Abstract: A vent manipulation system includes a building that has a ceiling and a floor. The ceiling is spaced from the floor and the ceiling is inaccessible without a ladder. A vent is coupled to the ceiling and the vent may pass air through the ceiling. A tool is provided and the tool may be manipulated. The tool engages the vent such that the tool adjusts the vent between an open position and a closed position. Thus, the tool adjusts the vent without the ladder.

Abstract: A vent manipulation system includes a building that has a ceiling and a floor. The ceiling is spaced from the floor and the ceiling is inaccessible without a ladder. A vent is coupled to the ceiling and the vent may pass air through the ceiling. A tool is provided and the tool may be manipulated. The tool engages the vent such that the tool adjusts the vent between an open position and a closed position. Thus, the tool adjusts the vent without the ladder.

Abstract: The present invention relates generally to compounds which modulate cytokine-dependent processes. More particularly, the compounds of the present invention modulate responses to a colony stimulating factor and even more particularly to granulocyte-colony stimulating factor (G-CSF) by modulating the levels of molecules which inhibit G-CSF such as but not limited to a suppressor of cytokine signaling (SOCS) and in particular SOCS-3. The present invention further contemplates methods for regulating G-CSF-dependent processes by contacting cells in vitro with or administering to a subject a compound which up- or down-regulates the level of activity of G-CSF by modulating the level or activity of a SOCS molecule such as SOCS-3. The instant compounds are further useful for modulating a range of G-CSF-induced cellular responses including neutrophil recovery after chemotherapy or radiotherapy, mobilizing stem and progenitor cells, treating infection and treating inflammatory conditions.