Patents by Inventor Don Smyth

Don Smyth has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Pharmaceutical compounds
    Patent number: 11377443
    Abstract: A compound which is an arylimidazolyl isoxazole of formula (I): (Formula (I)) or a pharmaceutically acceptable salt thereof. The compound has activity in modulating the activity of p300 and/or CBP and is used to treat cancer, particularly prostate cancer.
    Type: Grant
    Filed: May 14, 2020
    Date of Patent: July 5, 2022
    Assignee: CELLCENTRIC LIMITED
    Inventors: Neil Anthony Pegg, Stuart Thomas Onions, David Michel Adrien Taddei, Jonathan Shannon, Silvia Paoletta, Richard James Brown, Don Smyth, Gareth Harbottle
  • Tetrahydro-benzo[d]azepine derivatives as GPR120 modulators
    Patent number: 11220483
    Abstract: Novel tetrahydroisoquinoline and tetrahydrobenzazepine compounds of formula (I) capable of modulating the G-protein-coupled receptor GPR120, compositions comprising the compounds, and methods for their use for controlling insulin levels in vivo and for the treatment of conditions such as of diabetes, inflammation, obesity and metabolic diseases.
    Type: Grant
    Filed: March 26, 2018
    Date of Patent: January 11, 2022
    Assignee: CALDAN THERAPEUTICS LTD
    Inventors: Jane Brown, Stephen Connolly, Steffen V. F. Hansen, Gavin Milne, Bharat Shimpukade, Don Smyth, Gerard Thomas, Trond Ulven, Matjaz Brvar, Aaron Rigby
  • PHARMACEUTICAL COMPOUNDS
    Publication number: 20200407349
    Abstract: A compound which is an arylimidazolyl isoxazole of formula (I): (Formula (I)) or a pharmaceutically acceptable salt thereof. The compound has activity in modulating the activity of p300 and/or CBP and is used to treat cancer, particularly prostate cancer.
    Type: Application
    Filed: May 14, 2020
    Publication date: December 31, 2020
    Inventors: Neil Anthony PEGG, Stuart Thomas ONIONS, David Michel Adrien TADDEI, Jonathan SHANNON, Silvia PAOLETTA, Richard James BROWN, Don SMYTH, Gareth HARBOTTLE
  • TETRAHYDRO-BENZO[D]AZEPINE DERIVATIVES AS GPR120 MODULATORS
    Publication number: 20200317619
    Abstract: Novel tetrahydroisoquinoline and tetrahydrobenzazepine compounds of formula (I) capable of modulating the G-protein-coupled receptor GPR120, compositions comprising the compounds, and methods for their use for controlling insulin levels in vivo and for the treatment of conditions such as of diabetes, inflammation, obesity and metabolic diseases.
    Type: Application
    Filed: March 26, 2018
    Publication date: October 8, 2020
    Inventors: Jane BROWN, Stephen CONNOLLY, Steffen V.F. HANSEN, Gavin MILNE, Bharat SHIMPUKADE, Don SMYTH, Gerard THOMAS, Trond ULVEN, Matjaz BRVAR, Aaron RIGBY
  • ACTIVE IDENTIFICATION AND DIMENSIONING
    Publication number: 20200233901
    Abstract: Object identification and dimensioning system, device, and method embodiments generate a plurality of object records associated with corresponding physical objects. An image input sub-system provides N sets of image data, wherein N is an integer that begins at one and increases incrementally. An output record sub-system provides an object record to a determined function. The object record has object identification information and object dimension information associated with a certain physical object. And a processor-based sub-system begins with a first of N set of image data and incrementally processes each of N sets of image data until a record corresponding to the certain physical object is located in a repository or until N has reached a determined maximum number of image data sets.
    Type: Application
    Filed: January 18, 2019
    Publication date: July 23, 2020
    Inventors: Brian Crowley, Don Smyth, David Justin Ross
  • Pharmaceutical compounds
    Patent number: 10696666
    Abstract: A compound which is an arylimidazolyl isoxazole of formula (I): (Formula (I)) or a pharmaceutically acceptable salt thereof. The compound has activity in modulating the activity of p300 and/or CBP and is used to treat cancer, particularly prostate cancer.
    Type: Grant
    Filed: October 18, 2017
    Date of Patent: June 30, 2020
    Assignee: CELLCENTRIC LIMITED
    Inventors: Neil Anthony Pegg, Stuart Thomas Onions, David Michel Adrien Taddei, Jonathan Shannon, Silvia Paoletta, Richard James Brown, Don Smyth, Gareth Harbottle
  • PHARMACEUTICAL COMPOUNDS
    Publication number: 20190375740
    Abstract: A compound which is an arylimidazolyl isoxazole of formula (I): (Formula (I)) or a pharmaceutically acceptable salt thereof. The compound has activity in modulating the activity of p300 and/or CBP and is used to treat cancer, particularly prostate cancer.
