Patents by Inventor Don N. Gray
Don N. Gray has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 5763586Abstract: The extraction of proteins from selected naturally occurring membranes without any harmful, adverse, or other deleterious effect(s). In one preferred embodiment the detergent is prepared from the reaction of a cycloalkyl aliphatic alcohol and a saccharide.Type: GrantFiled: November 12, 1996Date of Patent: June 9, 1998Assignee: Anatrace, Inc.Inventor: Don N. Gray
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Patent number: 5674987Abstract: The extraction of proteins from selected naturally occurring membranes without any harmful, adverse, or other deleterious effect(s). In one preferred embodiment the detergent is prepared from the reaction of a cycloalkyl aliphatic alcohol and a saccharide.Type: GrantFiled: July 22, 1994Date of Patent: October 7, 1997Assignee: Anatrace, Inc.Inventor: Don N. Gray
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Patent number: 5391580Abstract: A biocompatable multi-layer article suitable for use in blood oxygenation is disclosed. The article is made up of a microporous polypropylene tube, a perm-selective, water vapor impermeable, carbon dioxide and oxygen permeable, homogeneous layer directly adhered to the polypropylene tube and active heparin linked through a covalent bond to the permselective layer. The polypropylene tube has an inside diameter from 240 to 400 .mu.m, a wall thickness from 10 to 50 .mu.m, and a porosity from 20 to 80 percent. The perm-selective layer is a polysulfone which has the structure ##STR1## where R is an alkyl group having 16 carbon atoms and n is 3,500 to 35,000. A method for producing a biocompatible multi-layer article suitable for use in blood oxygenation is also disclosed. The method involves the steps of immersing a microporous polypropylene tube which has an inside diameter from 240 to 400 .mu.m, a wall thickness from 10 to 50 .mu.Type: GrantFiled: May 10, 1993Date of Patent: February 21, 1995Assignee: Anatrace Inc.Inventors: Mary B. Douglas, Don N. Gray, Barry Watson, Christopher S. Youngen
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Patent number: 4423930Abstract: A series of alpha-olefin sulfur dioxide copolymers derived from the C.sub.4 to C.sub.18 alpha-olefins which may be readily processed to an optical article, such as a contact lens, having oxygen and carbon dioxide permeability which make them desirable in uses for contact lenses.Type: GrantFiled: March 23, 1981Date of Patent: January 3, 1984Assignee: Owens-Illinois, Inc.Inventor: Don N. Gray
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Patent number: 4277560Abstract: This invention relates to a method and apparatus for the rapid quantitative determination of an antigen contained in aqueous biochemical samples, for example, blood. The method comprises a series of sequentially arranged stages through which a buffered stream flows. The sample, containing an unknown concentration of the antigen, is injected into the buffered flowing stream and contacts various reagents in the sequential series of stages. An initial solubilization stage comprises an immobilized antibody on a substrate which antibody is specific to the antigen in the sample. The immobilized antibody has been reacted previously to saturation with an enzyme-antigen complex, the antigen of the complex being the same as the antigen in the sample, and the complex is reversably bound to the immobilized antibody.Type: GrantFiled: October 24, 1978Date of Patent: July 7, 1981Assignee: Technicon Instruments CorporationInventors: Don N. Gray, Melvin H. Keyes
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Patent number: 4179757Abstract: There is disclosed the preparation of an alpha-olefin-sulfur dioxide copolymer derived from the C.sub.8 to C.sub.18 alpha-olefins. The polymers undergo clean thermal degradation, having high permeabilities to oxygen and carbon dioxide, and are readily processed into a membrane article. Maximum permeabilities are obtained with the C.sub.16 based polymer. New uses of the copolymer are set forth including perfusion membranes, soft contact lenses and biocompatible articles for contact with human body fluids including surgical tubing, wound dressings, and prosthetic devices such as artificial veins, arteries and heart valves.Type: GrantFiled: May 10, 1976Date of Patent: December 25, 1979Assignee: Owens-Illinois, Inc.Inventors: James E. Crawford, Don N. Gray
