanionic compound, preferably a polysulfonated or polysulfated compound, and more preferably dextran sulfate. The present invention also provides chemically defined, protein-free eukaryotic cell culture media comprising an iron chelate and zinc, which is capable of supporting the growth (and particularly the high-density growth of mammalian cells) in suspension culture, increasing the level of expression of recombinant protein in cultured cells, and/or increasing virus production in cultured cells.
    Type: Application
    Filed: May 8, 2009
    Publication date: November 12, 2009
    Applicant: LIFE TECHNOLOGIES CORPORATION
    Inventors: Stephen F. Gorfien, Richard M. Fike, Glenn P. Godwin, Joyce L. Dzimian, David A. Epstein, Dale Gruber, Don McClure, Paul J. Price
  • Publication number: 20090280532
    Abstract: The present invention provides a cell culture medium formulation that supports the in vitro cultivation, particularly in suspension, of mammalian cells, particularly epithelial cells and fibroblast cells, and methods for cultivating mammalian cells in suspension in vitro using these media. The media comprise a basal medium and a polyanionic or polyanionic compound, preferably a polysulfonated or polysulfated compound, and more preferably dextran sulfate. The present invention also provides chemically defined, protein-free eukaryotic cell culture media comprising an iron chelate and zinc, which is capable of supporting the growth (and particularly the high-density growth of mammalian cells) in suspension culture, increasing the level of expression of recombinant protein in cultured cells, and/or increasing virus production in cultured cells.
    Type: Application
    Filed: May 8, 2009
    Publication date: November 12, 2009
    Applicant: LIFE TECHNOLOGIES CORPORATION
    Inventors: Stephen F. GORFIEN, Richard M. FIKE, Glenn P. GODWIN, Joyce L. DZIMIAN, David A. EPSTEIN, Dale GRUBER, Don McCLURE, Paul J. PRICE
  • Publication number: 20070190046
    Abstract: This present invention provides a composition that is suitable for administration to a human subject comprising an anti-A? antibody that is free of A? peptide or that has acceptably low levels thereof, free of non-human A? peptide or that has acceptably low levels thereof, or having an undetectable concentration of A? peptide.
    Type: Application
    Filed: February 17, 2005
    Publication date: August 16, 2007
    Inventors: Ronald DeMaattos, Uma Kuchibhotia, Hsiu-Chiung Yang, Don McClure
  • Publication number: 20060148074
    Abstract: The present invention provides a cell culture medium formulation that supports the in vitro cultivation, particularly in suspension, of mammalian cells, particularly epithelial cells and fibroblast cells, and methods for cultivating mammalian cells in suspension in vitro using these media. The media comprise a basal medium and a polyanionic or polyanionic compound, preferably a polysulfonated or polysulfated compound, and more preferably dextran sulfate. The present invention also provides chemically defined, protein-free eukaryotic cell culture media comprising an iron chelate and zinc, which is capable of supporting the growth (and particularly the high-density growth of mammalian cells) in suspension culture, increasing the level of expression of recombinant protein in cultured cells, and/or increasing virus production in cultured cells.
    Type: Application
    Filed: June 14, 2005
    Publication date: July 6, 2006
    Inventors: Stephen Gorfien, Richard Fike, Glenn Godwin, Joyce Dzimian, David Epstein, Dale Gruber, Don McClure, Paul Price