    Type: Application
    Filed: October 18, 2017
    Publication date: December 12, 2019
    Inventors: Neil Anthony PEGG, Stuart Thomas ONIONS, David Michel Adrien TADDEI, Jonathan SHANNON, Silvia PAOLETTA, Richard James BROWN, Don SMYTH, Gareth HARBOTTLE
  • Substituted pyrrolo[2.3-B]pyridines
    Patent number: 7465726
    Abstract: Compounds represented by Formula (I): or stereoisomers or pharmaceutically acceptable salts thereof, are inhibitors of least two of the Abl, Aurora-A, Blk, c-Raf, cSRC, Src, PRK2, FGFR3, Flt3, Lck, Mek1, PDK-1, GSK3?, EGFR, p70S6K, BMX, SGK, CaMKII, Tie-2, IGF-1R, Ron, Ret, and KDR kinases in animals, including humans, for the treatment and/or prevention of various diseases and conditions such as cancer.
    Type: Grant
    Filed: August 1, 2005
    Date of Patent: December 16, 2008
    Assignee: OSI Pharmaceuticals, Inc.
    Inventors: Saleh Ahmed, Oscar Barba, Jason Bloxham, Graham Dawson, William Gattrell, John Kitchin, Neil Anthony Pegg, Imaad Saba, Shazia Sadiq, Colin Peter Sambrook Smith, Don Smyth, Amo G. Steinig, Robin Wilkes, Bijoy Panicker, Paula Tavares, Matthew Cox, An-Hu Li, Hanqing Dong, Lifu Ma, Kenneth (‘Ken’) Foreman, Qinghua (‘Felix’) Weng, Kathryn Stolz
  • Aryl-amino substituted pyrrolopyrimidine multi-kinase inhibiting compounds
    Publication number: 20060211678
    Abstract: Compounds represented by Formula (I): or stereoisomers or pharmaceutically acceptable salts thereof, are inhibitors of least two of the Abl, Aurora-A, Blk, c-Raf, cSRC, Src, PRK2, FGFR3, Flt3, Lck, Mek1, PDK-1, GSK3?, EGFR, p70S6K, BMX, SGK, CaMKII, Tie-2, IGF-1R, Ron, Ret, and KDR kinases in animals, including humans, for the treatment and/or prevention of various diseases and conditions such as cancer.
    Type: Application
    Filed: August 1, 2005
    Publication date: September 21, 2006
    Inventors: Saleh Ahmed, Oscar Barba, Jason Bloxham, Graham Dawson, Wiliam Gattrell, John Kitchin, Neil Anthony Pegg, Imaad Saba, Shazia Sadiq, Colin Peter Sambrook Smith, Don Smyth, Amo Steing, Robin Wilkes, Bijoy Panicker, Paula Tavares, Matthew Cox, An-Hu Li, Hanqing Dong, Lifu Ma, Kenneth Foreman, Qinghua Weng, Kathryn Stolz
  • (2-carboxamido)(3-amino)thiophene compounds
    Patent number: 6949563
    Abstract: Compounds represented by Formula (I): or a pharmaceutically acceptable salt or N-oxide thereof, wherein R1 is R2 is and R3 is C0-4alkyl, are useful in the treatment of cancer.
    Type: Grant
    Filed: January 6, 2004
    Date of Patent: September 27, 2005
    Inventors: Graham Michael Wynne, Kevin Doyle, Saleh Ahmed, An-Hu Li, John Fraser Keily, Chrystelle Marie Rasamison, Neil Anthony Pegg, Imaad Saba, Claire Thomas, Don Smyth, Shazia Sadiq, Gary Newton, Graham Dawson, Andrew Phillip Crew, Arlindo Lucas Castelhano
  • (2-carboxamido)(3-amino)thiophene compounds
    Publication number: 20040186124
    Abstract: Compounds represented by Formula (I): 1
    Type: Application
    Filed: January 6, 2004
    Publication date: September 23, 2004
    Inventors: Graham Michael Wynne, Kevin Doyle, Saleh Ahmed, An-Hu Li, John Fraser Keily, Chrystelle Marie Rasamison, Neil Anthony Pegg, Imaad Saba, Claire Thomas, Don Smyth, Shazia Sadiq, Gary Newton, Graham Dawson, Andrew Phillip Crew, Arlindo Lucas Castelhano