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Patent number: 4052286Abstract: A noble metal-glass composite is screen printed on an inert substrate such as a low alkali glass and fired to provide a solid sensor electrode.Type: GrantFiled: January 31, 1973Date of Patent: October 4, 1977Assignee: Owens-Illinois, Inc.Inventors: Don N. Gray, George G. Guilbault
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Patent number: 3985715Abstract: The application discloses polymers and methods of making same in which a chlorine atom of a chloromethyl pendant group of a polymer such as a chloromethylated copolymer of styrene and divinylbenzene is substituted with a derivative of malonic acid having a protected amino group on the alpha-carbon atom and two carboxyl groups or precursors thereof to form, via several steps, the alpha-amino acid derivative of the starting polymer. These polymers are used, for instance, as ion exchange resins, as substrates for affinity chromotography, and as a starting resin for solid peptide synthesis. The resultant polymer is also used as a starting material to make a polymer with a pendant group that is a derivative of oxazolidone-2,5-dione, substituted at the 4-position. These polymers are used, for example, as the matrix for solid phase peptide synthesis and as the starting resin for solid phase peptide degradation.Type: GrantFiled: October 15, 1974Date of Patent: October 12, 1976Assignee: Owens-Illinois, Inc.Inventor: Don N. Gray
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Patent number: 3970603Abstract: The application discloses polymers and methods of making same in which a chlorine atom of a chloromethyl pendant group of a polymer such as a chloromethylated copolymer of styrene and divinylbenzene is substituted with a derivative of malonic acid having a protected amino group on the alpha-carbon atom and two carboxyl groups or precursors thereof to form, via several steps, the alpha-amino acid derivative of the starting polymer. These polymers are used, for instance, as ion exchange resins, as substrates for affinity chromotography, and as a starting resin for solid peptide synthesis. The resultant polymer is also used as a starting material to make a polymer with a pendant group that is a derivative of oxazolidone-2,5-dione, substituted at the 4-position. These polymers are used, for example, as the matrix for solid phase peptide synthesis and as the starting resin for solid phase peptide degradation.Type: GrantFiled: October 15, 1974Date of Patent: July 20, 1976Assignee: Owens-Illinois, Inc.Inventor: Don N. Gray
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Patent number: 3969284Abstract: The application discloses polymers and methods of making same in which a chlorine atom of a chloromethyl pendant group of a polymer such as a chloromethylated copolymer of styrene and divinylbenzene is substituted with a derivative of malonic acid having a protected amino group on the alpha-carbon atom and two carboxyl groups or precursors thereof to form, via several steps, the alpha-amino acid derivative of the starting polymer. These polymers are used, for instance, as ion exchange resins, as substrates for affinity chromotography, and as a starting resin for solid peptide synthesis. The resultant polymer is also used as a starting material to make a polymer with a pendant group that is a derivative of oxazolidone-2,5-dione, substituted at the 4-position. These polymers are used, for example, as the matrix for solid phase peptide synthesis and as the starting resin for solid phase peptide degradation.Type: GrantFiled: May 24, 1973Date of Patent: July 13, 1976Assignee: Owens-Illinois, Inc.Inventor: Don N. Gray
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Patent number: 3957497Abstract: There is disclosed the preparation of a polymeric based composition comprising a finely divided, particulate inorganic material dispersed in a low molecular weight, low vapor pressure, liquid having a relatively constant viscosity and thixotropic character and capable of being decomposed or pyrolyzed completely to gaseous products at a relatively low temperature without forming a carbonaceous or like residue having a deleterious effect(s) in the application of the composition to a substrate.Type: GrantFiled: December 4, 1970Date of Patent: May 18, 1976Assignee: Owens-Illinois, Inc.Inventors: Don N. Gray, John D. Grier