Patents by Inventor Don P. R. L. Giudicelli

Don P. R. L. Giudicelli has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 4311708
    Abstract: The invention provides phenol ethers of the formula: ##STR1## whereinR is branched C.sub.3-4 alkyl, C.sub.3-4 cycloalkyl, branched cyano(C.sub.3-4 alkyl), phenyl(C.sub.2-3 alkyl), halophenyl(C.sub.2-3 alkyl), (C.sub.1-4 alkoxy)phenyl(C.sub.2-4 alkyl), or (C.sub.1-4 acyl)amino(C.sub.1-4 alkyl),alk is C.sub.1-4 alkyl substituted by a 3 to 6 membered cycloalkyl group,X is --O--, --S-- or --SO.sub.2 --; andR.sub.1 is --C.sub.1-4 alkyl- or --C.sub.1-4 alkoxy-,in their racemic and optically active forms, and their addition salts with pharmaceutically acceptable acids. These compounds are useful in therapy as .beta.-adrenergic blocking agents. Intermediates are also provided.
    Type: Grant
    Filed: March 14, 1979
    Date of Patent: January 19, 1982
    Assignee: Synthelabo
    Inventors: Philippe M. J. Manoury, Icilio A. G. Cavero, Henry Najer, Don P. R. L. Giudicelli
  • Patent number: 4189495
    Abstract: The invention provides novel 2-methoxy-benzamide derivatives of the formula: ##STR1## in which n is 1 or 2; R.sub.1 represents a cycloalkyl-alkyl radical of formula: ##STR2## a phenylalkyl radical of formula ##STR3## (in which m is an integer from 2 to 5, A is a linear or branched alkylene chain of 1 to 4 carbon atoms, and R.sub.4 is hydrogen, halogen, especially fluorine or chlorine, trifluoromethyl, or alkyl or alkoxy of 1 to 3 carbon atoms), CNCH.sub.2 --CH.sub.2 --, CH.tbd.C--CH.sub.2 --, ##STR4## R.sub.2 is either chlorine, SO.sub.2 R.sub.5 (in which R.sub.5 is alkyl of 1 to 4 carbon atoms), or SO.sub.2 NR.sub.6 R.sub.7 (in which, R.sub.6 and R.sub.7, which are identical or different, represent, independently of one another, hydrogen or alkyl of 1 to 4 carbon atoms); and R.sub.3 is hydrogen or alkyl of 1 to 4 carbon atoms; in the form of racemates or optical isomers, and their pharmaceutically acceptable acid addition salts, which are useful in the treatment of psychosomatic and pyschotic disturbances.
    Type: Grant
    Filed: October 4, 1978
    Date of Patent: February 19, 1980
    Assignee: Synthelabo
    Inventors: Jean-Pierre Kaplan, Bernard M. Raizon, Daniel C. L. Obitz, Philippe M. J. Manoury, Henry Najer, Maurice Jalfre, Don P. R. L. Giudicelli
  • Patent number: 4172143
    Abstract: The invention provides novel 2-methoxy-benzamide derivatives of the formula: ##STR1## WHEREIN,M IS AN INTEGER FROM 2 TO 5;A is a linear or branched alkylene chain of 1 to 4 carbon atoms;R.sub.2 is chlorine, SO.sub.2 R.sub.5 or SO.sub.2 NR.sub.6 R.sub.7 ;R.sub.3 is hydrogen or alkyl of 1 to 4 carbon atoms;R.sub.5 is alkyl of 1 to 4 carbon atoms;EACH OF R.sub.6 and R.sub.7 is independently hydrogen or alkyl of 1 to 4 carbon atoms in the form of racemates or optical isomers and their pharmaceutically acceptable acid addition salts which are useful in the treatment of psychosomatic and psychotic disturbances.
    Type: Grant
    Filed: June 16, 1977
    Date of Patent: October 23, 1979
    Assignee: Synthelabo
    Inventors: Jean-Pierre Kaplan, Bernard M. Raizon, Daniel C. L. Obitz, Philippe M. J. Manoury, Henry Najer, Maurice Jalfre, Don P. R. L. Giudicelli
  • Patent number: 4158060
    Abstract: The invention provides novel 2-methoxy-benzamide derivatives of the formula: ##STR1## in which n is 1 or 2; R.sub.1 represents a cycloalkyl-alkyl radical of formula: ##STR2## a phenylalkyl radical of formula ##STR3## (in which m is an integer from 2 to 5, A is a linear or branched alkylene chain of 1 to 4 carbon atoms, and R.sub.4 is hydrogen, halogen, especially fluorine or chlorine, trifluoromethyl, or alkyl or alkoxy of 1 to 3 carbon atoms), CNCH.sub.2 --CH.sub.2 --, CH.tbd.C--CH.sub.2 --, ##STR4## R.sub.2 is either chlorine, SO.sub.2 R.sub.5 (in which R.sub.5 is alkyl of 1 to 4 carbon atoms), or SO.sub.2 NR.sub.6 R.sub.7 (in which, R.sub.6 and R.sub.7, which are identical or different, represent, independently of one another, hydrogen or alkyl of 1 to 4 carbon atoms); and R.sub.3 is hydrogen or alkyl of 1 to 4 carbon atoms; in the form of racemates or optical isomers, and their pharmaceutically acceptable acid addition salts, which are useful in the treatment of psychosomatic and psychotic disturbances.
    Type: Grant
    Filed: December 10, 1976
    Date of Patent: June 12, 1979
    Assignee: Synthelabo
    Inventors: Jean-Pierre Kaplan, Bernard M. Raizon, Daniel C. L. Obitz, Philippe M. J. Manoury, Henry Najer, Maurice Jalfre, Don P. R. L. Giudicelli
  • Patent number: 4148923
    Abstract: Trifluoromethylthiophenylethylamine derivatives, made from the corresponding acid chlorides by successive reduction, condensation with nitroethane, reduction, and condensation with an amine, possess anorexigenic properties, unaccompanied by central stimulant activity or cardiovascular effects.
    Type: Grant
    Filed: January 16, 1978
    Date of Patent: April 10, 1979
    Assignee: Synthelabo
    Inventors: Don P. R. L. Giudicelli, Henry Najer
  • Patent number: 4129598
    Abstract: Trifluoromethylthiophenylethylamine derivatives, made from the corresponding acid chlorides by successive reduction, condensation with nitroethane, reduction, and condensation with an amine, possess anorexigenic properties, unaccompanied by central stimulant activity or cardiovascular effects.
    Type: Grant
    Filed: May 24, 1974
    Date of Patent: December 12, 1978
    Assignee: Synthelabo
    Inventors: Don P. R. L. Giudicelli, Henry Najer